19952019

Research output per year

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Research Output

2013

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

van Diepen, J. A., Stienstra, R., Vroegrijk, I. O. C. M., van den Berg, S. A. A., Salvatori, D., Hooiveld, G. J. E. J., Kersten, A. H., Tack, C. J., Netea, M. G., Smit, J. W. A., Joosten, L. A. B., Havekes, L. M., van Dijk, K. W. & Rensen, P. C. N., 2013, In : Journal of Lipid Research. 54, 2, p. 448-456

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Cell- and Tissue-Specific Transcriptome Analyses of Medicago truncatula Root Nodules

Limpens, E. H. M., Moling, S., Hooiveld, G. J., Pereira, P. A., Bisseling, T., Becker, J. D. & Küster, H., 2013, In : PLoS ONE. 8, 5, e64377.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
47 Citations (Scopus)

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

den Besten, G., Lange, K., Havinga, R., van Dijk, T. H., Gerding, A., van Eunen, K., Müller, M. R., Groen, A. K., Hooiveld, G. J. E. J., Bakker, B. M. & Reijngoud, D. J., 2013, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 305, G900-G910

Research output: Contribution to journalArticleAcademicpeer-review

143 Citations (Scopus)

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

Bosma, M., Sparks, L. M., Hooiveld, G. J. E. J., Jorgensen, J. A., Houten, S. M., Schrauwen, P., Kersten, A. H. & Hesselink, M. K. C., 2013, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1831, 4, p. 844-852

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)

Resistant Starch Induces Catabolic but Suppresses Immune and Cell Division Pathways and Changes the Microbiome in Proximal Colon of Male Pigs

Haenen, D., Souza Da Silva, C., Zhang, J., Koopmans, S. J., Bosch, G., Vervoort, J. J. M., Gerrits, W. J. J., Kemp, B., Smidt, H., Müller, M. R. & Hooiveld, G. J. E. J., 2013, In : The Journal of Nutrition. 143, 12, p. 1889-1898

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Short chain fatty acids stimulate Angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating PPARy

Alex, S., Lange, K., Amolo, T., Grinstead, J. S., Haakonsson, A. K., Szalowska, E., Koppen, A., Mudde, C. M., Haenen, D., Al-Lahham, S., Roelofsen, H., Houtman, R., van der Burg, B., Mandrup, S., Bonvin, A. M. J. J., Kalkhoven, E., Muller, M. R., Hooiveld, G. J. E. J. & Kersten, A. H., 2013, In : Molecular and Cellular Biology. 33, 7, p. 1303-1316

Research output: Contribution to journalArticleAcademicpeer-review

87 Citations (Scopus)

The gut microbiota and mucosal homeostasis: Colonized at birth or at adulthood, does it matter?

El-Aidy, S. F., Hooiveld, G. J. E. J., Tremaroli, V., Bäckhed, F. & Kleerebezem, M., 2013, In : Gut Microbes. 4, 2, p. 118-124

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation

El Aidy, S., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Holmes, E., Claus, S. P., Reijngoud, D. J. & Kleerebezem, M., 2013, In : Gut. 62, p. 1306-1314

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)
2012
Open Access

Dietary Protein Affects Gene Expression and Prevents Lipid Accumulation in the Liver in Mice

Schwarz, J., Tome, D. G., Baars, A., Hooiveld, G. J. E. J. & Müller, M. R., 2012, In : PLoS ONE. 7, 10, e47303.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
44 Citations (Scopus)

Oit/Fam3D, a gut secreted protein displaying nutritional status-dependent regulation

de Wit, N. J. W., IJssenagger, N., Oosterink, E., Keshtkar, S., Hooiveld, G. J. E. J., Mensink, R. P., Hammer, S., Smit, J. W. A., Muller, M. R. & van der Meer, R., 2012, In : Journal of Nutritional Biochemistry. 23, 11, p. 1425-1433 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Resistant starch modulates colonic gene expressions and plasma responses in pigs

Haenen, D., Souza Da Silva, C., Bosch, G., Koopmans, S. J., Gerrits, W. J. J., Kemp, B., Muller, M. & Hooiveld, G. J. E. J., 2012.

