Research Output

Filter
Article
2016

Rationale and prospects of targeting bacterial two-component systems for antibacterial treatment of cystic fibrosis patients

Velikova, N. & Wells, J. M., 2016, In : Current Drug Targets. 17, 16

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Strain-specific features of extracellular polysaccharides and their impact on Lactobacillus plantarum-host interactions

Lee, I. C., Caggianiello, G., van Swam, I. I., Taverne, N., Meijerink, M., Bron, P. A., Spano, G. & Kleerebezem, M., 2016, In : Applied and Environmental Microbiology. 82, 13, p. 3959-3970

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
35 Citations (Scopus)

Stress physiology of lactic acid bacteria

Papadimitriou, K., Alegría, Á., Bron, P. A., De Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., Turroni, F., Van Sinderen, D., Varmanen, P., Ventura, M., Zúñiga, M., Tsakalidou, E. & Kok, J., 2016, In : Microbiology and Molecular Biology Reviews. 80, 3, p. 837-890

Research output: Contribution to journalArticleAcademicpeer-review

117 Citations (Scopus)

Temporal regulation of the transformasome and competence development in Streptococcus suis

Zaccaria, E., Wels, M., van Baarlen, P. & Wells, J. M., 2016, In : Frontiers in Microbiology. 7, 12 p., 1922.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

Baldry, M., Kitir, B., Frøkir, H., Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, H., Olsen, C. A., Wells, J. M. & Ingmer, H., 2016, In : PLoS ONE. 11, 1, 17 p., e0145618.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

The response regulator YycF inhibits expression of the fatty acid biosynthesis repressor FabT in Streptococcus pneumoniae

Mohedano, M. L., Amblar, M., De La Fuente, A., Wells, J. M. & López, P., 2016, In : Frontiers in Microbiology. 7, 14 p., 1326.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The Variable Regions of Lactobacillus rhamnosus Genomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires

Ceapa, C. D., Davids, M., Ritari, J., Lambert, J., Wels, M., Douillard, F. P., Smokvina, T., de Vos, W. M., Knol, J. & Kleerebezem, M., 20 May 2016, In : Genome Biology and Evolution. 8, 6, p. 1889-1905

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
19 Citations (Scopus)

Use of propidium monoazide for selective profiling of viable microbial cells during Gouda cheese ripening

Erkus, O., de Jager, V. C. L., Geene, R. T. C. M., van Alen-Boerrigter, I., Hazelwood, L., van Hijum, S. A. F. T., Kleerebezem, M. & Smid, E. J., 2016, In : International Journal of Food Microbiology. 228, p. 1-9

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2017

Amine Metabolism Is Influenced by Dietary Protein Source

Kar, S. K., Jansman, A. J. M., Schokker, D., Kruijt, L., Harms, A. C., Wells, J. M. & Smits, M. A., 1 Sep 2017, In : Frontiers in Nutrition. 4, 41.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles

Velikova, N., Mas, N., Miguel-Romero, L., Polo, L., Stolte, E., Zaccaria, E., Cao, R., Taverne, N., Murguía, J. R., Martinez-Manez, R., Marina, A. & Wells, J., 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 569-581

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Can probiotics modulate human disease by impacting intestinal barrier function?

Bron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L. & Wells, J. M., 2017, In : British Journal of Nutrition. 117, 1, p. 93-107

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
93 Citations (Scopus)

Cathelicidins inhibit Escherichia coli-induced TLR2 and TLR4 activation in a viability-dependent manner

Coorens, M., Schneider, V. A. F., De Groot, A. M., Van Dijk, A. I. J. M., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A. & Haagsman, H. P., 2017, In : The Journal of Immunology. 199, 4, p. 1418-1428

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

Dietary medium-chain saturated fatty acids induce gene expression of energy metabolism-related pathways in adipose tissue of abdominally obese subjects

Matualatupauw, J. C., Bohl, M., Gregersen, S., Hermansen, K. & Afman, L. A., 2017, In : International Journal of Obesity. 41, 9, p. 1348-1354

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Dietary protein sources differentially affect microbiota, mTOR activity and transcription of mTOR signaling pathways in the small intestine

Kar, S. K., Jansman, A. J. M., Benis, N., Ramiro-Garcia, J., Schokker, D., Kruijt, L., Stolte, E. H., Taverne-Thiele, J. J., Smits, M. A. & Wells, J. M., 1 Nov 2017, In : PLoS ONE. 12, 11, e0188282.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)
Open Access

Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet

Shi, W., Hegeman, M. A., van Dartel, D. A. M., Tang, J., Suarez, M., Swarts, H., van der Hee, B., Arola, L. & Keijer, J., 2017, In : Molecular Nutrition & Food Research. 61, 8, 1600878.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
21 Citations (Scopus)

Effects of in vitro fermentation of barley β-glucan and sugar beet pectin using human fecal inocula on cytokine expression by dendritic cells

