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Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human colon

Chung, W. S. F., Meijerink, M., Zeuner, B., Holck, J., Louis, P., Meyer, A. S., Wells, J. M., Flint, H. J. & Duncan, S. H., 1 Nov 2017, In : FEMS microbiology ecology. 93, 11

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Probiotic modulation of dendritic cells and T cell responses in the intestine

Meijerink, M. & Wells, J., 2010, In : Beneficial Microbes. 1, 4, p. 317-326

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine.

Smelt, M. J., de Haan, B. J., Bron, P. A., van Swam, I., Meijerink, M., Wells, J., Faas, M. M. & de Vos, P., 2013, In : PLoS ONE. 8, 7, e68952.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Production of aroma compounds in lactic fermentations

Smid, E. J. & Kleerebezem, M., 2014, In : Annual Review of Food Science and Technology. 5, p. 313-326

Research output: Contribution to journalArticleAcademicpeer-review

95 Citations (Scopus)

Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-a and interleukin-18 in BALB/c and severe combined immunodeficiency mice

Hudcovic, T., Kolinska, J., Klepetar, J., Stepankova, R., Rezanka, T., Srutkova, D., Schwarzer, M., Erban, V., Du, Z., Wells, J., Hrncir, T., Tlaskalova-Hogenova, H. & Kozakova, H., 2012, In : Clinical and Experimental Immunology. 167, 2, p. 356-365

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Protein, peptide, amino acid composition, and potential functional properties of existing and novel dietary protein sources for monogastrics

Kar, S. K., Jansman, A. J. M., Boeren, S., Kruijt, L. & Smits, M. A., 2016, In : Journal of Animal Science. 94, 7 supplement 3, p. 30-39

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double-blind, placebo-controlled, crossover trial

Esser, D., Geleijnse, J. M., Matualatupauw, J. C., Dower, J. I., Kromhout, D., Hollman, P. C. H. & Afman, L. A., 19 Apr 2018, In : PLoS ONE. 13, 4, 15 p., e0194229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

Velikova, N., Fulle, S., Manso, A. S., Mechkarska, M., Finn, P., Conlon, J. M., Oggioni, M. R., Wells, J. M. & Marina, A., 13 May 2016, In : Scientific Reports. 6, 26085.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Quantitative physiology of Lactococcus lactis at extreme low-growth rates

Ercan, O., Smid, E. J. & Kleerebezem, M., 2013, In : Environmental Microbiology. 15, 8, p. 2319-2332

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Rationale and prospects of targeting bacterial two-component systems for antibacterial treatment of cystic fibrosis patients

Velikova, N. & Wells, J. M., 2016, In : Current Drug Targets. 17, 16

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer

de Azevedo, M., Meijerink, M., Taverne, N., Pereira, V. B., LeBlanc, J. G., Azevedo, V., Miyoshi, A., Langella, P., Wells, J. M. & Chatel, J. M., 2015, In : Vaccine. 33, 38, p. 4807-4812

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Recombinant lactic acid bacteria as mucosal biotherapeutic agents

Daniel, C., Roussel, Y., Kleerebezem, M. & Pot, B., 2011, In : Trends in Biotechnology. 29, 10, p. 499-508

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)

Reconstruction of the regulatory network of Lactobacillus plantarum WCFS1 on basis of correlated gene expression and conserved regulatory motifs

Wels, M., Overmars, L., Francke, C., Kleerebezem, M. & Siezen, R. J., 2011, In : Microbial Biotechnology. 4, 3, p. 333-344

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

REG3¿-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum

Loonen, L. M. P., Kranenbarg-Stolte, H. H., Jaklofsky, M. T. J., Meijerink, M., Dekker, J., van Baarlen, P. & Wells, J., 2014, In : Mucosal Immunology. 7, p. 939-947

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R. J. & Wells, J., 2010, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 298, 6, p. G851-G859

Research output: Contribution to journalArticleAcademicpeer-review

275 Citations (Scopus)

Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

van Baarlen, P., Wells, J. & Kleerebezem, M., 2013, In : Trends in Immunology. 34, 5, p. 208-215

