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Research Output 1988 2018

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Article
2018
2 Citations (Scopus)

Distinct Roles of Non-Overlapping Surface Regions of the Coiled-Coil Domain in the Potato Immune Receptor Rx1

Slootweg, E. J., Spiridon, L. N., Martin, E. C., Tameling, W. I. L., Townsend, P. D., Pomp, R., Roosien, J., Drawska, O., Sukarta, O. C. A., Schots, A., Borst, J. W., Joosten, M. H. A. J., Bakker, J., Smant, G., Cann, M. J., Petrescu, A-J. & Goverse, A., Nov 2018, In : Plant Physiology. 178, 3, p. 1310-1331

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
AIDS-Related Complex
Solanum tuberosum
Leucine
leucine
cell death

Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses

Wilbers, R. H. P., Westerhof, L. B., Van Raaij, D. R., Bakker, J., Smant, G. & Schots, A., Apr 2018, In : Future Science OA. 14, 4, 10.4155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-10
Cytokines
Dendritic Cells
Lipopolysaccharides
3 Citations (Scopus)

Nicotiana benthamianaα-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease

Kytidou, K., Beekwilder, J., Artola, M., van Meel, E., Wilbers, R. H. P., Moolenaar, G. F., Goosen, N., Ferraz, M. J., Katzy, R., Voskamp, P., Florea, B. I., Hokke, C. H., Overkleeft, H. S., Schots, A., Bosch, D., Pannu, N. & Aerts, J. M. F. G., 29 Jun 2018, In : Journal of Biological Chemistry. 293, 26, p. 10042-10058

Research output: Contribution to journalArticleAcademicpeer-review

Galactosidases
Fabry Disease
Tobacco
Enzyme Replacement Therapy
Glycosphingolipids
2017
5 Citations (Scopus)

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Kytidou, K., Beenakker, T. J. M., Westerhof, L. B., Hokke, C. H., Moolenaar, G. F., Goosen, N., Mirzaian, M., Ferraz, M. J., De Geus, M., Kallemeijn, W. W., Overkleeft, H. S., Boot, R. G., Schots, A., Bosch, D. & Aerts, J. M. F. G., 2017, In : Frontiers in Plant Science. 8, 1026.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
alpha-galactosidase
Nicotiana benthamiana
substrate specificity
galactosidases
enzymes
17 Citations (Scopus)

Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants

Wilbers, R. H. P., Westerhof, L. B., Van Noort, K., Obieglo, K., Driessen, N. N., Everts, B., Gringhuis, S. I., Schramm, G., Goverse, A., Smant, G., Bakker, J., Smits, H. H., Yazdanbakhsh, M., Schots, A. & Hokke, C. H., 2017, In : Scientific Reports. 7, 45910.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Helminths
Glycoproteins
Glycosylation
Parasites
Communicable Disease Control
4 Citations (Scopus)

Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain

Wilbers, R. H. P., Van Raaij, D. R., Westerhof, L. B., Bakker, J., Smant, G. & Schots, A., 2017, In : PLoS ONE. 12, 10, e0186317.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
interleukin-10
Interleukin-10
Interleukin-10 Receptors
Bone Marrow
Interleukin-10 Receptor alpha Subunit
14 Citations (Scopus)

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Haeberlein, S., Obieglo, K., Ozir-Fazalalikhan, A., Chayé, M. A. M., Veninga, H., van der Vlugt, L. E. P. M., Voskamp, A., Boon, L., den Haan, J. M. M., Westerhof, L. B., Wilbers, R. H. P., Schots, A., Schramm, G., Hokke, C. H. & Smits, H. H., 2017, In : PLoS Pathogens. 13, 7, e1006539.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Regulatory B-Lymphocytes
Ovum
Glycoproteins
Antigens
B-Lymphocytes
6 Citations (Scopus)

Sequence exchange between R genes converts virus resistance into nematode resistance, and vice versa

Slootweg, E. J., Koropacka, K. B., Roosien, J., Dees, R., Overmars, H., Klein Lankhorst, R., van Schaik, C., Pomp, R., Bouwman-Smits, L., Helder, H., Schots, A., Bakker, J., Smant, G. & Goverse, A., 2017, In : Plant Physiology. 175, p. 498-510

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Potexvirus
vpr Genes
AIDS-Related Complex
Solanum tuberosum
Switch Genes
2016
9 Citations (Scopus)

Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-b1 into a biologically active protein

Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., van Adrichem, M., Prakasa, A. D., Lozano Torres, J. L., Bakker, J., Smant, G. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 8, p. 1695-1704

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Furin
transforming growth factor beta 1
transforming growth factors
Nicotiana benthamiana
Transforming Growth Factors
2 Citations (Scopus)