Rosch, C., Taverne, N., Venema, K., Gruppen, H., Wells, J. M. & Schols, H. A., 2017, In : Molecular Nutrition & Food Research. 61, 1, 1600243.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Encapsulation of the therapeutic microbe Akkermansia muciniphila in a double emulsion enhances survival in simulated gastric conditions

van der Ark, K. C. H., Nugroho, A. D. W., Berton-Carabin, C., Wang, C., Belzer, C., de Vos, W. M. & Schroen, K., Dec 2017, In : Food Research International. 102, p. 372-379

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Feasibility of Metatranscriptome Analysis from Infant Gut Microbiota: Adaptation to Solid Foods Results in Increased Activity of Firmicutes at Six Months

Hugenholtz, F., Ritari, J., Nylund, L., Davids, M., Satokari, R. & De Vos, W. M., 2017, In : International Journal of Microbiology. 2017, 9547063.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Genome plasticity and polymorphisms in critical genes correlate with increased virulence of Dutch outbreak-related Coxiella burnetii strains

Kuley, R., Kuijt, E., Smits, M. A., Roest, H. I. J., Smith, H. E. & Bossers, A., 10 Aug 2017, In : Frontiers in Microbiology. 8, 1526.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., Derrien, M., Hugenholtz, F., Tang, L., Li, J., Zhang, J., Liu, C., Hao, Q., Vogel, U. B., Mortensen, A., Kleerebezem, M. & 8 others, Licht, T. R., Yang, H., Wang, J., Li, Y., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K., 2017, In : Microbiome. 5, p. 43

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
39 Citations (Scopus)

Homeostasis of the gut barrier and potential biomarkers

Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F., Cani, P. D., Theodorou, V., Dekker, J., Méheust, A., De Vos, W. M., Mercenier, A., Nauta, A. & Garcia-Rodenas, C. L., 2017, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 312, 3, p. G171-G193

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
88 Citations (Scopus)

Intestinal colonisation patterns in breastfed and formula-fed infants during the first 12 weeks of life reveal sequential microbiota signatures

Timmerman, H. M., Rutten, N. B. M. M., Boekhorst, J., Saulnier, D. M., Kortman, G. A. M., Contractor, N., Kullen, M., Floris, E., Harmsen, H. J. M., Vlieger, A. M., Kleerebezem, M. & Rijkers, G. T., 2017, In : Scientific Reports. 7, 8327.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Intestinal microbiome landscaping: Insight in community assemblage and implications for microbial modulation strategies

Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H. & de Vos, W. M., 2017, In : FEMS Microbiology Reviews. 41, 2, p. 182-199

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
37 Citations (Scopus)

Lactobacillus plantarum strains can enhance human mucosal and systemic immunity and prevent non-steroidal anti-inflammatory drug induced reduction in T regulatory Cells

de Vos, P., Mujagic, Z., de Haan, B. J., Siezen, R. J., Bron, P. A., Meijerink, M., Wells, J. M., Masclee, A. A. M., Boekschoten, M. V., Faas, M. M. & Troost, F. J., 2017, In : Frontiers in Immunology. 8, 18 p., 1000.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Metabolic in Vivo Labeling Highlights Differences of Metabolically Active Microbes from the Mucosal Gastrointestinal Microbiome between High-Fat and Normal Chow Diet

Oberbach, A., Haange, S. B., Schlichting, N., Heinrich, M., Lehmann, S., Till, H., Hugenholtz, F., Kullnick, Y., Smidt, H., Frank, K., Seifert, J., Jehmlich, N. & Von Bergen, M., 2017, In : Journal of Proteome Research. 16, 4, p. 1593-1604

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Multi-level integration of environmentally perturbed internal phenotypes reveals key points of connectivity between them

Benis, N., Kar, S. K., Martins dos Santos, V. A. P., Smits, M. A., Schokker, D. & Suarez-Diez, M., 2017, In : Frontiers in Physiology. 8, 11 p., 388.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

On the ecosystemic network of saliva in healthy young adults

Zaura, E., Brandt, B. W., Prodan, A., Teixeira De Mattos, M. J., Imangaliyev, S., Kool, J., Buijs, M. J., Jagers, F. L. P. W., Hennequin-Hoenderdos, N. L., Slot, D. E., Fernandez Gutierrez, M. & Kleerebezem, M., 1 May 2017, In : ISME Journal. 11, 5, p. 1218-1231

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
36 Citations (Scopus)

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

Ottman, N., Reunanen, J., Meijerink, M., Pietila, T. E., Kainulainen, V., Klievink, J., Huuskonen, L., Aalvink, S., Skurnik, M., Boeren, S., Satokari, R., Mercenier, A., Palva, A., Smidt, H., de Vos, W. M. & Belzer, C., 2017, In : PLoS ONE. 12, 3, e0173004.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
69 Citations (Scopus)

Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human colon

Chung, W. S. F., Meijerink, M., Zeuner, B., Holck, J., Louis, P., Meyer, A. S., Wells, J. M., Flint, H. J. & Duncan, S. H., 1 Nov 2017, In : FEMS microbiology ecology. 93, 11

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Streptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium

Ferrando, M. L., Willemse, N., Zaccaria, E., Pannekoek, Y., van der Ende, A. & Schultsz, C., 2017, In : PLoS ONE. 12, 4, e0175639.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Streptococcus salivarius MS-oral-D6 promotes gingival re-epithelialization in vitro through a secreted serine protease

