19962021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
1996

Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge

van Rijn, P. A., Bossers, A., Wensvoort, G. & Moormann, R. J. M., 1996, In : Journal of General Virology. 77, p. 2737-2745

Research output: Contribution to journalArticleAcademicpeer-review

119 Citations (Scopus)
1997

Molecular assessment of the potential transmissibilities of BSE and scrapie to humans

Raymond, G. J., Hope, J., Kocisko, D. A., Priola, S. A., Raymond, L. D., Bossers, A., Ironside, J., Will, R. G., Chen, S. G., Petersen, R. B., Gambetti, P., Rubenstei, R., Smits, M. A., Lansbury, P. T. & Caughey, B., 1997, In : Nature. 388, p. 285-288

Research output: Contribution to journalArticleAcademicpeer-review

218 Citations (Scopus)

Prion protein and scrapie susceptibility

Smits, M. A., Bossers, A. & Schreuder, B. E. C., 1997, In : Veterinary Quarterly. 19, 3, p. 101-105

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms

Bossers, A., Belt, P. B. G. M., Raymond, G. J., Caughey, B., de Vries, R. & Smits, M., 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 10, p. 4931-4936

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
150 Citations (Scopus)
1999

Prion diseases: susceptibility and transmissibility. In vivo and in vitro studies with sheep scrapie

Bossers, A., 1999, In : Curious.

Research output: Contribution to journalArticleProfessional

PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie

Bossers, A., Harders, F. L. & Smits, M. A., 1999, In : Archives of Virology. 144, p. 829-834

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)
2000

Applicability of three anti-PrP peptide sera including staining of tonsils and brainstem of sheep with scrapie

Garssen, G. J., van Keulen, L. J. M., Farquhar, C. F., Smits, M. A., Jacobs, J. G., Bossers, A., Meloen, R. H. & Langeveld, J. P. M., 2000, In : Microscopy Research and Technique. 50, 1, p. 32-39

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)
2003

Enzymatic degradation of prion protein in brain stem from infected cattle and sheep

Langeveld, J. P. M., Wang, J. J., van de Wiel, D. F. M., Shih, G. C., Garssen, G. J., Bossers, A. & Shih, J. C. H., 2003, In : The Journal of Infectious Diseases. 188, 11, p. 1782-1789

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
114 Citations (Scopus)

In vitro conversion of normal prion protein into pathologic isoforms

Bossers, A., Rigter, A., de Vries, R. & Smits, M. A., 2003, In : Clinics in Laboratory Medicine. 23, 1, p. 227-247

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2004

Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein

Thuring, C. M. A., Erkens, J. H. F., Jacobs, J. G., Bossers, A., van Keulen, L. J. M., Garssen, G. J., van Zijderveld, F. G., Ryder, S. J., Groschup, M. H., Sweeney, T. & Langeveld, J. P. M., 2004, In : Journal of Clinical Microbiology. 42, 3, p. 972-980

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
108 Citations (Scopus)

Low frequency of the scrapile resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed

Acutis, P. L., Sbaiz, L., Verburg, F. J., Riina, M. V., Ru, G., Moda, G., Caramelli, M. & Bossers, A., 2004, In : Journal of General Virology. 85, p. 3165-3172

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
40 Citations (Scopus)
2005
Open Access
16 Citations (Scopus)
2006

Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks

Acutis, P. L., Bossers, A., Priem, J., Riina, M. V., Peletto, S., Mazza, M., Casalone, C., Forloni, G., Ru, G. & Caramelli, M., 2006, In : Journal of General Virology. 87, p. 1029-1033

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
81 Citations (Scopus)

Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep

Langeveld, J. P. M., Jacobs, J. G., Erkens, J. H. F., Bossers, A., van Zijderveld, F. G. & van Keulen, L. J. M., 2006, In : BMC Veterinary Research. 2, 19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
90 Citations (Scopus)
2007

Mapping of possible prion protein self interaction domains using peptide arrays

Rigter, A., Langeveld, J. P. M., Timmers-Parohi, D., Jacobs, J. G., Moonen, P. L. J. M. & Bossers, A., 2007, In : BMC Biochemistry. 8, 14 p., 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

PrP genotypes in a pedigree flock of Santa Ines sheep

de Lima, A. C. B., Bossers, A., Souza, C. E. A., Oliveira, S. M. P. & Oliveira, D. M., 2007, In : Veterinary Record. 160, 10, p. 336-337

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein

Meade-White, K., Race, B., Trifilo, M., Bossers, A., Favara, C., Lacasse, R., Miller, M., Williams, E., Oldstone, M., Race, R. & Chesebro, B., 2007, In : Journal of Virology. 81, 9, p. 4533-4539

