1994 …2020

Research output per year

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Research Output

2020

Beneficial health effects of chitin and chitosan

Dong, L., Wichers, H. J. & Govers, C. C. F. M., Jan 2020, Chitin and Chitosan: Properties and Applications. van den Broek, L. A. M., Boeriu, C. G. & Stevens, C. V. (eds.). John Wiley and Sons, p. 145-164 (Wiley Series in Renewable Research).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Beyond heat stress: Intestinal integrity disruption and mechanism-based intervention strategies

Lian, P., Braber, S., Garssen, J., Wichers, H. J., Folkerts, G., Fink-Gremmels, J. & Varasteh, S., 1 Mar 2020, In : Nutrients. 12, 3, 734.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
Open Access
1 Citation (Scopus)

Curdlan, zymosan and a yeast-derived β-glucan reshape tumor-associated macrophages into producers of inflammatory chemo-attractants

de Graaff, P., Berrevoets, C., Rӧsch, C., Schols, H. A., Verhoef, K., Wichers, H. J., Debets, R. & Govers, C., 29 Aug 2020, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins

Liu, Y., Bastiaan-Net, S. & Wichers, H. J., 18 Aug 2020, In : Frontiers in Nutrition. 7, 132.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Heat treatment of β-lactoglobulin affects its digestion and translocation in the upper digestive tract

Deng, Y., Govers, C., Tomassen, M., Hettinga, K. & Wichers, H. J., 15 Nov 2020, In : Food Chemistry. 330, 127184.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

Deng, Y., Govers, C., Teodorowicz, M., Liobyte, I., de Simone, I., Hettinga, K. & Wichers, H. J., 14 Aug 2020, In : PLoS ONE. 15, 8 August, e0236212.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification and in silico bioinformatics analysis of PR10 proteins in cashew nut

Bastiaan-Net, S., Pina-Pérez, M. C., Dekkers, B. J. W., Westphal, A. H., America, A. H. P., Ariëns, R. M. C., de Jong, N. W., Wichers, H. J. & Mes, J. J., Jul 2020, In : Protein Science. 29, 7, p. 1581-1595

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method

Bastiaan-Net, S., Batstra, M. R., Aazamy, N., Savelkoul, H. F. J., Van Der Valk, J. P. M., Gerth Van Wijk, R., Schreurs, M. W. J., Wichers, H. J. & De Jong, N. W., 14 Feb 2020, In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Phenylthiourea binding to human tyrosinase-related protein 1

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 1 Feb 2020, In : International Journal of Molecular Sciences. 21, 3, 915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Specific Polyunsaturated Fatty Acids Can Modulate in vitro Human moDC2s and Subsequent Th2 Cytokine Release

Hoppenbrouwers, T., Fogliano, V., Garssen, J., Pellegrini, N., Willemsen, L. E. M. & Wichers, H. J., 4 May 2020, In : Frontiers in Immunology. 11, 748.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of low vs. high temperature dry heating on solubility and digestibility of cow's milk protein

Zenker, H. E., Raupbach, J., Boeren, S., Wichers, H. J. & Hettinga, K. A., Dec 2020, In : Food Hydrocolloids. 109, 106098.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Wat zijn ze waard, die nieuwe eiwitten?

de Jong, G. A. H., Mes, J. J. & Wichers, H. J., Sep 2020, In : Voedingsindustrie : vakblad. 27, 6, p. 46-49

Research output: Contribution to journalArticleProfessional

Open Access

Wheat-derived arabinoxylans reduced M2-macrophage functional activity, but enhanced monocyte-recruitment capacity

Govers, C., Tang, Y., Stolte, E. H., Wichers, H. J. & Mes, J. J., 19 Aug 2020, In : Food & Function. 11, 8, p. 7073-7083

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Antihypertensive Activity Of Food Protein Hydrolysates From Sustainable Sources

van de Berg-Somhorst, B. P. M., Bastiaan-Net, S., Evers, D., El Bachrioui, K., Ariens, R. M. C. & Wichers, H. J., 2 Apr 2019.

Research output: Contribution to conferenceAbstract

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

Lozano-Ojalvo, D., Benedé, S., Antunes, C. M., Bavaro, S. L., Bouchaud, G., Costa, A., Denery-Papini, S., Díaz-Perales, A., Garrido-Arandia, M., Gavrovic-Jankulovic, M., Hayen, S., Martínez-Blanco, M., Molina, E., Monaci, L., Pieters, R. H. H., Villemin, C., Wichers, H. J., Wróblewska, B., Willemsen, L. E. M., Roggen, E. L. & 1 others, van Bilsen, J. H. M., 1 Mar 2019, In : Trends in Food Science and Technology. 85, p. 307-319

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J. & Masereeuw, R., Oct 2019, In : Toxicology in Vitro. 60, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Development of a trained immunity and resilience model for testing of orally applied β-glucans

Moerings, B., de Graaff, P., Wichers, H. J., Garssen, J., Witkamp, R. F., Debets, R., Mes, J. J., van Bergenhenegouwen, J. & Govers, C. C. F. M., 2019.

