Research Output 1936 2020

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Patent
2019

Enrichment of nucleic acids

Bau, H., Song, J., Liu, C., Mauk, M., van der Oost, J. & Hegge, J. W., 19 Sep 2019, Patent No. WO2019178346, Priority date 14 Mar 2018

Research output: PatentOther research output

Open Access
Nucleic Acids
Antigens
Molecules

Fecal matter for prevention or treatment of autoimmune diseases

Nieuwdorp, M. & de Vos, W. M., 6 Sep 2019, Patent No. WO2019168401, Priority date 20 Jul 2018

Research output: PatentOther research output

Open Access
MicroRNAs
Duodenum
Feces
Bacteriophages
Autoimmune Diseases

Thermostable Cas9 nucleases with reduced off-target activity

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 18 Apr 2019, Patent No. WO2019072596, Priority date 10 Oct 2017

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Gene Deletion
Geobacillus
Pseudomonas putida
Temperature
2018

Alcohol acetyl transferases for alkyl alkanoate production

Kruis, A. J., Levisson, M., Mars, A. E., Kengen, S. W. M., van der Oost, J., Sanders, J. P. M. & Weusthuis, R. A., 8 Jun 2018, Patent No. WO2018099719, Priority date 1 Dec 2016

Research output: PatentOther research output

Open Access
Transferases
Kluyveromyces
Acetyl Coenzyme A
Alcohols
Peptides

Microbial genome editing

van der Oost, J., van Kranenburg, R., Bosma, E. F. & Mougiakos, I., 11 May 2018, Patent No. WO2018083128, Priority date 11 Feb 2016

Research output: PatentOther research output

Open Access
Microbial Genome
Homologous Recombination
Temperature
Plasmids
Microbial Genes

Prokaryotic argonaute proteins and uses thereof

van der Oost, J. & Hegge, J. W., 18 Jan 2018, Patent No. WO2018011236, Priority date 7 Dec 2016

Research output: PatentOther research output

Open Access
Argonaute Proteins
Nucleic Acids
Biotechnology
Peptides
Synthetic Biology

Thermostable Cas9 nucleases

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 21 Jun 2018, Patent No. WO2018108339, Priority date 14 Dec 2016

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Genetic Engineering
Nucleic Acids
Peptides
Polynucleotides

Thermostable Cas9 nucleases

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 21 Jun 2018, Patent No. WO2018109101, Priority date 14 Dec 2016

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Guide RNA
Polynucleotides
Endonucleases
Plasmids
2017

DNA modification

Vlot, M. & Brouns, S. J. J., 6 Apr 2017, Patent No. WO2017055514, Priority date 30 Sep 2015

Research output: PatentOther research output

Open Access
Nucleic Acids
Patents and inventions
DNA
Genes
Genetic engineering

Improved CRISPR-Cas9 genome editing tool

Louwen, R. & van der Oost, J., 14 Sep 2017, Patent No. WO2017155408, Priority date 11 Mar 2016

Research output: PatentOther research output

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Proteins
Gene Editing

Improved CRISPR-Cpf1 genome editing tool 

van der Oost, J., van Baarlen, P. & Louwen, R., 14 Sep 2017, Patent No. WO2017155407, Priority date 11 Mar 2016

Research output: PatentOther research output

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Proteins
Gene Editing

Novel bacterial species 

de Vos, W. M. & Belzer, C., 19 Oct 2017, Patent No. WO2017178496, Priority date 11 Apr 2016

Research output: PatentOther research output

Open Access
digestive system
Python
cosmetics
mucus
probiotics

Use of pasteurized Akkermansia for treating metabolic disorders

Cani, P., Everard, A., Plovier, H., Druart, C., de Vos, W. M. & Belzer, C., 16 Mar 2017, Patent No. WO2017042347, Priority date 10 Sep 2015

Research output: PatentOther research output

Open Access
Weight Loss
Pharmaceutical Preparations
2016

Bacteria-comprising compositions and methods of using the same for treating and/or preventing gastrointestinal, metabolic and/or other diseases

de Vos, W. M., 14 Jul 2016, Patent No. WO2016110585, Priority date 9 Jan 2015

Research output: PatentOther research output

Open Access
Butyrates
Lysine
Bacteria
Advanced Glycosylation End Products
Probiotics

