19962021

Research output per year

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Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries

Munk, P., Knudsen, B. E., Lukjacenko, O., Duarte, A. S. R., Van Gompel, L., Luiken, R. E. C., Smit, L. A. M., Schmitt, H., Garcia, A. D., Hansen, R. B., Petersen, T. N., Bossers, A., Ruppé, E., Graveland, H., van Essen, A., Gonzalez-Zorn, B., Moyano, G., Sanders, P., Chauvin, C., David, J. & 20 others, Battisti, A., Caprioli, A., Dewulf, J., Blaha, T., Wadepohl, K., Brandt, M., Wasyl, D., Skarzyńska, M., Zajac, M., Daskalov, H., Saatkamp, H. W., Stärk, K. D. C., Lund, O., Hald, T., Pamp, S. J., Vigre, H., Heederik, D., Wagenaar, J. A., Mevius, D. & Aarestrup, F. M., 23 Jul 2018, In : Nature Microbiology. 3, 8, p. 898-908

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Applicability of three anti-PrP peptide sera including staining of tonsils and brainstem of sheep with scrapie

Garssen, G. J., van Keulen, L. J. M., Farquhar, C. F., Smits, M. A., Jacobs, J. G., Bossers, A., Meloen, R. H. & Langeveld, J. P. M., 2000, In : Microscopy Research and Technique. 50, 1, p. 32-39

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries

Sep 2019, In : The Journal of antimicrobial chemotherapy. 74, 9, p. 2596-2604 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Caprine prion genen polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom.

Goldmann, W., Ryan, K., Stewart, P., Parnham, D., Xicohtencatl, R., Fernandez, N., Saunders, G., Windl, O., Gonzalez, L. & Bossers, A., 2011, In : Veterinary Research. 42, 8 p., 110.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
45 Citations (Scopus)

Cell-Free Propagation of Coxiella burnetii Does Not Affect Its Relative Virulence

Kuley, R., Smith, H. E., Frangoulidis, D., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : PLoS ONE. 10, 3, 16 p., e0121661.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Characterization of epidemic IncI1-Iγ plasmids harboring ambler class A and C genes in Escherichia coli and Salmonella enterica from animals and humans

Smith, H., Bossers, A., Harders, F., Wu, G., Woodford, N., Schwarz, S., Guerra, B., Rodríguez, I., Van Essen-Zandbergen, A., Brouwer, M. & Mevius, D., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5357-5365

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
27 Citations (Scopus)

Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains

Nonno, R., Marina Moreno, A., Espinosa, J. C., Fast, C., van Keulen, L. J. M., Spiropoulos, J., Lantier, I., Andrèoletti, O., Pirisinu, L., Di Bari, M. A., Aguilar-Calvo, P., Sklaviadis, T., Papasavva-Stylianou, P., Acutis, P. L., Acin, C., Bossers, A., Jacobs, J. G., Vaccari, G., D'Agostino, C., Chiappini, B. & 5 others, Lantier, F., Groschup, M. H., Agrimi, U., Torres, J. M. & Langeveld, J. P. M., 8 Jan 2020, In : Scientific Reports. 10, 1, 19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulation of low pathogenic avian influenza (LPAI) viruses in wild birds and poultry in the Netherlands, 2006-2016

Bergervoet, S. A., Pritz-Verschuren, S. B. E., Gonzales, J. L., Bossers, A., Poen, M. J., Dutta, J., Khan, Z., Kriti, D., van Bakel, H., Bouwstra, R., Fouchier, R. A. M. & Beerens, N., 23 Sep 2019, In : Scientific Reports. 9, 1, 1 p., 13681 .

