1994 …2020

Research output per year

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Research Output

Article
47 Citations (Scopus)

Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds

Chanput, W., Mes, J. J., Savelkoul, H. F. J. & Wichers, H. J., 2013, In : Food & Function. 4, 2, p. 266-276

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Characterization of the total free radical scavenger capacity of vegetable oils and oil fractions using 2,2-diphellyl-1-picrylhydrazyl radical

Espin, J. C., Soler Rivas, C. & Wichers, H. J., 2000, In : Journal of Agricultural and Food Chemistry. 43, 3, p. 648-656

Research output: Contribution to journalArticleAcademicpeer-review

Cloning, expression and characterisation of two tyrosinase cDNAs from Agaricus bisporus

Wichers, H. J., Recourt, K., Hindriks, M., Ebbelaar, C. E. M., Biancone, G., Hoeberichts, F. A. & Mooibroek, A., 2003, In : Applied Microbiology and Biotechnology. 61, 4, p. 336-341

Research output: Contribution to journalArticleAcademicpeer-review

86 Citations (Scopus)

Combined instrumental and sensory evaluation of flavor of fresh bell peppers (Capsicum annuum) harvested at three maturation stages.

Luning, P. A., van der Vuurst de Vries, R., Yuksel, D., Ebbenhorst-Seller, T., Wichers, H. J. & Roozen, J. P., 1994, In : Journal of Agricultural and Food Chemistry. 42, p. 2855-2861

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Consumption of β-glucans to spice up T cell treatment of tumors: a review

de Graaff, P., Govers, C., Wichers, H. J. & Debets, R., 3 Oct 2018, In : Expert Opinion on Biological Therapy. 18, 10, p. 1023-1040

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Cross-reactivity between peanut and lupin proteins

Sirtori, E., Resta, D., Arnoldi, A., Savelkoul, H. F. J. & Wichers, H. J., 2011, In : Food Chemistry. 126, 3, p. 902-910

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Crystallization and preliminary X-ray crystallographic analysis of tyrosinase from the mushroom Agaricus bisporus

Ismaya, W. T., Rozeboom, H. J., Schurink, M., Boeriu, C. G., Wichers, H. J. & Dijkstra, B. W., 2011, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 67, 5, p. 575-578

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone

Ismaya, W. T., Rozeboom, H. J., Weijn, A., Mes, J. J., Fusetti, F., Wichers, H. J. & Dijkstra, B. W., 2011, In : Biochemistry. 50, 24, p. 5477-5486

Research output: Contribution to journalArticleAcademicpeer-review

408 Citations (Scopus)

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution

Lai, X., Soler-Lopez, M., Ismaya, W. T., Wichers, H. J. & Dijkstra, B. W., 2016, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 72, 3, p. 244-250

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Curdlan, zymosan and a yeast-derived β-glucan reshape tumor-associated macrophages into producers of inflammatory chemo-attractants

de Graaff, P., Berrevoets, C., Rӧsch, C., Schols, H. A., Verhoef, K., Wichers, H. J., Debets, R. & Govers, C., 29 Aug 2020, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins

Liu, Y., Bastiaan-Net, S. & Wichers, H. J., 18 Aug 2020, In : Frontiers in Nutrition. 7, 132.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Decrease of the IgE-binding by Mal d 1, the major apple allergen, by means of polyphenol oxidase and peroxidase treatments

Garcia-Borrego, A., Wichers, J. H. & Wichers, H. J., 2007, In : Food Chemistry. 103, 1, p. 94-100

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J. & Masereeuw, R., Oct 2019, In : Toxicology in Vitro. 60, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Dietary Protein: Key to Feeding th 10 Billion

Wichers, H. J., Sep 2017, In : World of Food Ingredients. september, p. 70-72

Research output: Contribution to journalArticleProfessional

Open Access
4 Citations (Scopus)

Differential effects of Lactobacillus acidophilus and Lactobacillus plantarum strains on cytokine induction in human peripheral blood mononuclear cells

Vissers, Y. M., Snel, J., Zuurendonk, P. F., Smit, B. A., Wichers, H. J. & Savelkoul, H. F. J., 2010, In : FEMS Immunology and Medical Microbiology. 59, 1, p. 60-70