Compounds against ralstonia pickettii for use in the treatment of insulin resistance, and method of diagnosis of insulin resistance  

Nieuwdorp, M., de Vos, W. M. & de Pauw, E. S. D., 3 Mar 2016, Patent No. WO2016030500, Priority date 28 Aug 2014

Research output: PatentOther research output

Open Access
Ralstonia pickettii
Insulin Resistance
Nucleic Acids
Antibodies
Type 2 Diabetes Mellitus

Method of culturing Akkermansia

Belzer, C. & de Vos, W. M., 10 Nov 2016, Patent No. WO2016177801, Priority date 5 Jun 2015

Research output: PatentOther research output

Open Access
drugs
biomass
animals
methodology

Nuclease-mediated genome editing

van der Oost, J., 20 Oct 2016, Patent No. WO2016166340, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Nucleic Acids
Peptides
Synthetic Biology
Synthetic Genes
Genetic Techniques

Riboswitch-controlled screening and selection of desired biocatalysts 

Creutzburg, S. C. A. & van der Oost, J., 20 Oct 2016, Patent No. WO2016166303, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Riboswitch
Enzymes
RNA Splicing
Bacterial Genomes
Reading Frames

Riboswitch inducible gene expression

Creutzburg, S. C. A. & van der Oost, J., 20 Oct 2016, Patent No. WO2016166310, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Riboswitch
Gene Expression
Enzymes
Reading Frames
Reporter Genes

Thermostable Cas9 nucleases

van der Oost, J., Daas, M. J. A., Kengen, S. W. M. & de Vos, W. M., 15 Dec 2016, Patent No. WO2016198361, Priority date 12 Jun 2015

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Genetic Engineering
Nucleic Acids
DNA Cleavage
Peptides
2015

Systematic optimization of coding sequence for functional protein expression

van der Oost, J., 9 Apr 2015, Patent No. WO2015048989, Priority date 2 Oct 2013

Research output: PatentOther research output

Open Access
Codon
Proteins
2014

DNA-guided DNA interference by a prokaryotic Argonaute

van der Oost, J. & Swarts, D. C., 27 Nov 2014, Patent No. WO2014189628, Priority date 11 Apr 2013

Research output: PatentOther research output

Open Access
Nucleic Acids
DNA
Amino Acids
Chemical analysis

Genetically engineered micro-organisms for production of fatty acids

Weusthuis, R. A., van der Oost, J. & Eggink, G., 30 Jan 2014, Patent No. WO2014016328, Priority date 25 Jul 2012

Research output: PatentOther research output

Open Access
fatty acid
micro-organism
method

Use of Akkermansia for treating metabolic disorders

Cani, P., Everard, A., Belzer, C. & de Vos, W. M., 22 May 2014, Patent No. WO2014076246, Priority date 19 Nov 2012

Research output: PatentOther research output

Open Access
Weight Loss
Pharmaceutical Preparations
2013

Identification of subjects at risk of developing irritable bowel syndrome

Tuk, L., Rajilic-Stojanovic, M. & de Vos, W. M., 24 Jan 2013, Patent No. WO2013012332, Priority date 19 Jul 2011

Research output: PatentOther research output

Open Access
Irritable Bowel Syndrome
Psychological Stress

Method for preventing and/or treating insulin resistance

Nieuwdorp, M. & de Vos, W. M., 7 Mar 2013, Patent No. WO2013032328, Priority date 31 Aug 2011

Research output: PatentOther research output

Open Access
Insulin Resistance
Alcaligenes faecalis
Eubacterium
Lipodystrophy
Endocrine System Diseases

Modified cascade ribonucleoproteins and uses thereof 

Brouns, S. J. J. & van der Oost, J., 4 Jul 2013, Patent No. WO2013098244, Priority date 30 Dec 2011

Research output: PatentOther research output

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Ribonucleoproteins
CRISPR-Associated Proteins
Nucleic Acids
Antiviral Agents
2012

Probiotics with enhanced survival properties

van Bokhorst-van de Veen, H., Lee, I., Wels, M., de Vos, P., Bron, P. A., Bongers, R. S., Wiersma, A. & Kleerebezem, M., 8 Nov 2012, Patent No. WO2012150861, Priority date 2 May 2011