Fernandez Gutierrez, M., Roosjen, P. P. J., Ultee, E., Agelink, M., Vervoort, J. J. M., Keijser, B., Wells, J. M. & Kleerebezem, M., 2017, In : Scientific Reports. 7, 15 p., 11100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Elderman, M., Sovran, B., Hugenholtz, F., Graversen, K., Huijskes, M., Houtsma, E., Belzer, C., Boekschoten, M., de Vos, P., Dekker, J., Wells, J. & Faas, M. M., 2017, In : PLoS ONE. 12, 9, e0184274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)

Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O. I. J., Vermeij, W., Brandt, R. M., Barnhoorn, R., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J., Hendriks, R. W. & Savelkoul, H. F. J., 2017, In : Journal of Leukocyte Biology. 101, 4, p. 811-821

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX

Mulder, J., Wels, M., Kuipers, O. P., Kleerebezem, M. & Bron, P. A., Oct 2017, In : Applied and Environmental Microbiology. 83, 20, 13 p., e01320-17.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Use of Microarray Datasets to generate Caco-2-dedicated Networks and to identify Reporter Genes of Specific Pathway Activity

Venkatasubramanian, P. B., Toydemir, G., de Wit, N., Saccenti, E., Martins dos Santos, V. A. P., van Baarlen, P., Wells, J. M., Suarez-Diez, M. & Mes, J. J., Jan 2017, In : Scientific Reports. 7, 1, 6778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
2018

An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment

Júnior, N. G. O., Cardoso, M. H., Cândido, E. S., van den Broek, D., de Lange, N., Velikova, N., Kleijn, J. M., Wells, J. M., Rezende, T. M. B., Franco, O. L. & de Vries, R., 24 Jul 2018, In : Scientific Reports. 8, 1, 11127.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Dietary diversity affects feeding behaviour of suckling piglets

Middelkoop, A., Choudhury, R., Gerrits, W. J. J., Kemp, B., Kleerebezem, M. & Bolhuis, J. E., Aug 2018, In : Applied Animal Behaviour Science. 205, p. 151-158

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Interactions of surface exopolysaccharides from bifidobacteriumand lactobacilluswithin the intestinal environment

Castro-Bravo, N., Wells, J. M., Margolles, A. & Ruas-Madiedo, P., 11 Oct 2018, In : Frontiers in Microbiology. 9, OCT, 2426.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)

Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

Bron, P. A. & Kleerebezem, M., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUG, 1821.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Metatranscriptome analysis of the microbial fermentation of dietary milk proteins in the murine gut

Hugenholtz, F., Davids, M., Schwarz, J., Müller, M., Tomé, D., Schaap, P., Hooiveld, G. J. E. J., Smidt, H. & Kleerebezem, M., 1 Apr 2018, In : PLoS ONE. 13, 4, e0194066.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Microbial metabolic gatekeeping in the jejunum

Kleerebezem, M., 1 Jun 2018, In : Nature Microbiology. 3, 6, p. 650-651

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Mouse models for human intestinal microbiota research: a critical evaluation

Hugenholtz, F. & de Vos, W. M., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 1, p. 149-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
59 Citations (Scopus)
Open Access
16 Citations (Scopus)

Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

van Splunter, M., van Hoffen, E., Floris-Vollenbroek, E. G., Timmerman, H., van de Bos, E. L., Meijer, B., Ulfman, L. H., Witteman, B., Wells, J. M., Brugman, S., Savelkoul, H. F. J. & van Neerven, R. J. J., 2018, In : Mucosal Immunology. 11, 4, p. 1254-1264

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Perspective: Fundamental limitations of the randomized controlled trial method in nutritional research: The example of probiotics

Zeilstra, D., Younes, J. A., Brummer, R. J. & Kleerebezem, M., Sep 2018, In : Advances in Nutrition. 9, 5, p. 561-571

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana

De Vries, S. P. W., Vurayai, M., Holmes, M., Gupta, S., Bateman, M., Goldfarb, D., Maskell, D. J., Matsheka, M. I. & Grant, A. J., 1 Mar 2018, In : PLoS ONE. 13, 3, e0194481.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double-blind, placebo-controlled, crossover trial

Esser, D., Geleijnse, J. M., Matualatupauw, J. C., Dower, J. I., Kromhout, D., Hollman, P. C. H. & Afman, L. A., 19 Apr 2018, In : PLoS ONE. 13, 4, 15 p., e0194229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Role of cell surface composition and lysis in static biofilm formation by Lactobacillus plantarum WCFS1

Fernández Ramírez, M. D., Nierop Groot, M. N., Smid, E. J., Hols, P., Kleerebezem, M. & Abee, T., 20 Apr 2018, In : International Journal of Food Microbiology. 271, p. 15-23

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Elderman, M., Hugenholtz, F., Belzer, C., Boekschoten, M., van Beek, A., de Haan, B., Savelkoul, H., de Vos, P. & Faas, M., 18 Jun 2018, In : Biology of Sex Differences. 9, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)