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Research Output 1988 2018

2018

Apoplastic venom allergen-like proteins of plant-parasitic nematodes modulate the activation of plant innate immunity by cell surface receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Varossieau, K., Willig, J., van Schaik, C. C., Asojo, O. A., Darwiche, R., Schneiter, R., Drurey, C., Maizels, R. M., Goverse, A., Schots, A. & Smant, G., 13 Sep 2018.

Research output: Contribution to conferenceAbstractAcademic

venoms
plant parasitic nematodes
allergens
receptors
Nematoda
2 Citations (Scopus)

Distinct Roles of Non-Overlapping Surface Regions of the Coiled-Coil Domain in the Potato Immune Receptor Rx1

Slootweg, E. J., Spiridon, L. N., Martin, E. C., Tameling, W. I. L., Townsend, P. D., Pomp, R., Roosien, J., Drawska, O., Sukarta, O. C. A., Schots, A., Borst, J. W., Joosten, M. H. A. J., Bakker, J., Smant, G., Cann, M. J., Petrescu, A-J. & Goverse, A., Nov 2018, In : Plant Physiology. 178, 3, p. 1310-1331

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
AIDS-Related Complex
Solanum tuberosum
Leucine
leucine
cell death

Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses

Wilbers, R. H. P., Westerhof, L. B., Van Raaij, D. R., Bakker, J., Smant, G. & Schots, A., Apr 2018, In : Future Science OA. 14, 4, 10.4155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-10
Cytokines
Dendritic Cells
Lipopolysaccharides
3 Citations (Scopus)

Nicotiana benthamianaα-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease

Kytidou, K., Beekwilder, J., Artola, M., van Meel, E., Wilbers, R. H. P., Moolenaar, G. F., Goosen, N., Ferraz, M. J., Katzy, R., Voskamp, P., Florea, B. I., Hokke, C. H., Overkleeft, H. S., Schots, A., Bosch, D., Pannu, N. & Aerts, J. M. F. G., 29 Jun 2018, In : Journal of Biological Chemistry. 293, 26, p. 10042-10058

Research output: Contribution to journalArticleAcademicpeer-review

Galactosidases
Fabry Disease
Tobacco
Enzyme Replacement Therapy
Glycosphingolipids
2017
5 Citations (Scopus)

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Kytidou, K., Beenakker, T. J. M., Westerhof, L. B., Hokke, C. H., Moolenaar, G. F., Goosen, N., Mirzaian, M., Ferraz, M. J., De Geus, M., Kallemeijn, W. W., Overkleeft, H. S., Boot, R. G., Schots, A., Bosch, D. & Aerts, J. M. F. G., 2017, In : Frontiers in Plant Science. 8, 1026.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
alpha-galactosidase
Nicotiana benthamiana
substrate specificity
galactosidases
enzymes

Mimicking immunomodulatory helminth glycoproteins in plants to enable treatment of inflammatory diseases

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Obieglo, K., Driessen, N. N., Everts, B., Goverse, A., Smant, G., Bakker, J., Smits, H. H., Yazdanbakhsh, M., Schots, A. & Hokke, C. H., Feb 2017.

Research output: Contribution to conferencePosterAcademic

Helminths
Glycoproteins
Glycosylation
Parasites
Communicable Disease Control
17 Citations (Scopus)

Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants

Wilbers, R. H. P., Westerhof, L. B., Van Noort, K., Obieglo, K., Driessen, N. N., Everts, B., Gringhuis, S. I., Schramm, G., Goverse, A., Smant, G., Bakker, J., Smits, H. H., Yazdanbakhsh, M., Schots, A. & Hokke, C. H., 2017, In : Scientific Reports. 7, 45910.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Helminths
Glycoproteins
Glycosylation
Parasites
Communicable Disease Control
4 Citations (Scopus)

Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain

Wilbers, R. H. P., Van Raaij, D. R., Westerhof, L. B., Bakker, J., Smant, G. & Schots, A., 2017, In : PLoS ONE. 12, 10, e0186317.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
interleukin-10
Interleukin-10
Interleukin-10 Receptors
Bone Marrow
Interleukin-10 Receptor alpha Subunit
14 Citations (Scopus)

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Haeberlein, S., Obieglo, K., Ozir-Fazalalikhan, A., Chayé, M. A. M., Veninga, H., van der Vlugt, L. E. P. M., Voskamp, A., Boon, L., den Haan, J. M. M., Westerhof, L. B., Wilbers, R. H. P., Schots, A., Schramm, G., Hokke, C. H. & Smits, H. H., 2017, In : PLoS Pathogens. 13, 7, e1006539.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Regulatory B-Lymphocytes
Ovum
Glycoproteins
Antigens
B-Lymphocytes
6 Citations (Scopus)