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
53 Citations (Scopus)
2008

Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy

Acutis, P. L., Colussi, S., Santagada, G., Laurenza, C., Maniaci, M. G., Riina, M. V., Peletto, S., Goldmann, W., Bossers, A., Caramelli, M., Cristoferi, I., Maione, S., Sacchi, P. & Rasero, R., 2008, In : Journal of Applied Microbiology. 104, 6, p. 1782-1789

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Pathogenesis of bovine spongiform encephalopathy in sheep

van Keulen, L. J. M., Vromans, M. E. W., Dolstra, C. H., Bossers, A. & van Zijderveld, F. G., 2008, In : Archives of Virology. 153, 3, p. 445-453

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
52 Citations (Scopus)

TSE pathogenesis in cattle and sheep

van Keulen, L. J. M., Bossers, A. & van Zijderveld, F. G., 2008, In : Veterinary Research. 39, 4, 12 p., 24.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
68 Citations (Scopus)
2009

Human Variant Creutzfeldt-Jakob disease and sheep scrapie PrP (res) detection using seeded conversion of recombinant prion protein.

Orrú, C. D., Wilham, J. M., Hughson, A. G., Raymond, L. D., McNally, K. L., Bossers, A., Ligios, C. & Caughey, B., 2009, In : Protein Engineering, Design & Selection. 22, 8, p. 515-521

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Mapping functional prion-prion protein interaction sites using prion protein based peptide-arrays

Rigter, A., Priem, J., Timmers-Parohi, D., Langeveld, J. & Bossers, A., 2009, In : Methods in molecular biology. 570, 2, p. 257-271

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Prion protein self-peptides modulate prion interactions and conversion

Rigter, A., Priem, J., Timmers-Parohi, D., Langeveld, J. P. M., van Zijderveld, F. G. & Bossers, A., 2009, In : BMC Biochemistry. 10, 16 p., 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology

Vaccari, G., Panagiotidis, C. H., Acin, C., Peletto, S., Barillet, F., Acutis, P., Bossers, A., Langeveld, J. P. M., van Keulen, L. J. M., Sklaviadis, T., Badiola, J. J., Andreoletti, O., Groschup, M. H., Agrimi, U., Foster, J. & Goldmann, W., 2009, In : Veterinary Research. 40, 5, p. 48 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
88 Citations (Scopus)
2010

Complete genome sequence and taxonomic position of anguillid herpesvirus 1

van Beurden, S. J., Bossers, A., Voorbergen-Laarman, H. A., Haenen, O. L. M., Peters, S. A., Abma-Henkens, M. H. C., Peeters, B. P. H., Rottier, P. J. M. & Engelsma, M. Y., 2010, In : Journal of General Virology. 91, 4, p. 880-887

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
51 Citations (Scopus)

Eradication of scrapie with selective breeding: are we nearly there?

Melchior, M. B., Windig, J. J., Hagenaars, T. H. J., Bossers, A., Davidse, A. & van Zijderveld, F. G., 2010, In : BMC Veterinary Research. 6, 9 p., 24.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Prion Protein Self Interactions; a gateway to novel therapeutic strategies?

Rigter, A., Langeveld, J. P. M., van Zijderveld, F. G. & Bossers, A., 2010, In : Vaccine. 28, 49, p. 7810-7823

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

Hagenaars, T. H. J., Melchior, M. B., Bossers, A., Davidse, A., Engel, B. & van Zijderveld, F. G., 2010, In : BMC Veterinary Research. 6, 25.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
35 Citations (Scopus)

Caprine prion genen polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom.

Goldmann, W., Ryan, K., Stewart, P., Parnham, D., Xicohtencatl, R., Fernandez, N., Saunders, G., Windl, O., Gonzalez, L. & Bossers, A., 2011, In : Veterinary Research. 42, 8 p., 110.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
45 Citations (Scopus)

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie

Jacobs, J. G., Sauer, M., van Keulen, L. J. M., Tang, Y., Bossers, A. & Langeveld, J. P. M., 2011, In : Journal of General Virology. 92, 1, p. 222-232 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Four independent molecular prion protein parameters for discriminating new cases of C, L, and H BSE in cattle.