Research output: Contribution to journalArticleAcademicpeer-review

154 Citations (Scopus)

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. & Roy, N. C., 2011, In : The Journal of Nutrition. 141, 5, p. 769-776

Research output: Contribution to journalArticleAcademicpeer-review

463 Citations (Scopus)

Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

Bron, P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska, L. P., Kuipers, O. P., Kok, J. & Kleerebezem, M., 1 Apr 2019, In : Current Opinion in Biotechnology. 56, p. 61-68 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Resequencing of the Lactobacillus plantarum strain WJL genome

Martino, M. E., Bayjanov, J. R., Joncour, P., Hughes, S., Gillet, B., Kleerebezem, M., Siezen, R., van Hijum, S. A. F. T. & Leulier, F., 25 Nov 2015, In : Genome Announcements. 3, 6, e0138215.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Riboflavin Biosynthesis Is Associated with Assimilatory Ferric Reduction and Iron Acquisition by Campylobacter Jejuni.

Gaskin, D. J. H., Holmes, K., Mulholland, F. & Wells, J., 2007, In : Applied and Environmental Microbiology. 73, 24, p. 7819-7825

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
36 Citations (Scopus)

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J. M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K., Grarup, N., Jorgensen, T., Branslund, I., Nielsen, H. B., Juncker, A. S., Bertalan, M., Levenez, F. & 62 others, Pons, N., Rasmussen, S., Sunagawa, S., Tap, J., Tims, S., Zoetendal, E. G., Brunak, S., Clement, K., Dore, J., Kleerebezem, M., Kristiansen, K., Renault, P., Sicheritz-Ponten, T., de Vos, W. M., Zucker, J. D., Raes, J., Hansen, T., Bork, P., Wang, J., Ehrlich, S. D., Pederson, O., Guedon, E., Delorme, C., Layec, S., Khaci, G., van de Guchte, M., Vandemeulebrouck, G., Jamet, A., Dervyn, R., Sanchez, N., Maguin, E., Haimet, F., Winogradski, Y., Cultrone, A., Leclerc, M., Juste, C., Blottière, H., Pelletier, E., LePaslier, D., Artiguenave, F., Bruls, T., Weissenbach, J., Turner, K., Parkhill, J., Antolin, M., Manichanh, C., Casellas, F., Boruel, N., Varela, E., Torrejon, A., Guarner, F., Denariaz, G., Derrien, M., van Hylckama Vlieg, J. E. T., Veiga, P., Oozeer, R., Knol, J., Rescigno, M., Brechot, C., M'Rini, C., Mérieux, A. & Yamada, T., 2013, In : Nature. 500, 7464, p. 541-546

Research output: Contribution to journalArticleAcademicpeer-review

1582 Citations (Scopus)

Role of cell surface composition and lysis in static biofilm formation by Lactobacillus plantarum WCFS1

Fernández Ramírez, M. D., Nierop Groot, M. N., Smid, E. J., Hols, P., Kleerebezem, M. & Abee, T., 20 Apr 2018, In : International Journal of Food Microbiology. 271, p. 15-23

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

de Wit, N. J. W., Derrien, M., Bosch-Vermeulen, H., Oosterink, E., Keshtkar, S., Duval, C. N. C., de Vogel-van den Bosch, H. M., Kleerebezem, M., Muller, M. R. & van der Meer, R., 2012, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 303, 5, p. G589-G599

Research output: Contribution to journalArticleAcademicpeer-review

157 Citations (Scopus)

Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Elderman, M., Hugenholtz, F., Belzer, C., Boekschoten, M., van Beek, A., de Haan, B., Savelkoul, H., de Vos, P. & Faas, M., 18 Jun 2018, In : Biology of Sex Differences. 9, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Sex differences in lipid metabolism are affected by presence of the gut microbiota

