Research Output 1976 2020

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2020

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients

Rietjens, I. M. C. M., Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, P. F., Hecht, S. S., Rosol, T. J., Davidsen, J. M., Harman, C. L., Murray, I. J. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110949.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Myroxylon
Cinnamomum
Flavors
flavorings
Cassia

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, P. F., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Agathosma betulina
Anethum graveolens
Carum
Mints
caraway
2019

Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment

Gilbert Sandoval, I., Wesseling, S. & Rietjens, I. M. C. M., 15 Oct 2019, In : Toxicology Reports. 6, p. 1135-1142 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Aflatoxin B1
Mexico
Risk assessment
Zea mays
Needs Assessment
1 Citation (Scopus)

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

Behr, C., Slopianka, M., Haake, V., Strauss, V., Sperber, S., Kamp, H., Walk, T., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Jan 2019, In : Toxicology and Applied Pharmacology. 363, p. 79-87

Research output: Contribution to journalArticleAcademicpeer-review

Metabolome
Bile Acids and Salts
Feces
Rats
Anti-Bacterial Agents
1 Citation (Scopus)

Bioaccumulation of polycyclic aromatic hydrocarbons by Arctic and temperate benthic species

Szczybelski Ciordia, A. S., Diepens, N. J., van den Heuvel-Greve, M. J., van den Brink, N. W. & Koelmans, A. A., Apr 2019, In : Environmental Toxicology and Chemistry. 38, 4, p. 883-895

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biota
Bioaccumulation
Polycyclic Aromatic Hydrocarbons
bioaccumulation
PAH
2 Citations (Scopus)
Polycyclic Aromatic Hydrocarbons
Pyrene
Biomarkers
biotransformation
Polycyclic aromatic hydrocarbons

Biotransformation and bioactivation reactions – 2018 literature highlights

Khojasteh, S. C., Bumpus, N. N., Driscoll, J. P., Miller, G. P., Mitra, K., Rietjens, I. M. C. M. & Zhang, D., 6 Aug 2019, In : Drug Metabolism Reviews. 51, 2, p. 121-161

Research output: Contribution to journalArticleAcademicpeer-review

Biotransformation
Pharmaceutical Preparations
Drug Discovery
Computer Simulation
Toxicology
1 Citation (Scopus)

Bioturbation of Ag2S-NPs in soil columns by earthworms

Baccaro, M., Harrison, S., van den Berg, H., Sloot, L., Hermans, D., Cornelis, G., van Gestel, C. A. M. & van den Brink, N. W., Sep 2019, In : Environmental Pollution. 252, p. 155-162

Research output: Contribution to journalArticleAcademicpeer-review

Oligochaeta
Soil
Soils
Sewage
Rain
Macrophages
Cadmium
Mast Cells
Cells
Modulation
1 Citation (Scopus)

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Kramer, N. I., Hoffmans, Y., Wu, S., Thiel, A., Thatcher, N., Allen, T. E. H., Levorato, S., Traussnig, H., Schulte, S., Boobis, A., Rietjens, I. M. C. M. & Vinken, M., Aug 2019, In : Archives of Toxicology. 93, 8, p. 2115-2125

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food additives
Food Additives
Safety
Databases
Cardiovascular system

Digestion-on-a-chip: A continuous-flow modular microsystem recreating enzymatic digestion in the gastrointestinal tract

De Haan, P., Ianovska, M. A., Mathwig, K., Van Lieshout, G. A. A., Triantis, V., Bouwmeester, H. & Verpoorte, E., 5 Apr 2019, In : Lab on a Chip. 19, 9, p. 1599-1609 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microsystems
Nutrients
Gastrointestinal Tract
Digestion
Digestive system
Open Access
Liquid chromatography
Liquid Chromatography
Biological Availability
Mass spectrometry
Mass Spectrometry
1 Citation (Scopus)

Ecology and conservation of the endemic Bawean warty pig Sus verrucosus blouchi and Bawean deer Axis kuhlii

Rode-Margono, E. J., Khwaja, H., Rademaker, M. & Semiadi, G., 27 Mar 2019, In : Oryx.

