Research Output 1976 2020

2020

Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays

Zhang, M., van Ravenzwaay, B. & Rietjens, I. M. C. M., 1 Jan 2020, In : Toxicological sciences : an official journal of the Society of Toxicology. 173, 1, p. 19-31 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bioassay
Biological Assay
Rats
Coumestrol
Methoxychlor

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients

Rietjens, I. M. C. M., Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, P. F., Hecht, S. S., Rosol, T. J., Davidsen, J. M., Harman, C. L., Murray, I. J. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110949.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Myroxylon
Cinnamomum
Flavors
flavorings
Cassia

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, P. F., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Agathosma betulina
Anethum graveolens
Carum
Mints
caraway

Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

Schrenk, D., Gao, L., Lin, G., Mahony, C., Mulder, P. P. J., Peijnenburg, A., Pfuhler, S., Rietjens, I. M. C. M., Rutz, L., Steinhoff, B. & These, A., Feb 2020, In : Food and Chemical Toxicology. 136, 111107.

Research output: Contribution to journalArticleAcademicpeer-review

Pyrrolizidine Alkaloids
pyrrolizidine alkaloids
Risk assessment
risk assessment
Toxicity
2019

Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment

Gilbert Sandoval, I., Wesseling, S. & Rietjens, I. M. C. M., 15 Oct 2019, In : Toxicology Reports. 6, p. 1135-1142 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Aflatoxin B1
Mexico
Risk assessment
Zea mays
Needs Assessment
Pyrrolizidine Alkaloids
Food
Population
Liver
Chinese Traditional Medicine
1 Citation (Scopus)

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

Behr, C., Slopianka, M., Haake, V., Strauss, V., Sperber, S., Kamp, H., Walk, T., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Jan 2019, In : Toxicology and Applied Pharmacology. 363, p. 79-87

Research output: Contribution to journalArticleAcademicpeer-review

Metabolome
Bile Acids and Salts
Feces
Rats
Anti-Bacterial Agents
1 Citation (Scopus)

Bioaccumulation of polycyclic aromatic hydrocarbons by Arctic and temperate benthic species

Szczybelski Ciordia, A. S., Diepens, N. J., van den Heuvel-Greve, M. J., van den Brink, N. W. & Koelmans, A. A., Apr 2019, In : Environmental Toxicology and Chemistry. 38, 4, p. 883-895

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biota
Bioaccumulation
Polycyclic Aromatic Hydrocarbons
bioaccumulation
PAH
2 Citations (Scopus)
Polycyclic Aromatic Hydrocarbons
Pyrene
Biomarkers
biotransformation
Polycyclic aromatic hydrocarbons

Biotransformation and bioactivation reactions – 2018 literature highlights

Khojasteh, S. C., Bumpus, N. N., Driscoll, J. P., Miller, G. P., Mitra, K., Rietjens, I. M. C. M. & Zhang, D., 6 Aug 2019, In : Drug Metabolism Reviews. 51, 2, p. 121-161

Research output: Contribution to journalArticleAcademicpeer-review

Biotransformation
Pharmaceutical Preparations
Drug Discovery
Computer Simulation
Toxicology
1 Citation (Scopus)

Bioturbation of Ag2S-NPs in soil columns by earthworms

Baccaro, M., Harrison, S., van den Berg, H., Sloot, L., Hermans, D., Cornelis, G., van Gestel, C. A. M. & van den Brink, N. W., Sep 2019, In : Environmental Pollution. 252, p. 155-162

Research output: Contribution to journalArticleAcademicpeer-review

Oligochaeta
Soil
Soils
Sewage
Rain
Macrophages
Cadmium
Mast Cells
Cells
Modulation
1 Citation (Scopus)

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Kramer, N. I., Hoffmans, Y., Wu, S., Thiel, A., Thatcher, N., Allen, T. E. H., Levorato, S., Traussnig, H., Schulte, S., Boobis, A., Rietjens, I. M. C. M. & Vinken, M., Aug 2019, In : Archives of Toxicology. 93, 8, p. 2115-2125