Sequence exchange between R genes converts virus resistance into nematode resistance, and vice versa

Slootweg, E. J., Koropacka, K. B., Roosien, J., Dees, R., Overmars, H., Klein Lankhorst, R., van Schaik, C., Pomp, R., Bouwman-Smits, L., Helder, H., Schots, A., Bakker, J., Smant, G. & Goverse, A., 2017, In : Plant Physiology. 175, p. 498-510

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Potexvirus
vpr Genes
AIDS-Related Complex
Solanum tuberosum
Switch Genes
2016

Apoplastic Venom Allergen-like Proteins of Plant Parasitic Nematodes Modulate the Activation of Plant Innate Immunity by Cell Surface Receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., Diaz Granados Muñoz, A., van Schaik, C. C., Helder, J., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2016, p. 127-127.

Research output: Contribution to conferenceAbstractAcademic

venoms
plant parasitic nematodes
allergens
receptors
Nematoda
venoms
plant parasitic nematodes
allergens
receptors
Nematoda
Schistosoma mansoni
Plantae
helminths
engineering
polysaccharides
Schistosoma mansoni
Plantae
helminths
engineering
polysaccharides
Schistosoma mansoni
Plantae
helminths
engineering
polysaccharides

Characterization of Schistosoma mansoni fucosyltransferases for glyco-engineering of ‘native’ helminth N-glycan structures in planta

van Noort, K., Wilbers, R. H. P., ter Horst, K., Westerhof, L. B., Hokke, C. H., Smant, G., Bakker, J. & Schots, A., 16 Oct 2016.

Research output: Contribution to conferencePosterAcademic

Open Access

Codon use and mRNA structure analyses across kingdoms indicates selection on both mRNA stability and translatability

Westerhof, L. B., Sterken, M. G., Wilbers, R. H. P., Luijben, L., van Raaij, D. R., Snoek, L. B., Bakker, J. & Schots, A., 25 May 2016. 1 p.

Research output: Contribution to conferenceAbstractAcademic

codons
Animalia
genes
proteins
stems
9 Citations (Scopus)

Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-b1 into a biologically active protein

Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., van Adrichem, M., Prakasa, A. D., Lozano Torres, J. L., Bakker, J., Smant, G. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 8, p. 1695-1704

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Furin
transforming growth factor beta 1
transforming growth factors
Nicotiana benthamiana
Transforming Growth Factors

Engineering of plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Nguyen, D. L., Smant, G., Bakker, J., Hokke, C. H. & Schots, A., 2016. 1 p.

Research output: Contribution to conferencePosterAcademic

Helminths
Polysaccharides
Schistosoma mansoni
Glycoproteins
Helminth Proteins

Engineering of plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., van Noort, K., Nguyen, D. L., Smant, G., Bakker, J., Hokke, C. H. & Schots, A., 2016. 1 p.

Research output: Contribution to conferencePosterAcademic

Helminths
Polysaccharides
Glycoproteins
Helminth Proteins
Parasitology

Mushroom immunomodulation and germplasm: variation between and within mushroom species and perspectives for application.

Schots, A., Wilbers, R. H. P., Westerhof, L. B., van Esch, B. C. A. M., Garssen, J. & Sonnenberg, A. S. M., 2016, Science and Cultivation of Edible Fungi: Proceedings of the XIXth int. congress on the science and cultivatio of edible and medicinal fungi/Amsterdam/The Netherlands/30 may-2 june 2016. Baars, J. J. P. & Sonnenberg, A. S. M. (eds.). International Society for Mushroom Science (ISMS), p. 281-284

Research output: Chapter in Book/Report/Conference proceedingConference paper

2 Citations (Scopus)

Physical Interaction of T Cells with Dendritic Cells Is Not Required for the Immunomodulatory Effects of the Edible Mushroom Agaricus subrufescens

Wilbers, R. H. P., Westerhof, L. B., van de Velde, J., Smant, G., Valkenburg-van Raaij, D., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2016, In : Frontiers in Immunology. 7, 519.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Agaricus
Agaricales
Dendritic Cells
T-Lymphocytes
C-Type Lectins
5 Citations (Scopus)

The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity

Wilbers, R. H. P., Westerhof, L. B., Reuter, L. J., Castilho, A., van Raaij, D. R., Nguyen, D., Lozano Torres, J. L., Smant, G., Hokke, C. H., Bakker, J. & Schots, A., 2016, In : Plant Biotechnology Journal. 14, 2, p. 670-681

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
chemical constituents of plants
interleukins
Polysaccharides
polysaccharides
glycosylation
4 Citations (Scopus)

Transient expression of secretory IgA in planta is optimal using a multi-gene vector and may be further enhanced by improving joining chain incorporation