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge

van Rijn, P. A., Bossers, A., Wensvoort, G. & Moormann, R. J. M., 1996, In : Journal of General Virology. 77, p. 2737-2745

Research output: Contribution to journalArticleAcademicpeer-review

119 Citations (Scopus)

Clinical microbiology of Coxiella burnetii and relevant aspects for the diagnosis and control of the zoonotic disease Q fever

Roest, H. I. J., Bossers, A., van Zijderveld, F. G. & Rebel, J. M. J., 2013, In : Veterinary Quarterly. 33, 3, p. 148-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Comparative genomic analysis of twelve Streptococcus suis (pro)phages

Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genomics. 101, 6, p. 336-344

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

Complete genome sequence and taxonomic position of anguillid herpesvirus 1

van Beurden, S. J., Bossers, A., Voorbergen-Laarman, H. A., Haenen, O. L. M., Peters, S. A., Abma-Henkens, M. H. C., Peeters, B. P. H., Rottier, P. J. M. & Engelsma, M. Y., 2010, In : Journal of General Virology. 91, 4, p. 880-887

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
51 Citations (Scopus)

Complete Genome Sequence of the Streptococcus suis Temperate Bacteriophage varphiNJ2

Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genome Announcements. 1, 1, e00008-12.

Research output: Contribution to journalArticleAcademicpeer-review

Complete genome sequences of Incl1 Plasmids carrying extended-spectrum B-Lactamase genes

Brouwer, M. S. M., Bossers, A., Harders, F., van Essen-Zandbergen, A., Mevius, D. J. & Smith, H. E., 2014, In : Genome Announcements. 2, 4, e00859-14.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie

Jacobs, J. G., Sauer, M., van Keulen, L. J. M., Tang, Y., Bossers, A. & Langeveld, J. P. M., 2011, In : Journal of General Virology. 92, 1, p. 222-232 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein

Thuring, C. M. A., Erkens, J. H. F., Jacobs, J. G., Bossers, A., van Keulen, L. J. M., Garssen, G. J., van Zijderveld, F. G., Ryder, S. J., Groschup, M. H., Sweeney, T. & Langeveld, J. P. M., 2004, In : Journal of Clinical Microbiology. 42, 3, p. 972-980

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
108 Citations (Scopus)

Early life microbial colonization of the gut and intestinal development differ between genetically divergent broiler lines

Schokker, D., Veninga, G., Vastenhouw, S. A., Bossers, A., de Bree, F. M., Kaal-Lansbergen, L. M. T. E., Rebel, J. M. J. & Smits, M. A., 2015, In : BMC Genomics. 16, 418.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
40 Citations (Scopus)

Effect of Q211 and K222 PRNP polymorphic variants in the susceptibility of goats to oral infections with Goat Bovine Spongiform Encephalopathy

Aguilar-Calvo, P., Fast, C., Tauscher, K., Espinosa, J. C., Groschup, M. H., Muhammad, N., Goldmann, W., Langeveld, J. P. M., Bossers, A. & Andreoletti, O., 2015, In : The Journal of Infectious Diseases. 212, 4, p. 664-672

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversions studies.

Priem, J., Langeveld, J. P. M., van Keulen, L. J. M., van Zijderveld, F. G., Andreoletti, O. & Bossers, A., 2014, In : Journal of Virology. 88, 5, p. 2903-2912

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Enzymatic degradation of prion protein in brain stem from infected cattle and sheep

Langeveld, J. P. M., Wang, J. J., van de Wiel, D. F. M., Shih, G. C., Garssen, G. J., Bossers, A. & Shih, J. C. H., 2003, In : The Journal of Infectious Diseases. 188, 11, p. 1782-1789

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
115 Citations (Scopus)

Eradicating BSE in goats

Langeveld, J. P. M. & Bossers, A., 2012, In : International Innovation. p. 100-102

Research output: Contribution to journalArticleProfessional

Open Access

Eradication of scrapie with selective breeding: are we nearly there?