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food additives
Food Additives
Safety
Databases
Cardiovascular system

Chemical hazards in foods of animal origin

Smulders, F. J. M. (ed.), Rietjens, I. M. C. M. (ed.) & Rose, M. D. (ed.), 2019, Wageningen: Wageningen Academic Publishers. 669 p. (Food safety assurance and veterinary public health; vol. 7)

Research output: Book/ReportBook editingAcademic

chemical hazards
animal-based foods
risk reduction
xenobiotics
honey

Digestion-on-a-chip: A continuous-flow modular microsystem recreating enzymatic digestion in the gastrointestinal tract

De Haan, P., Ianovska, M. A., Mathwig, K., Van Lieshout, G. A. A., Triantis, V., Bouwmeester, H. & Verpoorte, E., 5 Apr 2019, In : Lab on a Chip. 19, 9, p. 1599-1609 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microsystems
Nutrients
Gastrointestinal Tract
Digestion
Digestive system
Open Access
Liquid chromatography
Liquid Chromatography
Biological Availability
Mass spectrometry
Mass Spectrometry
1 Citation (Scopus)

Ecology and conservation of the endemic Bawean warty pig Sus verrucosus blouchi and Bawean deer Axis kuhlii

Rode-Margono, E. J., Khwaja, H., Rademaker, M. & Semiadi, G., 27 Mar 2019, In : Oryx.

Research output: Contribution to journalArticleAcademicpeer-review

Sus
pig
deer
ecology
swine
Open Access
Bioassay
Shellfish
Genes
Assays
Okadaic Acid

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)mediated gene expression in vitro

Hiben, M. G., De Haan, L., Spenkelink, B., Wesseling, S., Louisse, J., Vervoort, J. & Rietjens, I. M. C. M., 1 Apr 2019, In : PLoS ONE. 14, 4, e0215155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Maerua
glucobrassicin
Gene expression
Cytotoxicity
Fruits

Excreta emissions in progeny of low and high enteric methane yield selection line sheep fed pasture of different qualities

Jonker, A., MacLean, S., Woyimo Woju, C., Garcia Rendon Calzada, M., Yu, W., Molano, G., Hickey, S., Pinares-Patiño, C. S., McEwan, J. C., Janssen, P. H., Sandoval, E., Lewis, S. & Rowe, S., Nov 2019, In : Animal Feed Science and Technology. 257, 114289.

Research output: Contribution to journalArticleAcademicpeer-review

excreta
methane
pastures
dry matter intake
sheep
3 Citations (Scopus)

Facilitated delignification in CAD deficient transgenic poplar studied by confocal Raman spectroscopy imaging

Segmehl, J. S., Keplinger, T., Krasnobaev, A., Berg, J. K., Willa, C. & Burgert, I., 5 Jan 2019, In : Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 206, p. 177-184

Research output: Contribution to journalArticleAcademicpeer-review

Delignification
biomass
computer aided design
lignin
Raman spectroscopy
3 Citations (Scopus)

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Citrus
Flavors
flavorings
ingredients
flavor

Hatching failure and accumulation of organic pollutants through the terrestrial food web of a declining songbird in Western Europe

van Oosten, H. H., van den Burg, A. B., Arlt, D., Both, C., van den Brink, N. W., Chiu, S., Crump, D., Jeppsson, T., de Kroon, H., Traag, W. & Siepel, H., 10 Feb 2019, In : Science of the Total Environment. 650, p. 1547-1553

Research output: Contribution to journalArticleAcademicpeer-review

Dioxins
songbird
Organic pollutants
Birds
Nutrition
1 Citation (Scopus)

Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests

Gebrelibanos Hiben, M., Kamelia, L., de Haan, L., Spenkelink, B., Wesseling, S., Vervoort, J. & Rietjens, I. M. C. M., 15 Sep 2019, In : Journal of Ethnopharmacology. 241, 111978.