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., van Wijk, M., Goverse, A., Bakker, J. & Schots, A., 2016, In : Frontiers in Plant Science. 6, 12 p., 1200.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Plantae
antibodies
genes
inflammatory bowel disease
interleukin-12
2015
cyst nematodes
venoms
allergens
receptors
proteins
2 Citations (Scopus)

Assessing the immunomodulatory potential of high-molecular-weight extracts from mushrooms; an assay based on THP-1 macrophages

van de Velde, J., Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., Stavrakaki, I., Sonnenberg, A. S. M., Bakker, J. & Schots, A., 2015, In : Journal of the Science of Food and Agriculture. 95, 2, p. 344-350

Research output: Contribution to journalArticleAcademicpeer-review

Agaricales
mushrooms
macrophages
Molecular Weight
Macrophages

Engineering plants for the expression of helminth glycoproteins with their native N-glycan structures

Wilbers, R. H. P., Westerhof, L. B., Everts, B., van Noort, K., van Raaij, D. R., Nguyen, D., Yazdanbakhsh, M., Hokke, C. H. & Schots, A., 2015.

Research output: Contribution to conferencePosterProfessional

Helminths
Polysaccharides
Schistosoma mansoni
Glycoproteins
Helminth Proteins
2014
49 Citations (Scopus)

Apoplastic Venom Allergen-like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., Diaz Granados Muñoz, A., van Schaik, C. C., Helder, J., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014, In : PLoS Pathogens. 10, 12, 18 p., e1004569.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Plant Immunity
Venoms
Cell Surface Receptors
Innate Immunity
Allergens

Biological activity of human interleukin-22 expressed in Nicotiana benthamiana is independent of its N-glycosylation

Wilbers, R. H. P., Westerhof, L. B., Reuter, L. J., Castilho, A., van Raaij, D. R., Smant, G., Bakker, J. & Schots, A., 2014, Proceedings of The First Conference of the International Society for Plant Molecular Farming. p. 76-76

Research output: Chapter in Book/Report/Conference proceedingAbstract

Glycosylation
Human Activities
Tobacco
Cytokines
Polysaccharides

Expression of Schistosome-derived Omega-1 with diantennary glycans carrying Lewis X motifs in Nicotiana benthamiana plants

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., Capuder, E., van der Schuren, A., Nguyen, D., Hussaarts, L., Driessen, N., Hokke, C., Yazdanbakhsh, M., Bosch, D. & Schots, A., 2014, Proceedings of The First Conference of the International Society for Plant Molecular Farming. p. 22-22

Research output: Chapter in Book/Report/Conference proceedingAbstract

Schistosoma
Nicotiana benthamiana
polysaccharides
helminths
ribonucleases

Expression of Schistosome-derived Omega-1 with diantennary N-glycans carrying Lewis X motifs in Nicotiana benthamiana plants

Wilbers, R. H. P., Westerhof, L. B., van Raaij, D. R., Capuder, E., van der Schuren, A., Nguyen, D., Hussaarts, L., Driessen, N., Hokke, C. H., Yazdanbakhsh, M., Bosch, D. & Schots, A., 2014, Proceedings of Molecular and Cellular Biology of Helminths VIII. p. 66-66

Research output: Chapter in Book/Report/Conference proceedingAbstract

Tobacco
Polysaccharides
Helminths
Glycoproteins
Th2 Cells
14 Citations (Scopus)

Monomeric IgA can be produced in planta as efficient as IgG, yet receives different N-glycans

Westerhof, L. B., Wilbers, R. H. P., van Raaij, D. R., Nguyen, D., Goverse, A., Henquet, M. G. L., Hokke, C. H., Bosch, D., Bakker, J. & Schots, A., 2014, In : Plant Biotechnology Journal. 12, 9, p. 1333-1342

Research output: Contribution to journalArticleAcademicpeer-review

Plantae
Immunoglobulin A
Polysaccharides
polysaccharides
Immunoglobulin G

Secreted venom allergen-like proteins of plant-parasitic nematodes modulate defence responses in host plants

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Overmars, H. A., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2014, Proceedings of the 6th International Congress of Nematology, 4-9 May 2014, Cape Town, South Africa. p. 72-72

Research output: Chapter in Book/Report/Conference proceedingAbstract

venoms
plant parasitic nematodes
allergens
host plants
Globodera rostochiensis
venoms
plant parasitic nematodes
allergens
Globodera rostochiensis
plant response
2013
70 Citations (Scopus)

N-Glycosylation of Plant-produced Recombinant Proteins

Bosch, H. J., Castilho, A., Loos, A., Schots, A. & Steinkeller, H., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5503-5512

Research output: Contribution to journalArticleAcademicpeer-review

Glycosylation
Recombinant Proteins
Polysaccharides
Aptitude
Post Translational Protein Processing

