1988 …2018

Research output per year

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Research Output

2018

Apoplastic venom allergen-like proteins of plant-parasitic nematodes modulate the activation of plant innate immunity by cell surface receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Varossieau, K., Willig, J., van Schaik, C. C., Asojo, O. A., Darwiche, R., Schneiter, R., Drurey, C., Maizels, R. M., Goverse, A., Schots, A. & Smant, G., 13 Sep 2018.

Research output: Contribution to conferenceAbstractAcademic

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of 'native' helminth N-glycan structures in planta

van Noort, K., Nguyen, D-L., Hokke, C., Schots, A. & Wilbers, R. H. P., 13 Jun 2018.

Research output: Contribution to conferencePosterAcademic

Distinct Roles of Non-Overlapping Surface Regions of the Coiled-Coil Domain in the Potato Immune Receptor Rx1

Slootweg, E. J., Spiridon, L. N., Martin, E. C., Tameling, W. I. L., Townsend, P. D., Pomp, R., Roosien, J., Drawska, O., Sukarta, O. C. A., Schots, A., Borst, J. W., Joosten, M. H. A. J., Bakker, J., Smant, G., Cann, M. J., Petrescu, A-J. & Goverse, A., Nov 2018, In : Plant Physiology. 178, 3, p. 1310-1331

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses

Wilbers, R. H. P., Westerhof, L. B., Van Raaij, D. R., Bakker, J., Smant, G. & Schots, A., Apr 2018, In : Future Science OA. 14, 4, 10.4155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nicotiana benthamianaα-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease

Kytidou, K., Beekwilder, J., Artola, M., van Meel, E., Wilbers, R. H. P., Moolenaar, G. F., Goosen, N., Ferraz, M. J., Katzy, R., Voskamp, P., Florea, B. I., Hokke, C. H., Overkleeft, H. S., Schots, A., Bosch, D., Pannu, N. & Aerts, J. M. F. G., 29 Jun 2018, In : Journal of Biological Chemistry. 293, 26, p. 10042-10058

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2017

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Kytidou, K., Beenakker, T. J. M., Westerhof, L. B., Hokke, C. H., Moolenaar, G. F., Goosen, N., Mirzaian, M., Ferraz, M. J., De Geus, M., Kallemeijn, W. W., Overkleeft, H. S., Boot, R. G., Schots, A., Bosch, D. & Aerts, J. M. F. G., 2017, In : Frontiers in Plant Science. 8, 1026.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Mimicking immunomodulatory helminth glycoproteins in plants to enable treatment of inflammatory diseases

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Obieglo, K., Driessen, N. N., Everts, B., Goverse, A., Smant, G., Bakker, J., Smits, H. H., Yazdanbakhsh, M., Schots, A. & Hokke, C. H., Feb 2017.

Research output: Contribution to conferencePosterAcademic

Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants

Wilbers, R. H. P., Westerhof, L. B., Van Noort, K., Obieglo, K., Driessen, N. N., Everts, B., Gringhuis, S. I., Schramm, G., Goverse, A., Smant, G., Bakker, J., Smits, H. H., Yazdanbakhsh, M., Schots, A. & Hokke, C. H., 2017, In : Scientific Reports. 7, 45910.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
21 Citations (Scopus)

Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain

Wilbers, R. H. P., Van Raaij, D. R., Westerhof, L. B., Bakker, J., Smant, G. & Schots, A., 2017, In : PLoS ONE. 12, 10, e0186317.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Haeberlein, S., Obieglo, K., Ozir-Fazalalikhan, A., Chayé, M. A. M., Veninga, H., van der Vlugt, L. E. P. M., Voskamp, A., Boon, L., den Haan, J. M. M., Westerhof, L. B., Wilbers, R. H. P., Schots, A., Schramm, G., Hokke, C. H. & Smits, H. H., 2017, In : PLoS Pathogens. 13, 7, e1006539.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
21 Citations (Scopus)

Sequence exchange between R genes converts virus resistance into nematode resistance, and vice versa

Slootweg, E. J., Koropacka, K. B., Roosien, J., Dees, R., Overmars, H., Klein Lankhorst, R., van Schaik, C., Pomp, R., Bouwman-Smits, L., Helder, H., Schots, A., Bakker, J., Smant, G. & Goverse, A., 2017, In : Plant Physiology. 175, p. 498-510

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)
2016

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., Westerhof, L. B., Hokke, C. H., Smant, G., Bakker, J. & Schots, A., 2016.

Research output: Contribution to conferencePosterAcademic

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., ter Horst, K., Westerhof, L. B., Hokke, C. H., Smant, G., Bakker, J. & Schots, A., 16 Oct 2016.

Research output: Contribution to conferencePosterAcademic

Open Access

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., Westerhof, L. B., Hokke, C. H., Smant, G., Bakker, J. & Schots, A., 2016.