Research output: Contribution to conferenceAbstractAcademic

Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice

El Aidy, S., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Samsom, J. N., Nieuwenhuis, E. E. S. & Kleerebezem, M., 2012, In : Mucosal Immunology. 5, p. 567-579

Research output: Contribution to journalArticleAcademicpeer-review

117 Citations (Scopus)
2011

Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice

de Wit, N. J. W., Boekschoten, M. V., Machmair, E. M., Hooiveld, G. J. E. J., de Groot, P. J., Rubio-Aliaga, I., Daniel, H. & Muller, M. R., 2011, In : PLoS ONE. 6, 4, 7 p., e19145.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
32 Citations (Scopus)
Open Access
190 Citations (Scopus)

Inflammasome is a central player in the induction of obesity and insulin resistance

Stienstra, R., van Diepen, J. A., Tack, C. J., Zaki, M. H., van de Veerdonk, F. L., Perera, D., Neale, G. A., Hooiveld, G. J. E. J., Hijmans, A., Vroegrijk, I., Berg, S., Romijn, J., Rensen, P. C. N., Joosten, L. A. B., Netea, M. G. & Kanneganti, T. D., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 37, p. 15324-15329

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
382 Citations (Scopus)

Influence of dietary resistant starch on the porcine microbial composition and activity in relation to satiety

Perez, O., Bosch, G., Haenen, D., Souza Da Silva, C., Hooiveld, G. J. E. J. & Smidt, H., 2011.

Research output: Contribution to conferencePosterProfessional

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

Derrien, M. M. N., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E., Müller, M. & de Vos, W. M., 2011, In : Frontiers in Microbiology. 2, 166.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
196 Citations (Scopus)

Strigolactone Biosynthesis in Medicago truncatula and Rice Requires the Symbiotic GRAS-Type Transcription Factors NSP1 and NSP2

Liu, W., Kohlen, W., Lillo, A., op den Camp, R., Ivanov, S., Hartog, M., Limpens, E. H. M., Jamil, M., Smaczniak, C., Kaufmann, K., Yang, W. C., Hooiveld, G. J. E. J., Charnikhova, T., Bouwmeester, H. J., Bisseling, T. & Geurts, R., 2011, In : The Plant Cell. 23, 10, p. 3853-3865

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
168 Citations (Scopus)

Systems biology of Host-Food-Microbe interactions in the mammalian gut

Martins Dos Santos, V. A. P., Müller, M. R., de Vos, W. M., Wells, J., te Pas, M. F. W., Hooiveld, G. J., van Baarlen, P., Smits, M. A. & Keijer, J., 2011, Systems Biology and Livestock Science. te Pas, M. (ed.). John Wiley and Sons, p. 109-135 332 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2010

Absorption, distribution and biliary excretion of cafestol, a potent cholesterol elevating compound in unfiltered coffees in mice

van Cruchten, S. T. J., de Waart, D. R., Kunne, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Katan, M. B., Oude Elferink, R. P. J. & Witkamp, R. F., 2010, In : Drug Metabolism and Disposition. 38, 4, p. 635-640

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

Lichtenstein, L. L., Mattijssen, F. B. J., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Köster, A., Tamsma, J. T., Tan, N. S., Müller, M. R. & Kersten, A. H., 2010, In : Cell Metabolism. 12, 6, p. 580-592

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
128 Citations (Scopus)

Increasing fish consumption does not affect genotozicity markers in the colon in an intervention study

Pot, G. K., Habermann, N., Majsak-Newman, G., Harvey, L. J., Geelen, A., Witteman, B. J. M., van de Meeberg, P. C., Hart, A. R., Schaafsma, G., Hooiveld, G. J. E. J., Glei, M., Lund, E. K., Pool-Zobel, B. L. & Kampman, E., 2010, In : Carcinogenesis. 31, 6, p. 1087-1091

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2009

Comparative Analysis of Gene Regulation by the Transcription Factor PPARa between Mouse and Human

Rakhshandehroo, M., Hooiveld, G. J. E. J., Müller, M. R. & Kersten, A. H., 2009, In : PLoS ONE. 4, 8, 13 p., e6796.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
164 Citations (Scopus)

