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Research Output 2005 2020

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Article
2020

Towards harmonization of test methods for in vitro hepatic clearance studies

Louisse, J., Alewijn, M., Peijnenburg, A. A. C. M., Cnubben, N. H. P., Heringa, M. B., Coecke, S. & Punt, A., Mar 2020, In : Toxicology in Vitro. 63, 1 p., 104722.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Rats
Liver
Hepatocytes
Regression analysis
Culture Media
2019
11 Citations (Scopus)

Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making

Paini, A., Leonard, J. A., Joossens, E., Bessems, J. G. M., Desalegn, A., Dorne, J. L., Gosling, J. P., Heringa, M. B., Klaric, M., Kliment, T., Kramer, N. I., Loizou, G., Louisse, J., Lumen, A., Madden, J. C., Patterson, E. A., Proença, S., Punt, A., Setzer, R. W., Suciu, N. & 4 others, Troutman, J., Yoon, M., Worth, A. & Tan, Y. M., Feb 2019, In : Computational Toxicology. 9, p. 61-72

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Decision Making
Decision making
Kinetics
Animals
Computer Simulation
2 Citations (Scopus)
Open Access
Extrapolation
polycarbonate
Monomers
Availability
Detoxification
2018
3 Citations (Scopus)

Data analyses and modelling for risk based monitoring of mycotoxins in animal feed

Ine van der Fels-Klerx, H. J., Adamse, P., Punt, A. & van Asselt, E. D., 1 Feb 2018, In : Toxins. 10, 2, 54.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mycotoxins
Zea mays
Animals
Aflatoxin B1
Monitoring
2 Citations (Scopus)
Open Access
Food safety
Food Safety
Expert Testimony
Kinetics
Animals
7 Citations (Scopus)

Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport

Abdelkhaliq, A., van der Zande, M., Punt, A., Helsdingen, R., Boeren, S., Vervoort, J. J. M., Rietjens, I. M. C. M. & Bouwmeester, H., 15 Sep 2018, In : Journal of Nanobiotechnology. 16, 1, 70.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanoparticles
Polystyrenes
Adhesion
Proteins
Surface chemistry

Implementation and verification of PBPK modelling codes of TCDD in rats and humans into Berkeley Madonna

Punt, A. & Ossendorp, B., 20 Nov 2018, In : EFSA Supporting Publications. 15, 11, 1374E.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
United States Environmental Protection Agency
Contracts
Polychlorinated Dibenzodioxins
2 Citations (Scopus)

Toxicokinetics in Risk Evaluations

Punt, A., 21 May 2018, In : Chemical Research in Toxicology. 31, 5, p. 285-286

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
In Vitro Techniques
Toxicokinetics
2017
4 Citations (Scopus)
Phenol
Toxicity
Kinetics
Dosimetry
Population
15 Citations (Scopus)
Open Access
Phenols
Toxicity
Kinetics
Dosimetry
Stem cells
6 Citations (Scopus)

In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans

Boonpawa, R., Spenkelink, A., Punt, A. & Rietjens, I. M. C. M., 2017, In : British Journal of Pharmacology. 174, 16, p. 2739-2757

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Phytoestrogens
Genistein
Computer Simulation
In Vitro Techniques
Benchmarking
10 Citations (Scopus)

Non-animal approaches for toxicokinetics in risk evaluations of food chemicals

Punt, A., Peijnenburg, A. A. C. M., Hoogenboom, R. L. A. P. & Bouwmeester, H., 2017, In : Altex. 34, 4, p. 501-514

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food
Pesticides
Animal Testing Alternatives
Toxicokinetics
Food Additives
6 Citations (Scopus)

Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans

Boonpawa, R., Spenkelink, B., Punt, A. & Rietjens, I., 2017, In : Molecular Nutrition & Food Research. 61, 8, 1600894.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Hesperidin
hesperidin
kinetics
metabolism
dosage
2016
3 Citations (Scopus)

Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling

Kiwamoto, R., Ploeg, D., Rietjens, I. M. C. M. & Punt, A., 1 Mar 2016, In : Toxicology in Vitro. 31, p. 114-125

Research output: Contribution to journalArticleAcademicpeer-review

DNA Adducts
Aldehydes
Computer Simulation
Food
Detoxification
8 Citations (Scopus)

Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling

Punt, A., Paini, A., Spenkelink, B., Scholz, G., Schilter, B., Van Bladeren, P. J. & Rietjens, I. M. C. M., 2016, In : Chemical Research in Toxicology. 29, 4, p. 659-668

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
DNA Adducts
Liver
Kinetics
Rodentia
20 Citations (Scopus)
nephrotoxicity
Cytotoxicity
Risk assessment
risk assessment
Toxicity
2015
6 Citations (Scopus)
Detoxification
Quantitative Structure-Activity Relationship
DNA Adducts
Aldehydes
Food
7 Citations (Scopus)

Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations

Al-Subeihi, A. A., Alhusainy, W., Kiwamoto, R., Spenkelink, A., van Bladeren, P. J., Rietjens, I. M. C. M. & Punt, A., 2015, In : Toxicology and Applied Pharmacology. 283, 2, p. 117-126

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
Kinetics
Uncertainty
Population
Population distribution
9 Citations (Scopus)

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Rietjens, I., Tyrakowska, B., van den Berg, S. J. P. L., Soffers, A. E. M. F. & Punt, A., 2015, In : Toxicology Research. 4, p. 23-35

Research output: Contribution to journalArticleAcademicpeer-review

Poisons
Metabolism
Risk assessment
Food
Bioassay
10 Citations (Scopus)
Open Access
Quercetin
Metabolites
Plasmas
Kinetics
Flavonoids
2014
11 Citations (Scopus)

A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats

Boonpawa, R., Spenkelink, A., Rietjens, I. & Punt, A., 2014, In : Biochemical Pharmacology. 89, 2, p. 287-299

Research output: Contribution to journalArticleAcademicpeer-review

Quercetin
Metabolites
Flavonoids
Rats
Plasmas
23 Citations (Scopus)

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models

Islam, M. A., Punt, A., Spenkelink, A., Murk, A. J., Leeuwen, F. X. R. & Rietjens, I., 2014, In : Molecular Nutrition & Food Research. 58, 3, p. 503-515

Research output: Contribution to journalArticleAcademicpeer-review

Isoflavones
Glucosides
isoflavones
glucosides
Glucosidases
11 Citations (Scopus)

Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo

Martati, E., Boonpawa, R., van den Berg, J. H. J., Paini, A., Spenkelink, A., Punt, A., Vervoort, J. J. M., van Bladeren, P. J. & Rietjens, I., 2014, In : Food and Chemical Toxicology. 66, p. 373-384

Research output: Contribution to journalArticleAcademicpeer-review

omega-Chloroacetophenone
Safrole
mace
safrole
DNA adducts
2013
10 Citations (Scopus)
Detoxification
DNA Adducts
Computer Simulation
Aldehydes
Nucleotides
34 Citations (Scopus)
Phenol
Toxicity
Rats
Risk assessment
Kinetics
14 Citations (Scopus)

Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the invivo predictive value

Punt, A., Brand, W., Murk, A. J., van Wezel, A. P., Schriks, M. & Heringa, M. B., 2013, In : Toxicology in Vitro. 27, 1, p. 44-51

Research output: Contribution to journalArticleAcademicpeer-review

Assays
Estrogens
Kinetics
Estrogen Receptor alpha
Genistein
12 Citations (Scopus)

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling.

Al-Subeihi, A. A., Alhusainy, W., Paini, A., Punt, A., Vervoort, J., van Bladeren, P. J. & Rietjens, I. M. C. M., 2013, In : Food and Chemical Toxicology. 59, p. 564-571

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
herbs
DNA adducts
kinetics
basil
16 Citations (Scopus)

In vivo validation and physiologically based biokinetic modeling of the inhibition of SULT-mediated estragole DNA adduct formation in the liver of male Sprague-Dawley rats by the basil flavonoid nevadensin

Alhusainy, W., Paini, A., van den Berg, J. H. J., Punt, A., Scholz, G., Schilter, B., van Bladeren, P. J., Taylor, S., Adams, T. B. & Rietjens, I., 2013, In : Molecular Nutrition & Food Research. 57, 11, p. 1969-1978

Research output: Contribution to journalArticleAcademicpeer-review

Ocimum basilicum
methyl chavicol
sulfotransferases
DNA adducts
Sulfotransferases
2012
10 Citations (Scopus)