Research output: PatentOther research output

Open Access
Probiotics
Bacteria
Polynucleotides
Food

Process for polylactic acid production using Monascus

Weusthuis, R. A., Wolbert, E. J. H., Springer, J., van der Oost, J. & Eggink, G., 3 May 2012, Patent No. WO2012055997, Priority date 28 Oct 2010

Research output: PatentOther research output

Open Access
polylactic acid
Monascus
polymerization
lactic acid
fermentation

Use of Monascus in organic acid production

Weusthuis, R. A., Wolbert, E. J. H., Springer, J., van der Oost, J. & Eggink, G., 3 May 2012, Patent No. WO2012055998, Priority date 28 Oct 2010

Research output: PatentOther research output

Open Access
Monascus
organic acids and salts
methodology
2011

Method for improving flavor production in a fermented food product

Pastink, M. I., de Vos, W. M., Sikkema, J. & Hugenholtz, J., 17 Mar 2011, Patent No. WO2011031141, Priority date 8 Sep 2009

Research output: PatentOther research output

Open Access
fermented foods
foods
flavor
glutamate dehydrogenase
methodology

Methods for diagnosing irritable bowel syndrome

Tuk, L. & de Vos, W. M., 14 Apr 2011, Patent No. WO2011043654, Priority date 10 May 2009

Research output: PatentOther research output

Open Access
Irritable Bowel Syndrome
2010

Novel peptides and methods for producing them

de Vos, W. M., Palva, A., Palva, I., Reunanen, J., von Ossowski, I., Satokari, R. M., Vesterlund, S., Kankainen, M., Salusjarvi, T. & Tynkkynen, S., 5 Aug 2010, Patent No. US2010196524, Priority date 2 Feb 2009

Research output: PatentOther research output

Open Access
Polynucleotides
Peptides
Bacterial Adhesion
Biological Science Disciplines
Food Industry
2009

Method for taking a plurality of samples

Sprenkels, A. J., Bomer, J. G., Ingham, C. J., van Hylckama Vlieg, J. E. T., de Vos, W. M., van den Berg, A. & ten Haaft, P., 25 Jun 2009, Patent No. WO2009078724, Priority date 19 Dec 2007

Research output: PatentOther research output

Open Access
inventions
optical microscopes
2006

Fungal polygalacturonase with improved maceration properties

Benen, J. A. E., Joosten, R., Kars, I., Krooshof, G. H., Sibbel-Wagemakers, C. A. M. & van Kan, J. A. L., 11 Jan 2006, Patent No. EP1614748

Research output: PatentOther research output

Open Access
maceration
polygalacturonase
enzymes
nucleic acids
glycosidic linkages
2005

Site-specific intestinal delivery and/or production of biologically active substances

Bron, P. A., de Vos, W. M. & Kleerebezem, M., 6 May 2005, Patent No. WO2005040387

Research output: PatentOther research output

Open Access
Nucleic Acids
Gastrointestinal Tract
1996

Stable ADP-dependent kinases, and preparation and use thereof

Kengen, S., Stams, A. J. M. & de Vos, W. M., 2 Jan 1996, Patent No. NL9400836

Research output: PatentOther research output

Open Access
Adenosine Diphosphate
Phosphotransferases
Sugars
Enzymes
Polyphosphates
1988

Removing organic contaminants from soil - by homogenising and breaking down soil, and treating with microorganisms

Zehnder, A. J. B., 16 Jun 1988, Patent No. NL8602985, Priority date 24 Nov 1986

Research output: PatentOther research output

Open Access
microorganism
comminution
pollutant
soil
organic matter
1987

Process for the preparation of a d-alfa-amino acid from the corresponding alfa-keto acid.

van den Tweel, A. J. J., Ogg, L. H. P. & de Bont, J. A. M., 1987, Patent No. EP0315786, Priority date 17 May 1986

Research output: PatentOther research output

Open Access
Keto Acids
Amino Acids
Patents and inventions
tyrosine-repressible transaminase
4-hydroxyphenylglycine
1985

Process for the recovery of a gelforming polysaccharide, the recovered polysaccharide as well as the gel formed therewith

Zevenhuizen, L. P. T. M. & van Neerven, A. R. W., 1 Jul 1985, Patent No. NL8304304

Research output: PatentOther research output

Open Access