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Discoloration and tyrosinase activity in Agaricus bisporus fruit bodies infected with various pathogens

Soler-Rivas, C., Arpin, N., Olivier, J. M. & Wichers, H. J., 2000, In : Mycological Research. 104, 3, p. 351-356

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Distribution of ?-glutamyltransferase activity in Agaricus bisporus in mycelia and during fruitbody development

Jolivet, S., Mooibroek, A. & Wichers, H. J., 1998, In : FEMS Microbiology Letters. 163, p. 263-267

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Effect of captopril on mushroom tyrosinase activity in vitro

Espin, J. C. & Wichers, H. J., 2001, In : Biochimica et biophysica acta-protein structure and molecular enzymology. 1544, 1-2, p. 289-300

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Scopus)

Effect of Heating and Glycation on the Allergenicity of 2S Albumins (Ara h 2/6) from Peanut

Vissers, Y. M., Blanc, F., Stahl Skov, P., Johnson, P. E., Rigby, N. M., Przybylski-Nicaise, L., Bernhard, H., Wal, J. M., Ballmer-Weber, B., Zuidmeer-Jongejan, L., Szepfalusi, Z., Ruinemans-Koerts, J., Jansen, A. P. H., Savelkoul, H. F. J., Wichers, H. J., Mackie, A. R., Mills, E. N. C. & Adel-Patient, K., 2011, In : PLoS ONE. 6, 8, 9 p., e23998.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
74 Citations (Scopus)

Effect of heat treatment on the potential allergenicity and conformational structure of egg allergen ovotransferrin

Tong, P., Chen, H., Gao, J., Li, X., Jian, S., Wichers, H. J., Wu, Z. & Yang, A., 2012, In : Food Chemistry. 131, p. 603-610 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

61 Citations (Scopus)

Effect of Maillard reaction on biochemical properties of peanut 7S globulin (Ara h 1) and its interaction with a human colon cancer cell line (Caco-2)

Teodorowicz, M., Fiedorowicz, E., Kostyra, H., Wichers, H. J. & Kostyra, E., 2013, In : European Journal of Nutrition. 52, 8, p. 1927-1938

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Effect of olive mill waste (OMW) supplementation to Oyster mushrooms substrates on the cultivation parameters and fruiting bodies quality

Ruiz-Rodriguez, A., Soler-Rivas, C., Polonia, I. & Wichers, H. J., 2010, In : International Biodeterioration and Biodegradation. 64, 7, p. 638-645

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6: the necessity of degranulation assays

Vissers, Y. M., Iwan, M., Adel-Patient, K., Stahl Skov, P., Rigby, N. M., Johnson, P. E., Mandrup Muller, P., Przybylski-Nicaise, L., Schaap, M., Ruinemans-Koerts, J., Jansen, A. P. H., Mills, E. N. C., Savelkoul, H. F. J. & Wichers, H. J., 2011, In : Clinical and Experimental Allergy. 41, 11, p. 1631-1642

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Enzymology and molecular biology of Agaricus bisporus tyrosinase

Wichers, H. J., van den Bosch, T., Gerritsen, Y. A. M., Oyevaar, J. I., Ebbelaar, C. E. M., Recourt, K. & Kerrigan, R. W., 1995, In : Mushroom Science. 14, p. 723-728

Research output: Contribution to journalArticleAcademicpeer-review

Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

Boers, I., Muskiet, F. A. J., Berkelaar, E., Schut, E., Penders, R., Hoenderdos, K., de Jong, M. C. & Wichers, H. J., 2014, In : Lipids in Health and Disease. 13, 13 p., 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
38 Citations (Scopus)

Food allergens of plant origin : their molecular and evolutionary relationships

Mills, E. N. C., Madsen, C., Shewry, P. R. & Wichers, H. J., 2003, In : Trends in Food Science and Technology. 14, 4, p. 145-156

Research output: Contribution to journalArticleAcademicpeer-review

85 Citations (Scopus)

Food Processing and Allergenicity

Verhoeckx, K., Vissers, Y., Baumert, J. L., Faludi, R., Fleys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., van der Bolt, N., Wichers, H. J. & Kimber, I., Apr 2015, In : Food and Chemical Toxicology. 80, p. 223-240

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
195 Citations (Scopus)
101 Citations (Scopus)

Geïntegreerde benadering van allergieproblematiek noodzakelijk

Wichers, H. J., 2004, In : Voedingsmiddelentechnologie. 37, 7, p. 28-29

Research output: Contribution to journalArticleProfessional

11 Citations (Scopus)

Groente blijkt ook in de schappen nog een dag-en-nachtritme te hebben. Spinazie bij groenteboer leeft nog

Keulemans, M. & Wichers, H. J., 2013, In : De Volkskrant. p. 5-5 1 p.

