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2017

High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., Derrien, M., Hugenholtz, F., Tang, L., Li, J., Zhang, J., Liu, C., Hao, Q., Vogel, U. B., Mortensen, A., Kleerebezem, M. & 8 others, Licht, T. R., Yang, H., Wang, J., Li, Y., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K., 2017, In : Microbiome. 5, p. 43

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
39 Citations (Scopus)

Homeostasis of the gut barrier and potential biomarkers

Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F., Cani, P. D., Theodorou, V., Dekker, J., Méheust, A., De Vos, W. M., Mercenier, A., Nauta, A. & Garcia-Rodenas, C. L., 2017, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 312, 3, p. G171-G193

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
90 Citations (Scopus)

Intestinal colonisation patterns in breastfed and formula-fed infants during the first 12 weeks of life reveal sequential microbiota signatures

Timmerman, H. M., Rutten, N. B. M. M., Boekhorst, J., Saulnier, D. M., Kortman, G. A. M., Contractor, N., Kullen, M., Floris, E., Harmsen, H. J. M., Vlieger, A. M., Kleerebezem, M. & Rijkers, G. T., 2017, In : Scientific Reports. 7, 8327.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Intestinal microbiome landscaping: Insight in community assemblage and implications for microbial modulation strategies

Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H. & de Vos, W. M., 2017, In : FEMS Microbiology Reviews. 41, 2, p. 182-199

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
40 Citations (Scopus)

Lactobacillus plantarum strains can enhance human mucosal and systemic immunity and prevent non-steroidal anti-inflammatory drug induced reduction in T regulatory Cells

de Vos, P., Mujagic, Z., de Haan, B. J., Siezen, R. J., Bron, P. A., Meijerink, M., Wells, J. M., Masclee, A. A. M., Boekschoten, M. V., Faas, M. M. & Troost, F. J., 2017, In : Frontiers in Immunology. 8, 18 p., 1000.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Metabolic in Vivo Labeling Highlights Differences of Metabolically Active Microbes from the Mucosal Gastrointestinal Microbiome between High-Fat and Normal Chow Diet

Oberbach, A., Haange, S. B., Schlichting, N., Heinrich, M., Lehmann, S., Till, H., Hugenholtz, F., Kullnick, Y., Smidt, H., Frank, K., Seifert, J., Jehmlich, N. & Von Bergen, M., 2017, In : Journal of Proteome Research. 16, 4, p. 1593-1604

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Multi-level integration of environmentally perturbed internal phenotypes reveals key points of connectivity between them

Benis, N., Kar, S. K., Martins dos Santos, V. A. P., Smits, M. A., Schokker, D. & Suarez-Diez, M., 2017, In : Frontiers in Physiology. 8, 11 p., 388.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

On the ecosystemic network of saliva in healthy young adults

Zaura, E., Brandt, B. W., Prodan, A., Teixeira De Mattos, M. J., Imangaliyev, S., Kool, J., Buijs, M. J., Jagers, F. L. P. W., Hennequin-Hoenderdos, N. L., Slot, D. E., Fernandez Gutierrez, M. & Kleerebezem, M., 1 May 2017, In : ISME Journal. 11, 5, p. 1218-1231

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
36 Citations (Scopus)

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

Ottman, N., Reunanen, J., Meijerink, M., Pietila, T. E., Kainulainen, V., Klievink, J., Huuskonen, L., Aalvink, S., Skurnik, M., Boeren, S., Satokari, R., Mercenier, A., Palva, A., Smidt, H., de Vos, W. M. & Belzer, C., 2017, In : PLoS ONE. 12, 3, e0173004.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
70 Citations (Scopus)

Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human colon

Chung, W. S. F., Meijerink, M., Zeuner, B., Holck, J., Louis, P., Meyer, A. S., Wells, J. M., Flint, H. J. & Duncan, S. H., 1 Nov 2017, In : FEMS microbiology ecology. 93, 11

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Streptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epithelium

Ferrando, M. L., Willemse, N., Zaccaria, E., Pannekoek, Y., van der Ende, A. & Schultsz, C., 2017, In : PLoS ONE. 12, 4, e0175639.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Streptococcus salivarius MS-oral-D6 promotes gingival re-epithelialization in vitro through a secreted serine protease

Fernandez Gutierrez, M., Roosjen, P. P. J., Ultee, E., Agelink, M., Vervoort, J. J. M., Keijser, B., Wells, J. M. & Kleerebezem, M., 2017, In : Scientific Reports. 7, 15 p., 11100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Elderman, M., Sovran, B., Hugenholtz, F., Graversen, K., Huijskes, M., Houtsma, E., Belzer, C., Boekschoten, M., de Vos, P., Dekker, J., Wells, J. & Faas, M. M., 2017, In : PLoS ONE. 12, 9, e0184274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)

Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O. I. J., Vermeij, W., Brandt, R. M., Barnhoorn, R., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J., Hendriks, R. W. & Savelkoul, H. F. J., 2017, In : Journal of Leukocyte Biology. 101, 4, p. 811-821

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX

Mulder, J., Wels, M., Kuipers, O. P., Kleerebezem, M. & Bron, P. A., Oct 2017, In : Applied and Environmental Microbiology. 83, 20, 13 p., e01320-17.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Use of Microarray Datasets to generate Caco-2-dedicated Networks and to identify Reporter Genes of Specific Pathway Activity