Research output: Contribution to journalArticleAcademicpeer-review

Sus
pig
deer
ecology
swine

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)mediated gene expression in vitro

Hiben, M. G., De Haan, L., Spenkelink, B., Wesseling, S., Louisse, J., Vervoort, J. & Rietjens, I. M. C. M., 1 Apr 2019, In : PLoS ONE. 14, 4, e0215155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Maerua
glucobrassicin
Gene expression
Cytotoxicity
Fruits

Excreta emissions in progeny of low and high enteric methane yield selection line sheep fed pasture of different qualities

Jonker, A., MacLean, S., Woyimo Woju, C., Garcia Rendon Calzada, M., Yu, W., Molano, G., Hickey, S., Pinares-Patiño, C. S., McEwan, J. C., Janssen, P. H., Sandoval, E., Lewis, S. & Rowe, S., Nov 2019, In : Animal Feed Science and Technology. 257, 114289.

Research output: Contribution to journalArticleAcademicpeer-review

excreta
methane
pastures
dry matter intake
sheep
2 Citations (Scopus)

Facilitated delignification in CAD deficient transgenic poplar studied by confocal Raman spectroscopy imaging

Segmehl, J. S., Keplinger, T., Krasnobaev, A., Berg, J. K., Willa, C. & Burgert, I., 5 Jan 2019, In : Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 206, p. 177-184

Research output: Contribution to journalArticleAcademicpeer-review

Delignification
biomass
computer aided design
lignin
Raman spectroscopy
3 Citations (Scopus)

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Citrus
Flavors
flavorings
ingredients
flavor

Hatching failure and accumulation of organic pollutants through the terrestrial food web of a declining songbird in Western Europe

van Oosten, H. H., van den Burg, A. B., Arlt, D., Both, C., van den Brink, N. W., Chiu, S., Crump, D., Jeppsson, T., de Kroon, H., Traag, W. & Siepel, H., 10 Feb 2019, In : Science of the Total Environment. 650, p. 1547-1553

Research output: Contribution to journalArticleAcademicpeer-review

Dioxins
songbird
Organic pollutants
Birds
Nutrition
1 Citation (Scopus)

Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests

Gebrelibanos Hiben, M., Kamelia, L., de Haan, L., Spenkelink, B., Wesseling, S., Vervoort, J. & Rietjens, I. M. C. M., 15 Sep 2019, In : Journal of Ethnopharmacology. 241, 111978.

Research output: Contribution to journalArticleAcademicpeer-review

Aryl Hydrocarbon Receptors
Fruit
Zebrafish
Isothiocyanates
Estrogen Receptor alpha

Induction of EpRE-mediated gene expression by a series of mediterranean botanicals and their constituents

Papadi, G., Wesseling, S., Troganis, A. N., Vervoort, J. & Rietjens, I. M. C. M., 10 Aug 2019, In : Journal of Ethnopharmacology. 240, 13 p., 111940.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Frangula
Rhamnus
Gene Expression
Liquid Chromatography
Mass Spectrometry

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J., Rietjens, I. M. C. M. & Strikwold, M., 1 Oct 2019, In : Archives of Toxicology. 93, 10, p. 2943-2960 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Liver
Toxicity
Kinetics
Population
Pyrrolizidine Alkaloids
1 Citation (Scopus)
Open Access
Aryl Hydrocarbon Receptors
Polycyclic Aromatic Hydrocarbons
Petroleum
Toxicity
Dimethyl Sulfoxide
2 Citations (Scopus)

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Suparmi, S., Ginting, A. J., Mariyam, S., Wesseling, S. & Rietjens, I. M. C. M., 1 Mar 2019, In : Food and Chemical Toxicology. 125, p. 467-478

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
methyleugenol
Eugenol
Beverages
eugenol
Risk assessment
1 Citation (Scopus)

Novel approaches to derive points of departure for food chemical risk assessment

Levorato, S., Rietjens, I. M. C. M., Carmichael, P. L. & Hepburn, P. A., Jun 2019, In : Current Opinion in Food Science. 27, p. 139-144

Research output: Contribution to journalArticleAcademicpeer-review

chemical risk assessment
toxicogenomics
Food
in vivo studies
toxicity testing
1 Citation (Scopus)

Online and in situ analysis of organs-on-a-chip

Santbergen, M. J. C., van der Zande, M., Bouwmeester, H. & Nielen, M. W. F., 1 Jun 2019, In : TrAC - Trends in Analytical Chemistry. 115, p. 138-146 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell culture
Metabolism
Sugars
Culture Media
Salts
Open Access
Pyrrolizidine Alkaloids
Liver
Dosimetry
Rats
Kinetics
3 Citations (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Organic Anion Transporters
Proximal Kidney Tubule
Anions
Indican
Kidney

Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic

Prinsloo, G., Steffens, F., Vervoort, J. & Rietjens, I. M. C. M., Dec 2019, In : Critical Reviews in Toxicology. p. 1-13

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
exposure scenario
Pyrrolizidine Alkaloids
herbal tea
pyrrolizidine alkaloids
Herbal Medicine
1 Citation (Scopus)
Open Access
Pyrrolizidine Alkaloids
pyrrolizidine alkaloids
Risk assessment
pharmacokinetics
risk assessment
1 Citation (Scopus)

Strategies for robust and accurate experimental approaches to quantify nanomaterial bioaccumulation across a broad range of organisms

Petersen, E. J., Mortimer, M., Burgess, R. M., Handy, R., Hanna, S., Ho, K. T., Johnson, M., Loureiro, S., Selck, H., Scott-Fordsmand, J. J., Spurgeon, D., Unrine, J., Van Den Brink, N. W., Wang, Y., White, J. & Holden, P., Jun 2019, In : Environmental Science: Nano. 6, 6, p. 1619-1656 38 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bioaccumulation
Nanostructured materials
bioaccumulation
analytical method
organism
3 Citations (Scopus)

The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy

Adam, A. H. B., Zhang, M., de Haan, L. H. J., van Ravenzwaay, B., Louisse, J. & Rietjens, I. M. C. M., Jul 2019, In : Archives of Toxicology. 93, 7, p. 2021-2033

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diethylstilbestrol
Toxicity
Rats
Testing
Estrogen Receptor alpha
Open Access
Polycyclic Aromatic Hydrocarbons
Petroleum
Metabolism
Toxicity
Embryonic Stem Cells
1 Citation (Scopus)

Tools and rules for modelling uptake and bioaccumulation of nanomaterials in invertebrate organisms

Van Den Brink, N. W., Jemec Kokalj, A., Silva, P. V., Lahive, E., Norrfors, K., Baccaro, M., Khodaparast, Z., Loureiro, S., Drobne, D., Cornelis, G., Lofts, S., Handy, R. D., Svendsen, C., Spurgeon, D. & Van Gestel, C. A. M., Jul 2019, In : Environmental Science: Nano. 6, 7, p. 1985-2001 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bioaccumulation
Nanostructured materials
bioaccumulation
invertebrate
modeling
6 Citations (Scopus)
Open Access
Pyrrolizidine Alkaloids
Liver
Computer Simulation
Toxicity
Kinetics
2018
6 Citations (Scopus)

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Dimopoulou, M., Verhoef, A., Gomes, C. A., van Dongen, C. W., Rietjens, I. M. C. M., Piersma, A. H. & van Ravenzwaay, B., 1 Apr 2018, In : Toxicology Letters. 286, p. 10-21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Azoles
Embryonic Stem Cells
Stem cells
Cell culture
Assays
9 Citations (Scopus)
Silver
earthworm
silver
Dissolution
Aging of materials
3 Citations (Scopus)

Anti-nociceptive effect of methanol extract of leaves of Senna singueana in mice

Hishe, H. Z., Ambech, T. A., Hiben, M. G. & Fanta, B. S., 10 May 2018, In : Journal of Ethnopharmacology. 217, p. 49-53

Research output: Contribution to journalArticleAcademicpeer-review

Senna Extract
Methanol
Analgesics
Acetic Acid
Formaldehyde
1 Citation (Scopus)

Avoidance tests as a tool to detect sublethal effects of oil-impacted sediments

Szczybelski, A. S., Kampen, T., Vromans, J., Peeters, E. T. H. M., van den Heuvel-Greve, M. J., van den Brink, N. W. & Koelmans, A. A., Jun 2018, In : Environmental Toxicology and Chemistry. 37, 6, p. 1757-1766

Research output: Contribution to journalArticleAcademicpeer-review

sublethal effect
Sediments
Oils
oil
Amphipoda
3 Citations (Scopus)

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Zare Jeddi, M., Eshaghi Gorji, M., Rietjens, I. M. C. M., Louisse, J., Bruinen de Bruin, Y. & Liska, R., 23 Oct 2018, In : International Journal of Environmental Research and Public Health. 15, 11, 2336.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Environmental Monitoring
Dibutyl Phthalate
phthalic acid
Health
Safety
3 Citations (Scopus)