Research output: Contribution to conferencePosterAcademic

Open Access
4 Citations (Scopus)

Food-derived β-glucans polarize M2 macrophages towards an M1-like phenotype characterized by production of T cell chemo-attractants

de Graaff, P., Berrevoets, C., van Laar, A., Tomassen, M. M. M., Wichers, H. J., Debets, R. & Govers, C. C. F. M., Dec 2019.

Research output: Contribution to conferencePosterAcademic

Food-derived β-glucans polarize M2 macrophages towards an M1-like phenotype characterized by production of T cell chemo-attractants

de Graaff, P., Berrevoets, C., van Laar, A., Tomassen, M. M. M., Wichers, H. J., Debets, R. & Govers, C. C. F. M., Sep 2019.

Research output: Contribution to conferencePosterAcademic

Hydrophobicity and aggregation, but not glycation, are key determinants for uptake of thermally processed β-lactoglobulin by THP-1 macrophages

Deng, Y., Govers, C., Bastiaan-Net, S., van der Hulst, N., Hettinga, K. & Wichers, H. J., 1 Jun 2019, In : Food Research International. 120, p. 102-113 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity

Lacroix, I. M. E., Dávalos Terán, I., Fogliano, V. & Wichers, H. J., Mar 2019, In : International Journal of Food Science and Technology. 54, 3, p. 696-704 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Hoppenbrouwers, T., Cvejić Hogervorst, J. H., Garssen, J., Wichers, H. J. & Willemsen, L. E. M., 22 May 2019, In : Frontiers in Immunology. 10, 1118.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Pre-clinical protein screening in bioengineered intestinal tubules

Jochemsen, P., Garssen, J., Rietveld, P., Ariens, R. M. C., Bastiaan-Net, S., Wichers, H. J., van Bergenhenegouwen, J. & Masereeuw, R., 2019. 1 p.

Research output: Contribution to conferenceAbstract

Open Access

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)
2018

Consumption of β-glucans to spice up T cell treatment of tumors: a review

de Graaff, P., Govers, C., Wichers, H. J. & Debets, R., 3 Oct 2018, In : Expert Opinion on Biological Therapy. 18, 10, p. 1023-1040

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)
Open Access
7 Citations (Scopus)

Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses

Lépine, A. F. P., de Wit, N., Oosterink, E., Wichers, H., Mes, J. & de Vos, P., 2 Jul 2018, In : Frontiers in Microbiology. 9, 1439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
Open Access
Open Access

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

van der Valk, J. P. M., Berends, I., van Wijk, R. G., Arends, N. J. T., van Maaren, M. S., de Groot, H., Wichers, H. J., Emons, J. A. M., Dubois, A. E. J. & de Jong, N. W., Mar 2018, In : Annals of Allergy, Asthma and Immunology. 120, 3, p. 300-303

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2 Jan 2018, In : Chemistry - A European Journal. 24, 1, p. 47-55

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

The effect of exercise on intestinal integrity and protein permeability

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Bastiaan-Net, S., Mes, J. J., Luiking, Y., Wichers, H. J., Witkamp, R. F. & van Norren, K., 2018.

Research output: Contribution to conferenceAbstract

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2

Arena, M., Govers, C. C. F. M., Lotti, C., Ricciardi, L., Wichers, H. J. & Mes, J. J., 13 Mar 2018, In : Molecules. 23, 3, 644.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
2017

Adaptation of exercise-induced stress in well-trained healthy young men

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Lenaerts, K., Ridder, L. O., Nierkens, S., Kartaram, S., Verschuren, M. C. M., Pieters, R., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 2017, In : Experimental Physiology. 102, 1, p. 86-99

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Van Bilsen, J. H. M., Sienkiewicz-Szłapka, E., Lozano-Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., Ladics, G. S., Pieters, R. H. H., Denery-Papini, S., Vissers, Y. M., Bavaro, S. L., Larré, C., Verhoeckx, K. C. M. & Roggen, E. L., 2017, In : Clinical and Translational Allergy. 7, 1, 13.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7- proteinases hydrolyzed tilapia muscle proteins

Toopcham, T., Mes, J. J., Wichers, H. J., Roytrakul, S. & Jirawat, Y., 2017, In : Food Chemistry. 220, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Dietary Protein: Key to Feeding th 10 Billion

Wichers, H. J., Sep 2017, In : World of Food Ingredients. september, p. 70-72

Research output: Contribution to journalArticleProfessional