Physical Interaction of T Cells with Dendritic Cells Is Not Required for the Immunomodulatory Effects of the Edible Mushroom Agaricus subrufescens

Wilbers, R. H. P., Westerhof, L. B., van de Velde, J., Smant, G., Valkenburg-van Raaij, D., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2016, In : Frontiers in Immunology. 7, 519.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Agaricus
Agaricales
Dendritic Cells
T-Lymphocytes
C-Type Lectins
5 Citations (Scopus)

The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity

Wilbers, R. H. P., Westerhof, L. B., Reuter, L. J., Castilho, A., van Raaij, D. R., Nguyen, D., Lozano Torres, J. L., Smant, G., Hokke, C. H., Bakker, J. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 2, p. 670-681

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
chemical constituents of plants
interleukins
Polysaccharides
polysaccharides
glycosylation
4 Citations (Scopus)

Transient expression of secretory IgA in planta is optimal using a multi-gene vector and may be further enhanced by improving joining chain incorporation

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., van Wijk, M., Goverse, A., Bakker, J. & Schots, A., 2016, In : Frontiers in Plant Science. 6, 12 p., 1200.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Plantae
antibodies
genes
inflammatory bowel disease
interleukin-12
2015
2 Citations (Scopus)

Assessing the immunomodulatory potential of high-molecular-weight extracts from mushrooms; an assay based on THP-1 macrophages

van de Velde, J., Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., Stavrakaki, I., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2015, In : Journal of the Science of Food and Agriculture. 95, 2, p. 344-350

Research output: Contribution to journalArticleAcademicpeer-review

Agaricales
mushrooms
macrophages
Molecular Weight
Macrophages
2014
49 Citations (Scopus)

Apoplastic Venom Allergen-like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., Diaz Granados Muñoz, A., van Schaik, C. C., Helder, J., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014, In : PLoS Pathogens. 10, 12, 18 p., e1004569.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Plant Immunity
Venoms
Cell Surface Receptors
Innate Immunity
Allergens
14 Citations (Scopus)

Monomeric IgA can be produced in planta as efficient as IgG, yet receives different N-glycans

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., Nguyen, D., Goverse, A., Henquet, M. G. L., Hokke, C. H., Bosch, D., Bakker, J. & Schots, A., 2014, In : Plant Biotechnology Journal. 12, 9, p. 1333-1342

Research output: Contribution to journalArticleAcademicpeer-review

Plantae
Immunoglobulin A
Polysaccharides
polysaccharides
Immunoglobulin G
2013
70 Citations (Scopus)

N-Glycosylation of Plant-produced Recombinant Proteins

Bosch, H. J., Castilho, A., Loos, A., Schots, A. & Steinkeller, H., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5503-5512

Research output: Contribution to journalArticleAcademicpeer-review

Glycosylation
Recombinant Proteins
Polysaccharides
Aptitude
Post Translational Protein Processing
2012
13 Citations (Scopus)

3D Domain Swapping Causes Extensive Multimerisation of Human Interleukin-10 When Expressed In Planta

Westerhof, L. B., Wilbers, R. H. P., Roosien, J., van de Velde, J., Goverse, A., Bakker, J. & Schots, A., 2012, In : PLoS ONE. 7, 10, 10 p., e46460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
interleukin-10
Plantae
Interleukin-10
Proteins
cytokines
136 Citations (Scopus)

Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode

Lozano, J., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A. M., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10119-10124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
disease resistance
virulence
Nematoda
tomatoes
Solanum pimpinellifolium
2010
103 Citations (Scopus)

Nucleocytoplasmic distribution is required for activation of resistance by the potato NB-LRR receptor Rx1 and is balanced by its functional domains

Slootweg, E. J., Roosien, J., Spiridon, L. N., Petrescu, A. J., Tameling, W. I. L., Joosten, M. H. A. J., Pomp, H., van Schaik, C. C., Dees, R. H. L., Borst, J. W., Smant, G., Schots, A., Bakker, J. & Goverse, A., 2010, In : The Plant Cell. 22, 12, p. 4195-4215

Research output: Contribution to journalArticleAcademicpeer-review

Solanum tuberosum
Cytoplasm
Nucleotides
cytoplasm
nucleotides
47 Citations (Scopus)

Plant glycans: friend or foe in vaccine development?