Research output: Contribution to journalArticleAcademicpeer-review

Aryl Hydrocarbon Receptors
Fruit
Zebrafish
Isothiocyanates
Estrogen Receptor alpha

Hazards associated with animal feed

de Jong, J., Kleter, G., Banach, J., van Raamsdonk, L., Hoogenboom, R., de Nijs, M., van der Fels-Klerx, I., Kok, E., Slot, M., Bouwmeester, H. & Noordam, M., 2019, Rome: Food and Agriculture Organization of the United Nations. 265 p. (Report / FAO Animal Production and Health; no. 14)

Research output: Book/ReportReportProfessional

Open Access

Induction of EpRE-mediated gene expression by a series of mediterranean botanicals and their constituents

Papadi, G., Wesseling, S., Troganis, A. N., Vervoort, J. & Rietjens, I. M. C. M., 10 Aug 2019, In : Journal of Ethnopharmacology. 240, 13 p., 111940.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Frangula
Rhamnus
Gene Expression
Liquid Chromatography
Mass Spectrometry

Influence of the gut microbiome on plasma metabolite patterns

Behr, C., 2019, Wageningen: Wageningen University. 187 p.

Research output: Thesisinternal PhD, WU

Open Access
digestive system
metabolites
metabolome
feces
bile acids

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J., Rietjens, I. M. C. M. & Strikwold, M., 1 Oct 2019, In : Archives of Toxicology. 93, 10, p. 2943-2960 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Liver
Toxicity
Kinetics
Population
Pyrrolizidine Alkaloids
Open Access
Maerua
famine
functional foods
developmental toxicity
seed extracts
1 Citation (Scopus)
Open Access
Aryl Hydrocarbon Receptors
Polycyclic Aromatic Hydrocarbons
Petroleum
Toxicity
Dimethyl Sulfoxide
2 Citations (Scopus)

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Suparmi, S., Ginting, A. J., Mariyam, S., Wesseling, S. & Rietjens, I. M. C. M., 1 Mar 2019, In : Food and Chemical Toxicology. 125, p. 467-478

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
methyleugenol
Eugenol
Beverages
eugenol
Risk assessment
1 Citation (Scopus)

Novel approaches to derive points of departure for food chemical risk assessment

Levorato, S., Rietjens, I. M. C. M., Carmichael, P. L. & Hepburn, P. A., Jun 2019, In : Current Opinion in Food Science. 27, p. 139-144

Research output: Contribution to journalArticleAcademicpeer-review

chemical risk assessment
toxicogenomics
Food
in vivo studies
toxicity testing

Novel strategies for risk assessment of pyrrolizidine alkaloids

Chen, L., 2019, Wageningen: Wageningen University. 245 p.

Research output: Thesisinternal PhD, WU

Open Access
Pyrrolizidine Alkaloids
Herbal Medicine
Risk Management
Liver
Dietary Supplements
1 Citation (Scopus)

Online and in situ analysis of organs-on-a-chip

Santbergen, M. J. C., van der Zande, M., Bouwmeester, H. & Nielen, M. W. F., 1 Jun 2019, In : TrAC - Trends in Analytical Chemistry. 115, p. 138-146 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell culture
Metabolism
Sugars
Culture Media
Salts
Open Access
Pyrrolizidine Alkaloids
Liver
Dosimetry
Rats
Kinetics
3 Citations (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Organic Anion Transporters
Proximal Kidney Tubule
Anions
Indican
Kidney
30 Citations (Scopus)

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Bixby, H., Bentham, J., Zhou, B., Di Cesare, M., Paciorek, C. J., Bennett, J. E., Taddei, C., Stevens, G. A., Rodriguez-Martinez, A., Carrillo-Larco, R. M., Khang, Y. H., Sorić, M., Gregg, E. W., Miranda, J. J., Bhutta, Z. A., Savin, S., Sophiea, M. K., Iurilli, M. L. C., Solomon, B. D., Cowan, M. J. & 30 others, Riley, L. M., Danaei, G., Bovet, P., Chirita-Emandi, A., Hambleton, I. R., Hayes, A. J., Ikeda, N., Kengne, A. P., Laxmaiah, A., Li, Y., McGarvey, S. T., Mostafa, A., Neovius, M., Starc, G., Zainuddin, A. A., Abarca-Gómez, L., Abdeen, Z. A., Abdrakhmanova, S., Abdul Ghaffar, S., Abdul Hamid, Z., Abubakar Garba, J., Ferrieres, J., He, Y., Jacobs, J. M., Kromhout, D., Ma, G., Visser, M., Wang, Q., Wang, Y. X. & Wang, Y. W., 9 May 2019, In : Nature. 569, 7755, p. 260-264 5 p.