Baars, A., Oosting, A., Lohuis, M., Koehorst, M., El Aidy, S., Hugenholtz, F., Smidt, H., Mischke, M., Boekschoten, M. V., Verkade, H. J., Garssen, J., van der Beek, E. M., Knol, J., de Vos, P., van Bergenhenegouwen, J. & Fransen, F., 1 Sep 2018, In : Scientific Reports. 8, 1, 13426.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)
Open Access
5 Citations (Scopus)

Small intestinal segment perfusion test in piglets: future applications in studying probiotics-gut crosstalk in infectious diarrhoea?

van der Meulen, J., Hulst, M. M., Smits, M. A. & Schuurman, T., 2010, In : Beneficial Microbes. 1, 4, p. 439-445

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Strain-specific features of extracellular polysaccharides and their impact on Lactobacillus plantarum-host interactions

Lee, I. C., Caggianiello, G., van Swam, I. I., Taverne, N., Meijerink, M., Bron, P. A., Spano, G. & Kleerebezem, M., 2016, In : Applied and Environmental Microbiology. 82, 13, p. 3959-3970

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
35 Citations (Scopus)

Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources

Genini, S., Badaoui, B., Sclep, G., Bishop, S. C., Waddington, D., Pinard van der Laan, M. H., Klopp, C., Cabau, C., Seyfert, H. M., Petzl, W., Jensen, K., Glass, E. J., de Greeff, A., Smith, H. E., Smits, M. A., Olsaker, I., Boman, G. M., Pisoni, G., Moroni, P., Castiglioni, B. & 6 others, Cremonesi, P., del Corvo, M., Foulon, E., Foucras, G., Rupp, R. & Giuffra, E., 2011, In : BMC Genomics. 12, 17 p., 225.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
32 Citations (Scopus)

Streptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium

Ferrando, M. L., Willemse, N., Zaccaria, E., Pannekoek, Y., van der Ende, A. & Schultsz, C., 2017, In : PLoS ONE. 12, 4, e0175639.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Streptococcus salivarius MS-oral-D6 promotes gingival re-epithelialization in vitro through a secreted serine protease

Fernandez Gutierrez, M., Roosjen, P. P. J., Ultee, E., Agelink, M., Vervoort, J. J. M., Keijser, B., Wells, J. M. & Kleerebezem, M., 2017, In : Scientific Reports. 7, 15 p., 11100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Stress physiology of lactic acid bacteria

Papadimitriou, K., Alegría, Á., Bron, P. A., De Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., Turroni, F., Van Sinderen, D., Varmanen, P., Ventura, M., Zúñiga, M., Tsakalidou, E. & Kok, J., 2016, In : Microbiology and Molecular Biology Reviews. 80, 3, p. 837-890

Research output: Contribution to journalArticleAcademicpeer-review

118 Citations (Scopus)

Structure dependent-immunomodulation by sugar beet arabinans via a SYK tyrosine kinase-dependent signaling pathway

Meijerink, M., Rösch, C., Taverne, N., Venema, K., Gruppen, H., Schols, H. A. & Wells, J. M., 12 Oct 2018, In : Frontiers in Immunology. 9, OCT, 1972.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

Rogier, R., Ederveen, T. H. A., Wopereis, H., Hartog, A., Boekhorst, J., Van Hijum, S. A. F. T., Knol, J., Garssen, J., Walgreen, B., Helsen, M. M., Van Der Kraan, P. M., Van Lent, P. L. E. M., Van De Loo, F. A. J., Abdollahi-Roodsaz, S. & Koenders, M. I., 8 Jul 2019, In : PLoS ONE. 14, 7, e0219366.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systems biology in animal sciences

Woelders, H., te Pas, M. F. W., Bannink, A., Veerkamp, R. F. & Smits, M. A., 2011, In : Animal. 5, 07, p. 1036-1047

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Tackling the chemical diversity of microbial nonulosonic acids-a universal large-scale survey approach

Kleikamp, H. B. C., Lin, Y. M., McMillan, D. G. G., Geelhoed, J. S., Naus-Wiezer, S. N. H., Van Baarlen, P., Saha, C., Louwen, R., Sorokin, D. Y., Van Loosdrecht, M. C. M. & Pabst, M., 21 Mar 2020, In : Chemical Science. 11, 11, p. 3074-3080 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice

El Aidy, S., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Samsom, J. N., Nieuwenhuis, E. E. S. & Kleerebezem, M., 2012, In : Mucosal Immunology. 5, p. 567-579

Research output: Contribution to journalArticleAcademicpeer-review

117 Citations (Scopus)

Temporal regulation of the transformasome and competence development in Streptococcus suis

Zaccaria, E., Wels, M., van Baarlen, P. & Wells, J. M., 2016, In : Frontiers in Microbiology. 7, 12 p., 1922.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

Baldry, M., Kitir, B., Frøkir, H., Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, H., Olsen, C. A., Wells, J. M. & Ingmer, H., 2016, In : PLoS ONE. 11, 1, 17 p., e0145618.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Elderman, M., Sovran, B., Hugenholtz, F., Graversen, K., Huijskes, M., Houtsma, E., Belzer, C., Boekschoten, M., de Vos, P., Dekker, J., Wells, J. & Faas, M. M., 2017, In : PLoS ONE. 12, 9, e0184274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)

The European LABDEL project and its relevance to the prevention and treatment of allergies

Daniel, C., Repa, A., Mercenier, A. M. E., Wiedermann, U. & Wells, J., 2007, In : Allergy. 62, 11, p. 1237-1242

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The gut microbiota and mucosal homeostasis: Colonized at birth or at adulthood, does it matter?

El-Aidy, S. F., Hooiveld, G. J. E. J., Tremaroli, V., Bäckhed, F. & Kleerebezem, M., 2013, In : Gut Microbes. 4, 2, p. 118-124

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation

El Aidy, S., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Holmes, E., Claus, S. P., Reijngoud, D. J. & Kleerebezem, M., 2013, In : Gut. 62, p. 1306-1314

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)

The Impact of Lactobacillus plantarum WCFS1 Teichoic Acid D-Alanylation on the Generation of Effector and Regulatory T-cells in Healthy Mice

Smelt, M. J., de Haan, B. J., Bron, P. A., van Swam, I., Meijerink, M., Wells, J., Kleerebezem, M., Faas, M. M. & de Vos, P., 2013, In : PLoS ONE. 8, 4, 14 p., e63099.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

The impact of probiotics and prebiotics on the immune system.

Klaenhammer, T. R., Kleerebezem, M., Kopp, M. V. & Rescigno, M., 2012, In : Nature Reviews. Immunology. 12, 10, p. 728-734

Research output: Contribution to journalArticleAcademicpeer-review

114 Citations (Scopus)

The major autolysin Acm2 from Lactobacillus plantarum undergoes cytoplasmic O-glycosylation

Fredriksen, L., Mathiesen, G., Moen, A., Bron, P. A., Kleerebezem, M., Eijsink, V. G. H. & Egge-Jacobsen, W., 2012, In : Journal of Bacteriology. 194, 2, p. 325-333

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
32 Citations (Scopus)

The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine.

El Aidy, S. F., Kunze, W., Bienenstock, J. & Kleerebezem, M., 2012, In : Beneficial Microbes. 3, 4, p. 251-259

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

The quest for probiotic effector molecules - Unraveling strain specificity at the molecular level

Lee, I. C., Tomita, S., Kleerebezem, M. & Bron, P. A., 2013, In : Pharmacological Research. 69, 1, p. 61-74

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

The response regulator YycF inhibits expression of the fatty acid biosynthesis repressor FabT in Streptococcus pneumoniae

Mohedano, M. L., Amblar, M., De La Fuente, A., Wells, J. M. & López, P., 2016, In : Frontiers in Microbiology. 7, 14 p., 1326.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria

Louwen, R., Staals, R. H. J., Endtz, H. P., van Baarlen, P. & van der Oost, J., 2014, In : Microbiology and Molecular Biology Reviews. 78, 1, p. 74-88

Research output: Contribution to journalArticleAcademicpeer-review

90 Citations (Scopus)