A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in rat

Kiwamoto, R., Rietjens, I. & Punt, A., 2012, In : Chemical Research in Toxicology. 25, 12, p. 2630-2641

Research output: Contribution to journalArticleAcademicpeer-review

Detoxification
DNA Adducts
Computer Simulation
Rats
Aldehydes
18 Citations (Scopus)

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling

Paini, A., Punt, A., Scholz, G., Gremaud, E., Spenkelink, A., Alink, G. M., Schilter, B., van Bladeren, P. J. & Rietjens, I., 2012, In : Mutagenesis. 27, 6, p. 653-663

Research output: Contribution to journalArticleAcademicpeer-review

DNA Adducts
Liver
Rats
Glucuronides
Kidney
16 Citations (Scopus)

Matrix Modulation of the Bioactivation of Estragole by Constituents of Different Alkenylbenzene-containing Herbs and Spices and Physiologically Based Biokinetic Modeling of Possible In Vivo Effects

Al-Husainy, W. A. A. M., van den Berg, S. J. P. L., Paini, A., Campana, A., Asselman, M., Spenkelink, A., Punt, A., Scholz, G., Schilter, B., Adams, T. B., van Bladeren, P. J. & Rietjens, I., 2012, In : Toxicological sciences. 129, 1, p. 174-187

Research output: Contribution to journalArticleAcademicpeer-review

Spices
Flavonoids
Modulation
Sulfotransferases
DNA Adducts
18 Citations (Scopus)

Physiologically Based Biokinetic (PBBK) Modeling of Safrole Bioactivation and Detoxification in Humans as Compared With Rats

Martati, E., Boersma, M. G., Spenkelink, A., Khadka, D. B., van Bladeren, P. J., Rietjens, I. & Punt, A., 2012, In : Toxicological sciences. 128, 2, p. 301-316

Research output: Contribution to journalArticleAcademicpeer-review

Safrole
Detoxification
Metabolites
Rats
Liver
25 Citations (Scopus)

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat

Al-Subeihi, A. A., Spenkelink, A., Punt, A., Boersma, M. G., van Bladeren, P. J. & Rietjens, I., 2012, In : Toxicology and Applied Pharmacology. 260, 3, p. 271-284

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
Detoxification
Rats
Liver
Kinetics
16 Citations (Scopus)

Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.

van den Berg, S. J., Punt, A., Soffers, A. E. M. F., Vervoort, J. J. M., Ngeleja, S., Spenkelink, B. & Rietjens, I. M. C. M., 2012, In : Chemical Research in Toxicology. 25, 11, p. 2352-2367

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
Risk assessment
Rats
Metabolites
Kinetics
13 Citations (Scopus)
Poisons
Phenols
Embryonic Stem Cells
Stem cells
Cell culture
2011
28 Citations (Scopus)

Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice

Punt, A., Schiffelers, M. J. W. A., Horbach, J., van de Sandt, J. J. M., Groothuis, G. M. M., Rietjens, I. & Blaauboer, B. J., 2011, In : Regulatory Toxicology and Pharmacology. 61, 1, p. 105-114

Research output: Contribution to journalArticleAcademicpeer-review

Risk assessment
Animals
Kinetics
Testing
Research
20 Citations (Scopus)

Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats

Martati, E., Boersma, M. G., Spenkelink, A., Khadka, D. B., Punt, A., Vervoort, J. J. M., van Bladeren, P. J. & Rietjens, I., 2011, In : Chemical Research in Toxicology. 24, 6, p. 818-834

Research output: Contribution to journalArticleAcademicpeer-review

Safrole
Detoxification
Rats
Metabolites
methyleugenol
27 Citations (Scopus)

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat

Al-Subeihi, A. A., Spenkelink, A., Rachmawati, N., Boersma, M. G., Punt, A., Vervoort, J. J. M., van Bladeren, P. J. & Rietjens, I. M. C. M., 2011, In : Toxicology in Vitro. 25, 1, p. 267-285

Research output: Contribution to journalArticleAcademicpeer-review

methyleugenol
Detoxification
Rats
Metabolites
Liver
33 Citations (Scopus)

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research

Rietjens, I., Louisse, J. & Punt, A., 2011, In : Molecular Nutrition & Food Research. 55, 6, p. 941-956