Bosch, H. J. & Schots, A., 2010, In : Expert Review Vaccines. 9, 8, p. 835-842

Research output: Contribution to journalArticleAcademicpeer-review

Polysaccharides
Vaccines
Antigen-Presenting Cells
Glycosylation
Subunit Vaccines
50 Citations (Scopus)

Successive immunoglobulin and cytokine expression in the small intestine of juvenile chicken

Lammers, A., Wieland, W. H., Kruijt, L., Jansma, A., Straetemans, T., Schots, A., den Hartog, C. G. & Parmentier, H. K., 2010, In : Developmental and Comparative Immunology. 34, 12, p. 1254-1262 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin A
Small Intestine
Immunoglobulins
Chickens
Cytokines
2006
43 Citations (Scopus)

A symbiont-independent endo-1,4-beta-xylanase from the plant-parasitic nematode Meloidogyne incognita

Mitreva-Dautova, M., Roze, E. H. A., Overmars, H. A., de Graaff, L. H., Schots, A., Helder, J., Goverse, A., Bakker, J. & Smant, G., 2006, In : Molecular Plant-Microbe Interactions. 19, 5, p. 521-529

Research output: Contribution to journalArticleAcademicpeer-review

endo-1,4-beta-xylanase
Tylenchoidea
Endo-1,4-beta Xylanases
Xylans
xylan
9 Citations (Scopus)

Display and selection of chicken IgA Fab fragments

Wieland, W. H., Orzaéz, D., Lammers, A., Parmentier, H. K. & Schots, A., 2006, In : Veterinary Immunology and Immunopathology. 110, 1-2, p. 129-140

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin Fab Fragments
Immunoglobulin A
Chickens
chickens
Eimeria acervulina
7 Citations (Scopus)

Fluorescent T7 display phages obtained by translational frameshift

Slootweg, E. J., Keller, H. J. H. G., Hink, M. A., Borst, J. W., Bakker, J. & Schots, A., 2006, In : Nucleic acids research. 34, 20, 11 p., e137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bacteriophage T7
Capsid Proteins
Bacteriophages
Gene Library
Fluorescence Microscopy
26 Citations (Scopus)

Plant expression of chicken secretory antibodies derived from combinatorial libraries

Wieland, W. H., Lammers, A., Schots, A. & Orzaéz, D. V., 2006, In : Journal of Biotechnology. 122, 3, p. 382-391 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Secretory Immunoglobulin A
Antibodies
Chickens
Immunoglobulin A
Secretory Component
2005
9 Citations (Scopus)

Epitope identification and in silico prediction of the specificity of antibodies binding to the coat proteins of Potato Virus Y strains

Keller, H. J. H. G., Pomp, H., Bakker, J. & Schots, A., 2005, In : European Journal of Plant Pathology. 111, 4, p. 391-397

Research output: Contribution to journalArticleAcademicpeer-review

Potato virus Y
coat proteins
epitopes
DNA libraries
antibodies
17 Citations (Scopus)

Isolation of recombinant antibodies (scFvs) to grapevine virus B

Saldarelli, P., Keller, H. J. H. G., Dell'Orco, M., Schots, A., Elicio, V. & Minafra, A., 2005, In : Journal of Virological Methods. 124, 1-2, p. 191-195

Research output: Contribution to journalArticleAcademicpeer-review

Cercopithecine Herpesvirus 1
Single-Chain Antibodies
amsonic acid
Antibodies
Cell Surface Display Techniques
32 Citations (Scopus)

Phage display-selected single chain antibodies confer high levels of resistance against Tomato spotted wilt virus

Prins, M. W., Lohuis, H., Schots, A. & Goldbach, R. W., 2005, In : Journal of General Virology. 86, 7, p. 2107-2113

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Tospovirus
Single-Chain Antibodies
Bacteriophages
Plant Viruses
Antibodies
2004
76 Citations (Scopus)

A functional polymeric immunoglobulin receptor in chicken (Gallus gallus) indicates ancient role of secretory IgA in mucosal immunity

Wieland, W. H., Orzaéz Calatayud, D. V., Lammers, A., Parmentier, H. K., Verstegen, M. W. A. & Schots, A., 2004, In : Biochemical Journal. 380, 3, p. 669-676

Research output: Contribution to journalArticleAcademicpeer-review

Polymeric Immunoglobulin Receptors
Secretory Immunoglobulin A
Mucosal Immunity
Chickens
Genes
17 Citations (Scopus)

Design of a confocal microfluidic particle sorter using fluorescent photon burst detection

Kunst, B. H., Schots, A. & Visser, A. J. W. G., 2004, In : Review of Scientific Instruments. 75, 9, p. 2892-2898

Research output: Contribution to journalArticleAcademicpeer-review

classifying
Sorting
Microfluidics
Biochips
bursts
8 Citations (Scopus)

Towards sorting of biolibraries using single-molecule fluorescence detection techniques

Visser, A. J. W. G., Kunst, B. H., Keller, H. J. H. G. & Schots, A., 2004, In : Current Pharmaceutical Biotechnology. 5, p. 173-179

Research output: Contribution to journalArticleAcademicpeer-review

Fluorescence
Microfluidics
Photons
Bacteriophages
Equipment and Supplies