Research output: Contribution to journalArticlePopular

Heat treatment of β-lactoglobulin affects its digestion and translocation in the upper digestive tract

Deng, Y., Govers, C., Tomassen, M., Hettinga, K. & Wichers, H. J., 15 Nov 2020, In : Food Chemistry. 330, 127184.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Het allergeen centraal!

Wichers, H. J., 2006, In : Reactie : informatie en voorlichting over alle mogelijke vormen van allergie. 2, 2

Research output: Contribution to journalArticlePopular

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access

High molecular weight glucan of the culinary medicinal mushroom Agaricus bisporus is an a-glucan that forms complexes with low molecular weight galactan

Smiderle, F., Sassaki, G. L., van Arkel, J., Lacomini, M., Wichers, H. J. & van Griensven, L. J. L. D., 2010, In : Molecules. 15, 8, p. 5818-5830

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

House dust mite (Der p 10) and crustacean allergic patients may react to food containing Yellow mealworm proteins

Verhoeckx, K., van Broekhoven, S., den Hartog-Jager, C. F., Gaspari, M., de Jong, G. A. H., Wichers, H. J., van Hoffen, E., Houben, G. F. & Knulst, A. C., 2014, In : Food and Chemical Toxicology. 65, p. 364-373

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Hydrolysates of glycated and heat treated peanut 7S globulin (Ara h 1) modulate human gut microbiota proliferation, survival and adhesion

Teodorowicz, M., Swiatecka, D., Savelkoul, H. F. J., Wichers, H. J. & Kostyra, E., 2014, In : Journal of Applied Microbiology. 116, 2, p. 424-434

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Hydrophobicity and aggregation, but not glycation, are key determinants for uptake of thermally processed β-lactoglobulin by THP-1 macrophages

Deng, Y., Govers, C., Bastiaan-Net, S., van der Hulst, N., Hettinga, K. & Wichers, H. J., 1 Jun 2019, In : Food Research International. 120, p. 102-113 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

Deng, Y., Govers, C., Teodorowicz, M., Liobyte, I., de Simone, I., Hettinga, K. & Wichers, H. J., 14 Aug 2020, In : PLoS ONE. 15, 8 August, e0236212.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ice cream better tasting with antifreeze proteins. Properties and applications of antifreeze proteins

Wichers, H. J., Kreuwels, M. J. J. & Stolle-Smits, T., 1998, In : Voedingsmiddelentechnologie. 31, 22, p. 26-27, 50

Research output: Contribution to journalArticleProfessional

Identification and in silico bioinformatics analysis of PR10 proteins in cashew nut

Bastiaan-Net, S., Pina-Pérez, M. C., Dekkers, B. J. W., Westphal, A. H., America, A. H. P., Ariëns, R. M. C., de Jong, N. W., Wichers, H. J. & Mes, J. J., Jul 2020, In : Protein Science. 29, 7, p. 1581-1595

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of lipoxygenase inhibitory peptides from ß-casein by using SPOT synthesis

Schurink, M., van Berkel, W. J. H., Wichers, H. J. & Boeriu, C. G., 2006, In : ChemBioChem. 7, 5, p. 743-747

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method

Bastiaan-Net, S., Batstra, M. R., Aazamy, N., Savelkoul, H. F. J., Van Der Valk, J. P. M., Gerth Van Wijk, R., Schreurs, M. W. J., Wichers, H. J. & De Jong, N. W., 14 Feb 2020, In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Immunomodulation by food: promising concept for mitigating allergic disease?

Wichers, H. J., 2009, In : Analytical and Bioanalytical Chemistry. 395, 1, p. 37-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
48 Citations (Scopus)
Open Access
7 Citations (Scopus)