Langeveld, J. P. M., Erkens, J. H. F., Rammel, I., Jacobs, J. G., Davidse, A., van Zijderveld, F. G., Bossers, A. & Schildorfer, H., 2011, In : Journal of Clinical Microbiology. 49, 8, p. 3026-3028

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Lyahyai, J., Zaragoza, P., Pumarola, M., Badiola, J. J., Bossers, A. & Bolea, R., 2011, In : PLoS ONE. 6, 5, 12 p., e19909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Prion protein self-interaction in prion disease therapy approaches

Rigter, A., Priem, J., Langeveld, J. P. M. & Bossers, A., 2011, In : Veterinary Quarterly. 31, 3, p. 115-128

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Proteinase K resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein

Jacobs, J. G., Bossers, A., Rezaei, H., Van Keulen, L., McCutcheon, S., Sklaviadis, T., Lantier, I., Berthon, P., Lantier, F., van Zijderveld, F. G. & Langeveld, J. P. M., 2011, In : Journal of Virology. 85, 23, p. 12537-12546

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)
2012

Eradicating BSE in goats

Langeveld, J. P. M. & Bossers, A., 2012, In : International Innovation. p. 100-102

Research output: Contribution to journalArticleProfessional

Open Access

Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their associaition with prion-related lesions.

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Serrano, C., Acín, C., Badiola, J. J., Bossers, A. & Bolea, R., 2012, In : BMC Genomics. 13, 399.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)
2013

Clinical microbiology of Coxiella burnetii and relevant aspects for the diagnosis and control of the zoonotic disease Q fever

Roest, H. I. J., Bossers, A., van Zijderveld, F. G. & Rebel, J. M. J., 2013, In : Veterinary Quarterly. 33, 3, p. 148-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Comparative genomic analysis of twelve Streptococcus suis (pro)phages

Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genomics. 101, 6, p. 336-344

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

Complete Genome Sequence of the Streptococcus suis Temperate Bacteriophage varphiNJ2

Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genome Announcements. 1, 1, e00008-12.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic characterization of an atypical Schmallenberg virus isolated from the brain of a malformed lamb

Hulst, M. M., Kortekaas, J. A., van der Hakze-van der Honing, R. W., Vastenhouw, S. A., Cornelissen, J. B. W. J., van Maanen, K., Bossers, A., Harders, F. L., Stockhofe, N. & van der Poel, W. H. M., 2013, In : Virus Genes. 47, 3, p. 505-514

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2014

Complete genome sequences of Incl1 Plasmids carrying extended-spectrum B-Lactamase genes

Brouwer, M. S. M., Bossers, A., Harders, F., van Essen-Zandbergen, A., Mevius, D. J. & Smith, H. E., 2014, In : Genome Announcements. 2, 4, e00859-14.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversions studies.

Priem, J., Langeveld, J. P. M., van Keulen, L. J. M., van Zijderveld, F. G., Andreoletti, O. & Bossers, A., 2014, In : Journal of Virology. 88, 5, p. 2903-2912

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

Filali, H., Martin-Burriel, I., Harders, F., Varona, L., Hedman, C., Mediano, D. R., Monzón, M., Bossers, A. & Badiola, J. J., 2014, In : BMC Genomics. 15, 17 p., 59.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Genomic and phylogenetic charaterization of Shuni virus

van Eeden, C., Harders, F., Kortekaas, J. A., Bossers, A. & Venter, M., 2014, In : Archives of Virology. 159, 11, p. 2883-2892

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Paramyxovirus-based producton of Rift Valley fever virus replicon particles

Wichgers Schreur, P. J., Oreshkova, N., Harders, F., Bossers, A., Moormann, R. J. M. & Kortekaas, J. A., 2014, In : Journal of General Virology. 95, 12, p. 2638-2648

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Role of the Goat K222-PrPC Polymorphic variant in Prion Infection Resistance

Aguilar-Calvo, P., Espinosa, J. C., Pintado, B., Gutiérrez-Adán, A., Alamilo, E., Miranda, A., Prieto, I., Bossers, A., Andreoletti, O. & Torres, J. M., 2014, In : Journal of Virology. 88, 5, p. 2670-2676

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie

Langeveld, J. P. M., Jacobs, J. G., Erkens, J. H. F., Baron, T., Andreoletti, O., Yokoyama, T., van Keulen, L. J. M., van Zijderveld, F. G., Davidse, A., Hope, J., Tang, Y. & Bossers, A., 2014, In : Prion. 8, 4, p. 296-305

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)
2015

Cell-Free Propagation of Coxiella burnetii Does Not Affect Its Relative Virulence

Kuley, R., Smith, H. E., Frangoulidis, D., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : PLoS ONE. 10, 3, 16 p., e0121661.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Characterization of epidemic IncI1-Iγ plasmids harboring ambler class A and C genes in Escherichia coli and Salmonella enterica from animals and humans

Smith, H., Bossers, A., Harders, F., Wu, G., Woodford, N., Schwarz, S., Guerra, B., Rodríguez, I., Van Essen-Zandbergen, A., Brouwer, M. & Mevius, D., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5357-5365

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
25 Citations (Scopus)