1994 …2020
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Research Output 1994 2019

2019

Antihypertensive Activity Of Food Protein Hydrolysates From Sustainable Sources

van de Berg-Somhorst, B. P. M., Bastiaan-Net, S., Evers, D., El Bachrioui, K., Ariens, R. M. C. & Wichers, H. J., 2 Apr 2019.

Research output: Contribution to conferencePosterAcademic

Antihypertensive Activity Of Food Protein Hydrolysates From Sustainable Sources

van de Berg-Somhorst, B. P. M., Bastiaan-Net, S., Evers, D., El Bachrioui, K., Ariens, R. M. C. & Wichers, H. J., 2 Apr 2019.

Research output: Contribution to conferenceAbstractAcademic

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

Lozano-Ojalvo, D., Benedé, S., Antunes, C. M., Bavaro, S. L., Bouchaud, G., Costa, A., Denery-Papini, S., Díaz-Perales, A., Garrido-Arandia, M., Gavrovic-Jankulovic, M., Hayen, S., Martínez-Blanco, M., Molina, E., Monaci, L., Pieters, R. H. H., Villemin, C., Wichers, H. J., Wróblewska, B., Willemsen, L. E. M., Roggen, E. L. & 1 othersvan Bilsen, J. H. M., 1 Mar 2019, In : Trends in Food Science and Technology. 85, p. 307-319

Research output: Contribution to journalReview articleAcademicpeer-review

protein sources
Food
food allergies
testing
assays
1 Citation (Scopus)

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J. & Masereeuw, R., Oct 2019, In : Toxicology in Vitro. 60, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Goblet Cells
Translational Medical Research
Caco-2 Cells
Nutrients
Extracellular Matrix
1 Citation (Scopus)
Open Access
lactoglobulins
immunoglobulin E
Lactoglobulins
Lactose
glycation

Effect Of Ultra-Filtration After In Vitro Digestion Of Sustainable Food Proteins On SCFA Production By Microbiota Fermentation

Ariens, R. M. C., El Bachrioui, K., van de Berg-Somhorst, B. P. M., Bastiaan-Net, S. & Wichers, H. J., 2 Apr 2019.

Research output: Contribution to conferencePosterProfessional

Effect Of Ultra-Filtration After In Vitro Digestion Of Sustainable Food Proteins On SCFA Production By Microbiota Fermentation

Ariens, R. M. C., El Bachrioui, K., van de Berg-Somhorst, B. P. M., Bastiaan-Net, S. & Wichers, H. J., 2 Apr 2019.

Research output: Contribution to conferenceAbstractAcademic

1 Citation (Scopus)
Open Access
lactoglobulins
Lactoglobulins
glycation
hydrophobicity
Hydrophobic and Hydrophilic Interactions
3 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Allergens
Immunoglobulin E
Anacardiaceae
1 Citation (Scopus)

Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity

Lacroix, I. M. E., Dávalos Terán, I., Fogliano, V. & Wichers, H. J., Mar 2019, In : International Journal of Food Science and Technology. 54, 3, p. 696-704 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Alphitobius diaperinus
Tenebrio
Dipeptidyl Peptidase 4
Peptides
peptides

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Hoppenbrouwers, T., Cvejić Hogervorst, J. H., Garssen, J., Wichers, H. J. & Willemsen, L. E. M., 22 May 2019, In : Frontiers in Immunology. 10, 1 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Food Hypersensitivity
Unsaturated Fatty Acids
Anti-Allergic Agents
Immune System Diseases
Quercetin
1 Citation (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Organic Anion Transporters
Proximal Kidney Tubule
Anions
Indican
Kidney
2018
2 Citations (Scopus)

Consumption of β-glucans to spice up T cell treatment of tumors: a review

de Graaff, P., Govers, C., Wichers, H. J. & Debets, R., 3 Oct 2018, In : Expert Opinion on Biological Therapy. 18, 10, p. 1023-1040

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Spices
T-cells
Glucans
Tumors
T-Lymphocytes
1 Citation (Scopus)
Open Access
Maillard Reaction
Advanced Glycosylation End Products
Immunomodulation
Livestock
Pets
5 Citations (Scopus)

Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses

Lépine, A. F. P., de Wit, N., Oosterink, E., Wichers, H., Mes, J. & de Vos, P., 2 Jul 2018, In : Frontiers in Microbiology. 9, 1439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactobacillus acidophilus
Tight Junctions
Salmonella typhimurium
Salmonella
Epithelial Cells
1 Citation (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Nuts
Anas
Open Access
Open Access
G-Protein-Coupled Receptors
Obesity
Islets of Langerhans
Type 2 Diabetes Mellitus
Food-Drug Interactions

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
allergens
saliva
Saliva
Allergens
peanuts
4 Citations (Scopus)

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

van der Valk, J. P. M., Berends, I., van Wijk, R. G., Arends, N. J. T., van Maaren, M. S., de Groot, H., Wichers, H. J., Emons, J. A. M., Dubois, A. E. J. & de Jong, N. W., Mar 2018, In : Annals of Allergy, Asthma and Immunology. 120, 3, p. 300-303

Research output: Contribution to journalArticleAcademicpeer-review

Anaphylaxis
Epinephrine
Food
Guidelines
Hypersensitivity
26 Citations (Scopus)

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2 Jan 2018, In : Chemistry - A European Journal. 24, 1, p. 47-55

Research output: Contribution to journalArticleAcademicpeer-review

Monophenol Monooxygenase
Proteins
Enzymes
Melanin
Mutagenesis

The effect of exercise on intestinal integrity and protein permeability

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Bastiaan-Net, S., Mes, J. J., Luiking, Y., Wichers, H. J., Witkamp, R. F. & van Norren, K., 2018.

Research output: Contribution to conferenceAbstractAcademic

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2

Arena, M., Govers, C. C. F. M., Lotti, C., Ricciardi, L., Wichers, H. J. & Mes, J. J., 13 Mar 2018, In : Molecules. 23, 3, 644.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Tomatine
gene expression
Gene expression
integrity
Monolayers
2017
3 Citations (Scopus)

Adaptation of exercise-induced stress in well-trained healthy young men

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Lenaerts, K., Ridder, L. O., Nierkens, S., Kartaram, S., Verschuren, M. C. M., Pieters, R., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 2017, In : Experimental Physiology. 102, 1, p. 86-99

Research output: Contribution to journalArticleAcademicpeer-review

Exercise
Lactulose
Rhamnose
Energy Metabolism
Urine
9 Citations (Scopus)

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Van Bilsen, J. H. M., Sienkiewicz-Szłapka, E., Lozano-Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., Ladics, G. S., Pieters, R. H. H., Denery-Papini, S., Vissers, Y. M., Bavaro, S. L., Larré, C., Verhoeckx, K. C. M. & Roggen, E. L., 2017, In : Clinical and Translational Allergy. 7, 1, 13.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Food
Proteins
Food Hypersensitivity
In Vitro Techniques
Cell Communication
20 Citations (Scopus)

Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7- proteinases hydrolyzed tilapia muscle proteins

Toopcham, T., Mes, J. J., Wichers, H. J., Roytrakul, S. & Jirawat, Y., 2017, In : Food Chemistry. 220, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

Virgibacillus
Myeloblastin
Tilapia
Muscle Proteins
peptidyl-dipeptidase A
7 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

Allergens
Immunoglobulins
Immunoglobulin G
Serum
Eating

Dietary Protein: Key to Feeding th 10 Billion

Wichers, H. J., Sep 2017, In : World of Food Ingredients. september, p. 70-72

Research output: Contribution to journalArticleProfessional

6 Citations (Scopus)

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactulose
allergens
peanuts
lactulose
exercise

Good, Bad, or Risky? intestinal permeability to protein: human and in vitro studies

JanssenDuijghuijsen, L. M., 2017, Wageningen: Wageningen University. 154 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Permeability
Exercise
Proteins
Lactulose
Rhamnose

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access
6 Citations (Scopus)

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase

Toopcham, T., Mes, J. J., Wichers, H. J. & Yongsawatdigul, J., 2017, In : Food Chemistry. 224, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