Research output: Contribution to journalLetterAcademicpeer-review

Open Access
Body Mass Index
Obesity
Malnutrition
Urbanization
Africa South of the Sahara

Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic

Prinsloo, G., Steffens, F., Vervoort, J. & Rietjens, I. M. C. M., Dec 2019, In : Critical Reviews in Toxicology. p. 1-13

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
exposure scenario
Pyrrolizidine Alkaloids
herbal tea
pyrrolizidine alkaloids
Herbal Medicine
1 Citation (Scopus)
Open Access
Pyrrolizidine Alkaloids
pyrrolizidine alkaloids
Risk assessment
pharmacokinetics
risk assessment
1 Citation (Scopus)

Strategies for robust and accurate experimental approaches to quantify nanomaterial bioaccumulation across a broad range of organisms

Petersen, E. J., Mortimer, M., Burgess, R. M., Handy, R., Hanna, S., Ho, K. T., Johnson, M., Loureiro, S., Selck, H., Scott-Fordsmand, J. J., Spurgeon, D., Unrine, J., Van Den Brink, N. W., Wang, Y., White, J. & Holden, P., Jun 2019, In : Environmental Science: Nano. 6, 6, p. 1619-1656 38 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bioaccumulation
Nanostructured materials
bioaccumulation
analytical method
organism
3 Citations (Scopus)

The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy

Adam, A. H. B., Zhang, M., de Haan, L. H. J., van Ravenzwaay, B., Louisse, J. & Rietjens, I. M. C. M., Jul 2019, In : Archives of Toxicology. 93, 7, p. 2021-2033

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diethylstilbestrol
Toxicity
Rats
Testing
Estrogen Receptor alpha
Open Access
Polycyclic Aromatic Hydrocarbons
Petroleum
Metabolism
Toxicity
Embryonic Stem Cells
Open Access
Polycyclic Aromatic Hydrocarbons
Petroleum
Embryonic Stem Cells
Aryl Hydrocarbon Receptors
Luciferases
1 Citation (Scopus)

Tools and rules for modelling uptake and bioaccumulation of nanomaterials in invertebrate organisms

Van Den Brink, N. W., Jemec Kokalj, A., Silva, P. V., Lahive, E., Norrfors, K., Baccaro, M., Khodaparast, Z., Loureiro, S., Drobne, D., Cornelis, G., Lofts, S., Handy, R. D., Svendsen, C., Spurgeon, D. & Van Gestel, C. A. M., Jul 2019, In : Environmental Science: Nano. 6, 7, p. 1985-2001 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bioaccumulation
Nanostructured materials
bioaccumulation
invertebrate
modeling
6 Citations (Scopus)
Open Access
Pyrrolizidine Alkaloids
Liver
Computer Simulation
Toxicity
Kinetics
2018
6 Citations (Scopus)

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Dimopoulou, M., Verhoef, A., Gomes, C. A., van Dongen, C. W., Rietjens, I. M. C. M., Piersma, A. H. & van Ravenzwaay, B., 1 Apr 2018, In : Toxicology Letters. 286, p. 10-21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Azoles
Embryonic Stem Cells
Stem cells
Cell culture
Assays

Advancement of benthic indicators and biomarker-based tools for biomonitoring and risk assessment in the Barents Sea region

Szczybelski Ciordia, A. S., 2018, Wageningen: Wageningen University. 240 p.

Research output: Thesisinternal PhD, WU

Open Access
biomonitoring
biomarker
risk assessment
oil
bioindicator