Melchior, M. B., Windig, J. J., Hagenaars, T. H. J., Bossers, A., Davidse, A. & van Zijderveld, F. G., 2010, In : BMC Veterinary Research. 6, 9 p., 24.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats

Meloni, D., Bozzetta, E., Langeveld, J. P. M., Groschup, M. H., Goldmann, W., Andrèoletti, O., Lantier, I., Van Keulen, L., Bossers, A., Pitardi, D., Nonno, R., Sklaviadis, T., Ingravalle, F., Peletto, S., Colussi, S. & Acutis, P. L., 2017, In : Journal of Veterinary Diagnostic Investigation. 29, 2, p. 232-236

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
Open Access
3 Citations (Scopus)

First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937

Kuley, R., Smith, H. E., Janse, I., Harders, F. L., Baas, F., Schijlen, E., Nabuurs-Fransen, M. H., Smits, M. A., Roest, H. I. J. & Bossers, A., 2016, In : Genome Announcements. 4, 2, 2 p., e00245-16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Four independent molecular prion protein parameters for discriminating new cases of C, L, and H BSE in cattle.

Langeveld, J. P. M., Erkens, J. H. F., Rammel, I., Jacobs, J. G., Davidse, A., van Zijderveld, F. G., Bossers, A. & Schildorfer, H., 2011, In : Journal of Clinical Microbiology. 49, 8, p. 3026-3028

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods

Langeveld, J. P. M., Pirisinu, L., Jacobs, J. G., Mazza, M., Lantier, I., Simon, S., Andrèoletti, O., Acin, C., Esposito, E., Fast, C., Groschup, M. H., Goldmann, W., Spiropoulos, J., Sklaviadis, T., Lantier, F., Ekateriniadou, L. V., Papasavva-Stylianou, P., van Keulen, L. J. M., Acutis, P. L., Agrimi, U. & 2 others, Bossers, A. & Nonno, R., 25 Nov 2019, In : Veterinary Research. 50, 97.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Full-genome sequence of influenza A(H5N8) virus in poultry linked to sequences of strains from Asia, the Netherlands, 2014

Bouwstra, R., Heutink, R., Bossers, A., Harders, F., Koch, G. & Elbers, A., 2015, In : Emerging Infectious Diseases. 21, 5, p. 872-874

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
32 Citations (Scopus)

Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Lyahyai, J., Zaragoza, P., Pumarola, M., Badiola, J. J., Bossers, A. & Bolea, R., 2011, In : PLoS ONE. 6, 5, 12 p., e19909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Hedman, C., Mediano, D. R., Monzón, M., Bossers, A. & Badiola, J. J., 2014, In : BMC Genomics. 15, 17 p., 59.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus

Niedermeyer, S., Eiden, M., Toumazos, P., Langeveld, J. & Bossers, A., 2016, In : Veterinary Research. 47, 14 p., 99.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Genetic characterization of an atypical Schmallenberg virus isolated from the brain of a malformed lamb

Hulst, M. M., Kortekaas, J. A., van der Hakze-van der Honing, R. W., Vastenhouw, S. A., Cornelissen, J. B. W. J., van Maanen, K., Bossers, A., Harders, F. L., Stockhofe, N. & van der Poel, W. H. M., 2013, In : Virus Genes. 47, 3, p. 505-514

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Genetic relationship between poultry and wild bird viruses during the highly pathogenic avian influenza H5N6 epidemic in the Netherlands, 2017–2018

Beerens, N., Heutink, R., Pritz-Verschuren, S., Germeraad, E. A., Bergervoet, S. A., Harders, F., Bossers, A. & Koch, G., May 2019, In : Transboundary and Emerging Diseases. 66, 3, p. 1370-1378

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy

Acutis, P. L., Colussi, S., Santagada, G., Laurenza, C., Maniaci, M. G., Riina, M. V., Peletto, S., Goldmann, W., Bossers, A., Caramelli, M., Cristoferi, I., Maione, S., Sacchi, P. & Rasero, R., 2008, In : Journal of Applied Microbiology. 104, 6, p. 1782-1789

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Genome plasticity and polymorphisms in critical genes correlate with increased virulence of Dutch outbreak-related Coxiella burnetii strains

Kuley, R., Kuijt, E., Smits, M. A., Roest, H. I. J., Smith, H. E. & Bossers, A., 10 Aug 2017, In : Frontiers in Microbiology. 8, 1526.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Genomic and functional characterisation of IncX3 plasmids encoding bla SHV-12 in Escherichia coli from human and animal origin

Liakopoulos, A., Van Der Goot, J., Bossers, A., Betts, J., Brouwer, M. S. M., Kant, A., Smith, H., Ceccarelli, D. & Mevius, D., 1 Dec 2018, In : Scientific Reports. 8, 1, 7674.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Genomic and phylogenetic charaterization of Shuni virus

van Eeden, C., Harders, F., Kortekaas, J. A., Bossers, A. & Venter, M., 2014, In : Archives of Virology. 159, 11, p. 2883-2892

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Human Variant Creutzfeldt-Jakob disease and sheep scrapie PrP (res) detection using seeded conversion of recombinant prion protein.