Biotransformation and bioactivation reactions – 2017 literature highlights

Khojasteh, S. C., Miller, G. P., Mitra, K. & Rietjens, I. M. C. M., 3 Jul 2018, In : Drug Metabolism Reviews. 50, 3, p. 221-255

Research output: Contribution to journalArticleAcademicpeer-review

Biotransformation
Toxicology
Industry
Students
13 Citations (Scopus)

Decision tree models to classify nanomaterials according to the DF4nanoGrouping scheme

Gajewicz, A., Puzyn, T., Odziomek, K., Urbaszek, P., Haase, A., Riebeling, C., Luch, A., Irfan, M. A., Landsiedel, R., van der Zande, M. & Bouwmeester, H., Jan 2018, In : Nanotoxicology. 12, 1, p. 1-17

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Decision Trees
Nanostructures
Decision trees
Nanostructured materials
Protein Carbonylation
19 Citations (Scopus)

Detection of titanium particles in human liver and spleen and possible health implications

Heringa, M. B., Peters, R. J. B., Bleys, R. L. A. W., van der Lee, M. K., Tromp, P. C., van Kesteren, P. C. E., van Eijkeren, J. C. H., Undas, A. K., Oomen, A. G. & Bouwmeester, H., 11 Apr 2018, In : Particle and Fibre Toxicology. 15, 1, 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Titanium
Liver
Spleen
Health
Health risks
20 Citations (Scopus)

Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota

Bouwmeester, H., van der Zande, M. & Jepson, M. A., Jan 2018, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 10, 1, 12 p., e1481.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanostructures
Nanostructured materials
Tissue
Food
Nanoparticles
7 Citations (Scopus)

Effects of systematic variation in size and surface coating of silver nanoparticles on their in vitro toxicity to macrophage RAW 264.7 cells

Makama, S. I., Kloet, S. K., Piella, J., van den Berg, J. H. J., de Ruijter, N. C. A., Puntes, V. F., Rietjens, I. M. C. M. & van den Brink, N. W., 1 Mar 2018, In : Toxicological sciences. 162, 1, p. 79-88

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Silver
Nanoparticles
Toxicity
Reactive Oxygen Species
2 Citations (Scopus)
Open Access
Food safety
Food Safety
Expert Testimony
Kinetics
Animals
10 Citations (Scopus)

Exposure assessment of process-related contaminants in food by biomarker monitoring

Rietjens, I. M. C. M., Dussort, P., Günther, H., Hanlon, P., Honda, H., Mally, A., O’Hagan, S., Scholz, G., Seidel, A., Swenberg, J., Teeguarden, J. & Eisenbrand, G., Jan 2018, In : Archives of Toxicology. 92, 1, p. 15-40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Process Assessment (Health Care)
Biomarkers
Impurities
Food
Monitoring

Impacto de las variables ambientales en los niveles de PCDD/F y dl-PCB en la leche de la región agrícola de Chile

Translated title of the contribution: Impact of environmental variables on PCDD/F and dl-PCB levels in dairy milk of the farming region of ChilePizarro-Aránguiz, N., García-Mendoza, D., Muñoz, R., San Martín, B. & Morales, R., 1 Jan 2018, In : Ciencia e Investigacion Agraria. 45, 2, p. 109-119

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
polychlorinated dibenzodioxins
Dioxins
dioxins
Chile
Polychlorinated Biphenyls
3 Citations (Scopus)

Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces

Behr, C., Ramírez-Hincapié, S., Cameron, H. J., Strauss, V., Walk, T., Herold, M., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Oct 2018, In : Toxicology Letters. 296, p. 139-151

Research output: Contribution to journalArticleAcademicpeer-review

Lincosamides
Microbiota
Metabolites
Feces
Rats
6 Citations (Scopus)

Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport

Abdelkhaliq, A., van der Zande, M., Punt, A., Helsdingen, R., Boeren, S., Vervoort, J. J. M., Rietjens, I. M. C. M. & Bouwmeester, H., 15 Sep 2018, In : Journal of Nanobiotechnology. 16, 1, 70.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanoparticles
Polystyrenes
Adhesion
Proteins
Surface chemistry