Secreted venom allergen-like proteins of plant-parasitic nematodes modulate defence responses in host plants

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Overmars, H. A., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2013, Proceedings of 1st Annual Meeting, COST FA 1208, 09-11 October 2013, Birnam, Scotland. p. 32-32

Research output: Chapter in Book/Report/Conference proceedingAbstract

venoms
plant parasitic nematodes
allergens
host plants
Globodera rostochiensis

Venom allergen-like proteins secreted by plant-parasitic nematodes modulate defense responses mediated by extracellular innate immune receptors

Lozano Torres, J. L., Wilbers, R. H. P., Warmerdam, S., Finkers-Tomczak, A. M., van Schaik, C. C., Bakker, J., Goverse, A., Schots, A. & Smant, G., 2013, Proceedings of 1st Annual Meeting, COST FA 1208, 09-11 October 2013, Birnam, Scotland. p. 46-46

Research output: Chapter in Book/Report/Conference proceedingAbstract

venoms
plant parasitic nematodes
allergens
Globodera rostochiensis
proteins
2012
13 Citations (Scopus)

3D Domain Swapping Causes Extensive Multimerisation of Human Interleukin-10 When Expressed In Planta

Westerhof, L. B., Wilbers, R. H. P., Roosien, J., van de Velde, J., Goverse, A., Bakker, J. & Schots, A., 2012, In : PLoS ONE. 7, 10, 10 p., e46460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
interleukin-10
Plantae
Interleukin-10
Proteins
cytokines

A nematode venom allergen/ASP-like protein is required for plant-parasitism and induces a hypersensitive response through an extracellular leucine-rich repeat receptor

Lozano Torres, J. L., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, Proceedings of the Molecular and cellular biology of helminth parasites VII, 02- 09 September 2012, Hydra, Greece. p. 31-31

Research output: Chapter in Book/Report/Conference proceedingAbstract

venoms
hypersensitive response
allergens
leucine
parasitism

Dual Cf-2-mediated disease resistance in tomato requires a common virulence target of a fungus and a nematode

Lozano Torres, J. L., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A. M., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, Immunomodulation by plant-associated organisms, Fallen Leaf Lake, California, USA, 16-19 September 2012. Fallen Leaf Lake, California, USA, p. 68-68

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access
disease resistance
virulence
Nematoda
tomatoes
Solanum pimpinellifolium
136 Citations (Scopus)

Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode

Lozano, J., Wilbers, R. H. P., Gawronski, P., Boshoven, J. C., Finkers-Tomczak, A. M., Cordewener, J. H. G., America, A. H. P., Overmars, H. A., van t Klooster, J. W., Baranowski, L., Sobczak, M., Ilyas, M., van der Hoorn, R. A. L., Schots, A., de Wit, P. J. G. M., Bakker, J., Goverse, A. & Smant, G., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10119-10124

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
disease resistance
virulence
Nematoda
tomatoes
Solanum pimpinellifolium

Resolving 3D-domain swapping of human IL-10 prevents extensive multimerisation and increases yield

Westerhof, L. B., Wilbers, R. H. P., Roosien, J., Bakker, J. & Schots, A., 2012, Molecular farming: plants as production platform for high value proteins. Warsaw, p. 27-27

Research output: Chapter in Book/Report/Conference proceedingAbstract

Interleukin-10
Proteins
Cytokines
Dimerization
Glycosylation
2011

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Wilbers, R. H. P., Westerhof, L. B. & Schots, A., 2011.

Research output: Contribution to conferencePosterProfessional

Bananen met een aidsvaccin?

Bosch, H. J. & Schots, A., 2011, NIBI-conferentie : Kunnen we het maken?. Lunteren: NIBI, p. 49-49

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

Fungal polysaccharides recognized by animal immune cells differentially induce Th17 and Th1 responses

van de Velde, J., Oostindie, S., Peters, R. & Schots, A., 2011, Proceedings of the Autumn School 'Host-Microbe Interactomics, Wageningen, the Netherlands, 01-11-2011. Wageningen: PhD Autumn School, p. 19-19

Research output: Chapter in Book/Report/Conference proceedingAbstract

2010

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Westerhof, L. B., Wilbers, R. H. P. & Schots, A., 2010.

Research output: Contribution to conferenceAbstractAcademic

Open Access

Aggregation as a bottleneck for IL-10 production in Nicotiana benthamiana

Wilbers, R. H. P., Westerhof, L. B. & Schots, A., 2010.

Research output: Contribution to conferencePosterProfessional

Aggregation as a bottleneck for interleukin-10 production in Nicotiana benthamiana

Westerhof, L. B., Wilbers, R. H. P. & Schots, A., 2010.

Research output: Contribution to conferenceAbstractAcademic

Open Access