Orrú, C. D., Wilham, J. M., Hughson, A. G., Raymond, L. D., McNally, K. L., Bossers, A., Ligios, C. & Caughey, B., 2009, In : Protein Engineering, Design & Selection. 22, 8, p. 515-521

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks

Acutis, P. L., Bossers, A., Priem, J., Riina, M. V., Peletto, S., Mazza, M., Casalone, C., Forloni, G., Ru, G. & Caramelli, M., 2006, In : Journal of General Virology. 87, p. 1029-1033

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
81 Citations (Scopus)

Immunolabelling of non-phosphorylated neurofilament indicates damage of spinal cord axons in TSE-infected goats

Nadeem, M., Spitzbarth, I., Haist, V., Rohn, K., Tauscher, K., Rohn, K., Bossers, A., Langeveld, J., Papasavva-Stylianou, P., Groschup, M. H., Baumgärtner, W., Gerhauser, I. & Fast, C., 2016, In : Veterinary Record. 178, 6, p. 141 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Incl shufflons: Assembly issues in the next-generation sequencing era

Brouwer, M. S., Tagg, K. A., Mevius, D. J., Iredell, J. R., Bossers, A., Smith, H. E. & Partridge, S. R., 2015, In : Plasmid. 80, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Incompatibility and phylogenetic relationship of I-complex plasmids

Rozwandowicz, M., Hordijk, J., Bossers, A., Zomer, A. L., Wagenaar, J. A., Mevius, D. J. & Brouwer, M. S. M., May 2020, In : Plasmid. 109, 102502.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vitro conversion of normal prion protein into pathologic isoforms

Bossers, A., Rigter, A., de Vries, R. & Smits, M. A., 2003, In : Clinics in Laboratory Medicine. 23, 1, p. 227-247

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Limited changes in the fecal microbiome composition of laying hens after oral inoculation with wild duck feces

Schreuder, J., Velkers, F. C., Bouwstra, R. J., Beerens, N., Stegeman, J. A., de Boer, W. F., Elbers, A. R. W., van Hooft, P., Feberwee, A., Bossers, A. & Jurburg, S. D., 2019, In : Poultry Science. 98, 12, p. 6542–6551

Research output: Contribution to journalArticleProfessional

Open Access
1 Citation (Scopus)

Low frequency of the scrapile resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed

Acutis, P. L., Sbaiz, L., Verburg, F. J., Riina, M. V., Ru, G., Moda, G., Caramelli, M. & Bossers, A., 2004, In : Journal of General Virology. 85, p. 3165-3172

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
40 Citations (Scopus)

Major differential gene regulation in Coxiella burnetii between in vivo and in vitro cultivation models

Kuley, R., de Vries, R., Smith, H. E., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : BMC Genomics. 16, 953.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Mapping functional prion-prion protein interaction sites using prion protein based peptide-arrays

Rigter, A., Priem, J., Timmers-Parohi, D., Langeveld, J. & Bossers, A., 2009, In : Methods in molecular biology. 570, 2, p. 257-271

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Mapping of possible prion protein self interaction domains using peptide arrays

Rigter, A., Langeveld, J. P. M., Timmers-Parohi, D., Jacobs, J. G., Moonen, P. L. J. M. & Bossers, A., 2007, In : BMC Biochemistry. 8, 14 p., 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their associaition with prion-related lesions.

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Serrano, C., Acín, C., Badiola, J. J., Bossers, A. & Bolea, R., 2012, In : BMC Genomics. 13, 399.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)