Research output: Contribution to journalArticleAcademicpeer-review

nutrition research
food research
kinetics
Food
Research
2010
44 Citations (Scopus)

A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes

Paini, A., Punt, A., Viton, F., Scholz, G., Delatour, T., Marin-Kuan, M., Schilter, B., van Bladeren, P. J. & Rietjens, I., 2010, In : Toxicology and Applied Pharmacology. 245, 1, p. 57-66

Research output: Contribution to journalArticleAcademicpeer-review

DNA Adducts
Liver
Rats
Hepatocytes
Kinetics
17 Citations (Scopus)

Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic (PBBK) modeling

Punt, A., Jeurissen, S. M. F., Boersma, M. G., Delatour, T., Scholz, G., Schilter, B., van Bladeren, P. J. & Rietjens, I., 2010, In : Toxicological sciences. 113, 2, p. 337-348

Research output: Contribution to journalArticleAcademicpeer-review

Liver
Oxidation
Metabolites
Uncertainty
Area Under Curve
35 Citations (Scopus)

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

Al-Husainy, W. A. A. M., Paini, A., Punt, A., Louisse, J., Spenkelink, B., Vervoort, J. J. M., Delatour, T., Scholz, G., Schilter, B., Adams, T. B., van Bladeren, P. J. & Rietjens, I., 2010, In : Toxicology and Applied Pharmacology. 245, 2, p. 179-190

Research output: Contribution to journalArticleAcademicpeer-review

Physiology
Sulfotransferases
Ocimum basilicum
Rats
Detoxification
30 Citations (Scopus)

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: Implications for risk assessment

Rietjens, I., Punt, A., Schilter, B., Scholz, G., Delatour, T. & van Bladeren, P. J., 2010, In : Molecular Nutrition & Food Research. 54, 2, p. 195-207

Research output: Contribution to journalArticleAcademicpeer-review

methyl chavicol
coumarin
Computer Simulation
risk assessment
Chemical Safety
2009
53 Citations (Scopus)

Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in huyman as compared to male rat

Punt, A., Paini, A., Freidig, A. P., Delatour, T., Scholz, G., Schilter, B., van Bladeren, P. J. & Rietjens, I., 2009, In : Toxicological sciences. 110, 2, p. 255-269

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Detoxification
Rats
Metabolites
Kinetics
Liver
2008
54 Citations (Scopus)

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

Punt, A., Freidig, A., Delatour, T., Scholz, G., Schilter, B., van Bladeren, P. J. & Rietjens, I. M. C. M., 2008, In : Toxicology and Applied Pharmacology. 231, 2, p. 248-259

Research output: Contribution to journalArticleAcademicpeer-review

Detoxification
Rats
Metabolites
Metabolic Networks and Pathways
Glucuronides
39 Citations (Scopus)
Ocimum basilicum
sulfotransferases
DNA adducts
Sulfotransferases
basil
26 Citations (Scopus)
Poisons
Metabolites
Liver
Rats
Hydroxylation
24 Citations (Scopus)

Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits

de Waard, W. J., Aarts, J. M. M. J. G., Peijnenburg, A. A. C. M., Baykus, H., Talsma, E. F., Punt, A., de Kok, T. M. C. M., van Schooten, F. J. & Hoogenboom, L. A. P., 2008, In : Toxicology in Vitro. 22, p. 396-410

Research output: Contribution to journalArticleAcademicpeer-review

Citrus fruits
Aryl Hydrocarbon Receptors
Citrus
Benzo(a)pyrene
Vegetables
2007
48 Citations (Scopus)

Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes

Jeurissen, S. M. F., Punt, A., Boersma, M. G., Bogaards, J. J. P., Fiamegos, Y. C., Schilter, B., van Bladeren, P. J., Cnubben, N. H. P. & Rietjens, I. M. C. M., 2007, In : Chemical Research in Toxicology. 20, 5, p. 798-806

Research output: Contribution to journalArticleAcademicpeer-review

Cytochrome P-450 Enzyme System
methyleugenol
Hydroxylation
Safrole
Liver
42 Citations (Scopus)
Sulfotransferases
Sulfonation
Deoxyguanosine
Tandem Mass Spectrometry
Carcinogens