Differential NF-κB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance

van Baarlen, P., Troost, F. J., van Hemert, S., van der Meer, C., de Vos, W. M., de Groot, P. J., Hooiveld, G. J. E. J., Brummer, R. J. & Kleerebezem, M., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 7, p. 2371-2376

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
270 Citations (Scopus)

Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet

van Schothorst, E. M., Flachs, P., van Franssen-Hal, N. L. W., Kuda, O., Bunschoten, A., Molthoff, J. W., Vink, C., Hooiveld, G. J. E. J., Kopecky, J. & Keijer, J., 2009, In : BMC Genomics. 10, 11 p., 110.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
43 Citations (Scopus)

Relative power and sample size analysis on gene expression profiling data

van Iterson, M., 't Hoen, P. A. C., Pedotti, P., Hooiveld, G. J. E. J., den Dunnen, J. T., van Ommen, G. J. B., Boer, J. M. & Menezes, R. X., 2009, In : BMC Genomics. 10, 439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
54 Citations (Scopus)

The effect of trans-10, cis-12 conjugated linoleic acid on gene expression profiles related to lipid metabolism in human intestinal-like Caco-2 cells

Murphy, E. F., Hooiveld, G. J. E. J., Müller, M. R., Calogero, R. A. & Cashman, K. D., 2009, In : Genes & Nutrition. 4, 2, p. 103-112

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2008

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine

van den Bosch, H. M., de Wit, N. J. W., Hooiveld, G. J. E. J., Vermeulen, H., van der Veen, J. N., Houten, S. M., Kuipers, F., Müller, M. R. & van der Meer, R., 2008, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 294, 5, p. G1171-G1180

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics

Sanderson-Kjellberg, L. M., de Groot, P. J., Hooiveld, G. J. E. J., Koppen, A., Kalkhoven, E., Müller, M. R. & Kersten, A. H., 2008, In : PLoS ONE. 3, 2, e1681.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
66 Citations (Scopus)

PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.

van den Bosch, H. M., Bünger, M., de Groot, P. J., Bosch-Vermeulen, H., Hooiveld, G. J. E. J. & Müller, M. R., 2008, In : BMC Genomics. 9, 13 p., 231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
48 Citations (Scopus)

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

de Wit, N. J. W., Vermeulen, J. J., de Groot, P. J., Hooiveld, G. J. E. J., Grootte Bromhaar, M. M., Jansen, J., Müller, M. R. & van der Meer, R., 2008, In : BMC Medical Genomics. 1, 16 p., 14.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2007

Conjugated Linoleic Acid Alters Global Gene Expression in Human Intestinal-Like Caco-2 Cells in an Isomer-Specific Manner 1-3

Murphy, E. F., Hooiveld, G. J. E. J., Müller, M. R., Calogero, R. A. & Cashman, K. D., Nov 2007, In : The Journal of Nutrition. 137, 11, p. 2359-2365

Research output: Contribution to journalArticleAcademicpeer-review

Exploration of PPAR functions by microarray technology: A paradigm for nutrigenomics

Bünger, M., Hooiveld, G. J. E. J., Kersten, A. H. & Müller, M. R., 2007, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1771, 8, p. 1046-1064

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

van den Bosch, H. M., Bünger, M., de Groot, P. J., van der Meijde, J., Hooiveld, G. J. E. J. & Müller, M. R., 2007, In : BMC Genomics. 8, 12 p., 267.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

Genome-wide analysis of PPAR Alpha activation in murine small intestine

Bünger, M., van den Bosch, H. M., van der Meijde, J., Kersten, A. H., Hooiveld, G. J. E. J. & Müller, M. R., 2007, In : Physiological genomics. 30, 2, p. 192-204

Research output: Contribution to journalArticleAcademicpeer-review

94 Citations (Scopus)

Soaking and dehulling failed to improve zinc bioavailability from experimentally processed dibou, a thick sorghum porridge

Mitchikpe, C. E. S., Dossa, R. A. M., Hooiveld, G. J. E. J., Hulshof, P. J. M., Nout, M. J. R., van Raaij, J. M. A. & Kok, F. J., 2007.