Virgibacillus
Myeloblastin
Protein Hydrolysates
pea protein
protein hydrolysates
8 Citations (Scopus)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

van der Valk, J. P. M., el Bouche, R., Gerth van Wijk, R., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Translational Allergy. 7, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Pistacia
Mangifera
Nuts
Hypersensitivity
2 Citations (Scopus)

Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype

Tang, Y., Govers, C., Wichers, H. J. & Mes, J. J., 2017, In : Journal of Functional Foods. 36, p. 280-289

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Polysaccharides
macrophages
polysaccharides
Macrophages
Phenotype
5 Citations (Scopus)

Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes claudin 7

Janssen Duijghuijsen, L. M., Grefte, S., de Boer, V. C. J., Zeper, L., van Dartel, D. A. M., van der Stelt, I., Bekkenkamp-Grovenstein, M., van Norren, K., Wichers, H. J. & Keijer, J., 11 Oct 2017, In : Frontiers in Physiology. 8, 13 p., 794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Adenosine Triphosphate
Caco-2 Cells
Claudin-2
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Galactose
Open Access
Polysaccharides
Macrophages
Epithelial Cells
Gene Expression
In Vitro Techniques
17 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
4 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Nuts
Immunoglobulin E
Nut Hypersensitivity
Food
29 Citations (Scopus)

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2017, In : Angewandte Chemie-International Edition. 56, 33, p. 9812-9815

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Monophenol Monooxygenase
Zinc
Proteins
Ions
Melanin

The aging immune system and nutritional interventions

Beek, A. A., 2017, Wageningen: Wageningen University. 250 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Immune System
Microbiota
Basophils
Spleen
Lactobacillus casei

The cashew allergens: a molecular and serological characterization

Reitsma, M., 2017, Wageningen: Wageningen University. 186 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
cashew nuts
allergens
Anas
proteins
hypersensitivity

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Language
5 Citations (Scopus)

Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity

Gil-Ramírez, A., Smiderle, F. R., Morales, D., Govers, C., Synytsya, A., Wichers, H. J., Iacomini, M. & Soler-Rivas, C., 2017, In : International Journal of Medicinal Mushrooms. 19, 10, p. 879-892

Research output: Contribution to journalArticleAcademicpeer-review

Pleurotus
Ostreidae
Agaricales
Glucans
Polysaccharides
2016
8 Citations (Scopus)

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution

Lai, X., Soler-Lopez, M., Ismaya, W. T., Wichers, H. J. & Dijkstra, B. W., 2016, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 72, 3, p. 244-250

Research output: Contribution to journalArticleAcademicpeer-review

Monophenol Monooxygenase
Agaricales
Lectins
Carrier Proteins
Crystal structure
8 Citations (Scopus)
glycation
Lactose
whey protein
lactose
Digestion
30 Citations (Scopus)

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

Van Broekhoven, S., Bastiaan-Net, S., De Jong, N. W. & Wichers, H. J., 2016, In : Food Chemistry. 196, p. 1075-1083

Research output: Contribution to journalArticleAcademicpeer-review

Tenebrio
dust mites
in vitro digestion
cross reaction
Pyroglyphidae

Intestinal epithelial integrity depends on mitochondrial energy production

Janssen Duijghuijsen, L. M., Grefte, S., van Norren, K., de Boer, V. C. J., van Dartel, D. A. M., Witkamp, R. F., Wichers, H. J. & Keijer, J., 24 Nov 2016.

Research output: Contribution to conferencePosterAcademic

Intestinal epithelial integrity depends on mitochondrial energy production

Janssen Duijghuijsen, L. M., Grefte, S., van Norren, K., de Boer, V. C. J., van Dartel, D. A. M., Witkamp, R. F., Wichers, H. J. & Keijer, J., 24 Nov 2016.

Research output: Contribution to conferenceAbstractAcademic

18 Citations (Scopus)

Large-scale recombinant expression and purificatoin of human tyrosinase suitabel for structural studies

Lai, X., Soler-Lopez, M., Wichers, H. J. & Dijkstra, B., 2016, In : PLoS ONE. 11, 8, 16 p., e0161697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Monophenol Monooxygenase
melanin
albino
skin (animal)
Melanins