Research output: Contribution to conferencePosterAcademic

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., Westerhof, L. B. & Schots, A., Oct 2016.

Research output: Contribution to conferenceAbstractAcademic

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., Westerhof, L. B. & Schots, A., May 2016.

Research output: Contribution to conferenceAbstractAcademic

Codon use and mRNA structure analyses across kingdoms indicates selection on both mRNA stability and translatability

Westerhof, L. B., Sterken, M. G., Wilbers, R. H. P., Luijben, L., van Raaij, D. R., Snoek, L. B., Bakker, J. & Schots, A., 25 May 2016. 1 p.

Research output: Contribution to conferenceAbstractAcademic

Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-b1 into a biologically active protein

Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., van Adrichem, M., Prakasa, A. D., Lozano Torres, J. L., Bakker, J., Smant, G. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 8, p. 1695-1704

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Engineering of plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Nguyen, D. L., Smant, G., Bakker, J., Hokke, C. H. & Schots, A., 2016. 1 p.

Research output: Contribution to conferencePosterAcademic

Engineering of plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Nguyen, D. L., Smant, G., Bakker, J., Hokke, C. H. & Schots, A., 2016. 1 p.

Research output: Contribution to conferencePosterAcademic

Mushroom immunomodulation and germplasm: variation between and within mushroom species and perspectives for application.

Schots, A., Wilbers, R. H. P., Westerhof, L. B., van Esch, B. C. A. M., Garssen, J. & Sonnenberg, A. S. M., 2016, Science and Cultivation of Edible Fungi: Proceedings of the XIXth int. congress on the science and cultivatio of edible and medicinal fungi/Amsterdam/The Netherlands/30 may-2 june 2016. Baars, J. J. P. & Sonnenberg, A. S. M. (eds.). International Society for Mushroom Science (ISMS), p. 281-284

Research output: Chapter in Book/Report/Conference proceedingConference paper

Physical Interaction of T Cells with Dendritic Cells Is Not Required for the Immunomodulatory Effects of the Edible Mushroom Agaricus subrufescens

Wilbers, R. H. P., Westerhof, L. B., van de Velde, J., Smant, G., Valkenburg-van Raaij, D., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2016, In : Frontiers in Immunology. 7, 519.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity

Wilbers, R. H. P., Westerhof, L. B., Reuter, L. J., Castilho, A., van Raaij, D. R., Nguyen, D., Lozano Torres, J. L., Smant, G., Hokke, C. H., Bakker, J. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 2, p. 670-681

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Transient expression of secretory IgA in planta is optimal using a multi-gene vector and may be further enhanced by improving joining chain incorporation

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., van Wijk, M., Goverse, A., Bakker, J. & Schots, A., 2016, In : Frontiers in Plant Science. 6, 12 p., 1200.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)
2015

Assessing the immunomodulatory potential of high-molecular-weight extracts from mushrooms; an assay based on THP-1 macrophages

van de Velde, J., Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., Stavrakaki, I., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2015, In : Journal of the Science of Food and Agriculture. 95, 2, p. 344-350

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Engineering plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., Everts, B., van Noort, K., van Raaij, D. R., Nguyen, D., Yazdanbakhsh, M., Hokke, C. H. & Schots, A., 2015.

Research output: Contribution to conferencePosterProfessional

2014

Apoplastic Venom Allergen-like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., Diaz Granados Muñoz, A., van Schaik, C. C., Helder, J., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014, In : PLoS Pathogens. 10, 12, 18 p., e1004569.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
52 Citations (Scopus)

Biological activity of human interleukin-22 expressed in Nicotiana benthamiana is independent of its N-glycosylation

Wilbers, R. H. P., Westerhof, L. B., Reuter, L. J., Castilho, A., van Raaij, D. R., Smant, G., Bakker, J. & Schots, A., 2014, Proceedings of The First Conference of the International Society for Plant Molecular Farming. p. 76-76

Research output: Chapter in Book/Report/Conference proceedingAbstract

Expression of Schistosome-derived Omega-1 with diantennary glycans carrying Lewis X motifs in Nicotiana benthamiana plants

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., Capuder, E., van der Schuren, A., Nguyen, D., Hussaarts, L., Driessen, N., Hokke, C., Yazdanbakhsh, M., Bosch, D. & Schots, A., 2014, Proceedings of The First Conference of the International Society for Plant Molecular Farming. p. 22-22

Research output: Chapter in Book/Report/Conference proceedingAbstract

Expression of Schistosome-derived Omega-1 with diantennary N-glycans carrying Lewis X motifs in Nicotiana benthamiana plants

Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., Capuder, E., van der Schuren, A., Nguyen, D., Hussaarts, L., Driessen, N., Hokke, C. H., Yazdanbakhsh, M., Bosch, D. & Schots, A., 2014, Proceedings of Molecular and Cellular Biology of Helminths VIII. p. 66-66

Research output: Chapter in Book/Report/Conference proceedingAbstract

Monomeric IgA can be produced in planta as efficient as IgG, yet receives different N-glycans

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., Nguyen, D., Goverse, A., Henquet, M. G. L., Hokke, C. H., Bosch, D., Bakker, J. & Schots, A., 2014, In : Plant Biotechnology Journal. 12, 9, p. 1333-1342

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Secreted venom allergen-like proteins of plant-parasitic nematodes modulate defence responses in host plants

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Overmars, H. A., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014, Proceedings of the 6th International Congress of Nematology, 4-9 May 2014, Cape Town, South Africa. p. 72-72

Research output: Chapter in Book/Report/Conference proceedingAbstract

Secreted venom allergen-like proteins of plant-parasitic nematodes modulate host defence responses in plants

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Overmars, H. A., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014.

Research output: Contribution to conferencePosterProfessional

2013

N-Glycosylation of Plant-produced Recombinant Proteins

Bosch, H. J., Castilho, A., Loos, A., Schots, A. & Steinkeller, H., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5503-5512

Research output: Contribution to journalArticleAcademicpeer-review

74 Citations (Scopus)

Secreted venom allergen-like proteins of plant-parasitic nematodes modulate defence responses in host plants

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Overmars, H. A., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2013, Proceedings of 1st Annual Meeting, COST FA 1208, 09-11 October 2013, Birnam, Scotland. p. 32-32

Research output: Chapter in Book/Report/Conference proceedingAbstract

Venom allergen-like proteins secreted by plant-parasitic nematodes modulate defense responses mediated by extracellular innate immune receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2013, Proceedings of 1st Annual Meeting, COST FA 1208, 09-11 October 2013, Birnam, Scotland. p. 46-46

Research output: Chapter in Book/Report/Conference proceedingAbstract

2012

3D Domain Swapping Causes Extensive Multimerisation of Human Interleukin-10 When Expressed In Planta

Westerhof, L. B., Wilbers, R. H. P., Roosien, J., van de Velde, J., Goverse, A., Bakker, J. & Schots, A., 2012, In : PLoS ONE. 7, 10, 10 p., e46460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

A nematode venom allergen/ASP-like protein is required for plant-parasitism and induces a hypersensitive response through an extracellular leucine-rich repeat receptor

Lozano Torres, J. L., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, Proceedings of the Molecular and cellular biology of helminth parasites VII, 02- 09 September 2012, Hydra, Greece. p. 31-31

Research output: Chapter in Book/Report/Conference proceedingAbstract

Dual Cf-2-mediated disease resistance in tomato requires a common virulence target of a fungus and a nematode

Lozano Torres, J. L., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A. M., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, Immunomodulation by plant-associated organisms, Fallen Leaf Lake, California, USA, 16-19 September 2012. Fallen Leaf Lake, California, USA, p. 68-68

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode

Lozano, J., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A. M., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10119-10124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
139 Citations (Scopus)

Resolving 3D-domain swapping of human IL-10 prevents extensive multimerisation and increases yield

Westerhof, L. B., Wilbers, R. H. P., Roosien, J., Bakker, J. & Schots, A., 2012, Molecular farming: plants as production platform for high value proteins. Warsaw, p. 27-27

Research output: Chapter in Book/Report/Conference proceedingAbstract

2011

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Wilbers, R. H. P., Westerhof, L. B. & Schots, A., 2011.

Research output: Contribution to conferencePosterProfessional

Bananen met een aidsvaccin?

Bosch, H. J. & Schots, A., 2011, NIBI-conferentie : Kunnen we het maken?. Lunteren: NIBI, p. 49-49

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

Fungal polysaccharides recognized by animal immune cells differentially induce Th17 and Th1 responses

van de Velde, J., Oostindie, S., Peters, R. & Schots, A., 2011, Proceedings of the Autumn School 'Host-Microbe Interactomics, Wageningen, the Netherlands, 01-11-2011. Wageningen: PhD Autumn School, p. 19-19

Research output: Chapter in Book/Report/Conference proceedingAbstract

2010

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Westerhof, L. B., Wilbers, R. H. P. & Schots, A., 2010.

Research output: Contribution to conferenceAbstractAcademic

Open Access

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Wilbers, R. H. P., Westerhof, L. B. & Schots, A., 2010.

Research output: Contribution to conferencePosterProfessional

Aggregation as a bottleneck for interleukin-10 production in Nicotiana benthamiana

Westerhof, L. B., Wilbers, R. H. P. & Schots, A., 2010.

Research output: Contribution to conferenceAbstractAcademic

Open Access