Research output: Contribution to conferenceAbstractAcademic

Open Access

The Cholesterol-Raising Factor from Coffee Beans, Cafestol, as an Agonist Ligand for the Farnesoid and Pregnane X Receptors

Ricketts, M. L., Boekschoten, M. V., Kreeft, A. J., Hooiveld, G. J. E. J., Moen, C. J. A., Müller, M. R., Frants, R. R., Kasanmoentalib, S., Post, S. M., Princen, H. M. G., Porter, J. G., Katan, M. B., Hofker, M. H. & Moore, D. D., 2007, In : Molecular endocrinology. 21, 7, p. 1603-1616

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

The role of oxidative stress in the differential effects between n - 3 and n - 6 polyunsaturated fatty acids and the protective effects of algal and fish oil in colon carcinogenesis

Alink, G. M., van Beelen, V. A., Aarts, J. M. M. J. G., Bino, R. J., Bosch, H. J., Hooiveld, G. J. E. J., Mooibroek, H., Muller, M. R., Reus, A., Roeleveld, J., Sijtsma, L., Spenkelink, A. & Rietjens, I. M. C. M., 2007, 44th Congress of the European Societies of Toxicology. Vol. 172. p. S60-S61

Research output: Chapter in Book/Report/Conference proceedingConference paper

2006

Conjugated linoleic acid enhances transepithelial calcium transport in human intestinal-like Caco-2 cells: An insight into molecular changes

Murphy, E. F., Jewell, C., Hooiveld, G. J. E. J., Müller, M. R. & Cashman, K. D., 2006, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 74, 5, p. 295-301

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2003

Cafestol, the cholesterol-raising factor from coffee beans, is a ligand for the farnesoid X receptor

Boekschoten, M. V., Hooiveld, G. J. E. J., Kuipers, F., Schouten, E. G., Müller, M. R. & Katan, M. B., 2003.

Research output: Contribution to conferenceAbstractAcademic

Lipid-dependent regulation of transporter gene expression in the small intestine

van den Bosch, H. M., Bünger, M., Hooiveld, G. J. E. J. & Müller, M. R., 2003. 1 p.

Research output: Contribution to conferenceAbstractAcademic

Lipid-dependent regulation of transporter gene expression in the small intestine

van den Bosch, H. M., Bünger, M., Hooiveld, G. J. E. J. & Müller, M. R., 2003.

Research output: Contribution to conferenceAbstractAcademic

Lipid-dependent regulation of transporter gene expression in the small intestine

van den Bosch, H. M., Bünger, M., Hooiveld, G. J. E. J. & Müller, M. R., 2003. 1 p.

Research output: Contribution to conferenceAbstractAcademic

Open Access

The ABC of Canalicular Transport

Hooiveld, G. J. E. J. & Müller, M. R., 2003, Molecular pathogenesis of cholestasis. Trauner, M. & Jansen, P. (eds.). New York: Kluwer Academic/Plenum Publishers, 380 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2002

Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins

Hooiveld, G. J. E. J., Heegsma, J., van Montfoort, J. E., Jansen, P. L. M., Meijer, D. K. F. & Muller, M., 2002, In : British Journal of Pharmacology. 135, p. 1685-1694

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)
1996

Neonatal induced diabetes mellitus (DM) in rats: changes in thyroid hormone metabolism before DM is manifest.

Schröder-van der Elst, J. P., van der Heide, D., van Bakel, M. E., Hooiveld, G. J. E. J. & Vos, I. H. C., 1996, In : Journal of Endocrinological Investigation. 19, suppl. 6, p. 79

Research output: Contribution to journalAbstractAcademic

1995

Early effects of neonatal diabetes on thyroid hormone dependent parameters in the rat.

van der Heide, D., Schöder-van der Elst, J. P., Versloot, P. M., Viets, T. C., Bakel, M. E., Hooiveld, G. J. E. J. & Vos, I. H. C., 1995, In : Thyroid. 5, Suppl. 1, p. S252

Research output: Contribution to journalAbstractAcademic