Venkatasubramanian, P. B., Toydemir, G., de Wit, N., Saccenti, E., Martins dos Santos, V. A. P., van Baarlen, P., Wells, J. M., Suarez-Diez, M. & Mes, J. J., Jan 2017, In : Scientific Reports. 7, 1, 6778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
2016

A zebrafish larval model to assess virulence of porcine streptococcus suis strains

Zaccaria, E., Cao, R., Wells, J. M. & Van Baarlen, P., 2016, In : PLoS ONE. 11, 3, e0151623.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Characterization of the transcriptional regulation of the tariJKL locus involved in ribitol-containing wall teichoic acid biosynthesis in Lactobacillus plantarum

Tomita, S., Lee, I. C., van Swam, I. I., Boeren, S., Vervoort, J., Bron, P. A. & Kleerebezem, M., 1 Feb 2016, In : Microbiology. 162, 2, p. 420-432 000229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Complete genome sequence of Streptococcus salivarius HSISS4, a human commensal bacterium highly prevalent in the digestive tract

Mignolet, J., Fontaine, L., Kleerebezem, M. & Hols, P., 2016, In : Genome Announcements. 4, 1, e01637-15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Draft Genome Sequence of Lactobacillus plantarum SF2A35B

Bron, P. A., Lee, I. C., Backus, L., Van Hijum, S. A. F. T., Wels, M. & Kleerebezem, M., 2016, In : Genome Announcements. 4, 1, e01638-15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice

Kiilerich, P., Myrmel, L. S., Fjære, E., Hao, Q., Hugenholtz, F., Sonne, S. B., Derrien, M., Pedersen, L. M., Petersen, R. K., Mortensen, A., Licht, T. R., Rømer, M. U., Vogel, U. B., Waagbø, L. J., Giallourou, N., Feng, Q., Xiao, L., Liu, C., Liaset, B., Kleerebezem, M. & 3 others, Wang, J., Madsen, L. & Kristiansen, K., 2016, In : American Journal of Physiology. Endocrinology and Metabolism. 310, 11, p. E886-E899

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Effects of digested onion extracts on intestinal gene expression: an interspecies comparison using different intestine models

de Wit, N. J. W., Hulst, M. M., Govers, C. C. F. M., van der Meulen, J., van Hoef, A. M. A., Stoopen, G. M., Hamers, A. R. M., Hoekman, A. J. W., de Vos, C. H., Bovee, T. F. H., Smits, M. A., Mes, J. J. & Hendriksen, P. J. M., 15 Sep 2016, In : PLoS ONE. 11, 9, 18 p., e0160719.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis

Velikova, N., Kavanagh, K. & Wells, J. M., 2016, In : BMC Microbiology. 16, 1, 9 p., 291.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Exopolysaccharides produced by lactic acid bacteria: from health-promoting benefits to stress tolerance mechanisms

Caggianiello, G., Kleerebezem, M. & Spano, G., 2016, In : Applied Microbiology and Biotechnology. 100, 9, p. 3877-3886

Research output: Contribution to journalArticleAcademicpeer-review

112 Citations (Scopus)

Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses

Rossi, O., Van Berkel, L. A., Chain, F., Tanweer Khan, M., Taverne, N., Sokol, H., Duncan, S. H., Flint, H. J., Harmsen, H. J. M., Langella, P., Samsom, J. N. & Wells, J. M., 2016, In : Scientific Reports. 6, 12 p., 18507.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
67 Citations (Scopus)

First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937

Kuley, R., Smith, H. E., Janse, I., Harders, F. L., Baas, F., Schijlen, E., Nabuurs-Fransen, M. H., Smits, M. A., Roest, H. I. J. & Bossers, A., 2016, In : Genome Announcements. 4, 2, 2 p., e00245-16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Functional Profiling of Unfamiliar Microbial Communities Using a Validated De Novo Assembly Metatranscriptome Pipeline

Davids, M., Hugenholtz, F., Martins dos Santos, V. A. P., Smidt, H., Kleerebezem, M. & Schaap, P. J., 2016, In : PLoS ONE. 11, 1, 18 p., e0146423.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Human intestinal barrier function in health and disease

König, J., Wells, J., Cani, P. D., García-Ródenas, C. L., MacDonald, T., Mercenier, A., Whyte, J., Troost, F. J. & Brummer, R-J., 2016, In : Clinical and Translational Gastroenterology. 7, 10, e196.

Research output: Contribution to journalArticleAcademicpeer-review

183 Citations (Scopus)

Human oral isolate Lactobacillus fermentum AGR1487 induces a pro-inflammatory response in germ-free rat colons

Anderson, R. C., Ulluwishewa, D., Young, W., Ryan, L. J., Henderson, G., Meijerink, M., Maier, E., Wells, J. M. & Roy, N. C., 2016, In : Scientific Reports. 6, 20318.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Identification of commensal species positively correlated with early stress responses to a compromised mucus barrier

Sovran, B., Lu, P., Loonen, L. M. P., Hugenholtz, F., Belzer, C., Stolte, E. H., Boekschoten, M. V., Van Baarlen, P., Smidt, H., Kleerebezem, M., De Vos, P., Renes, I. B., Wells, J. M. & Dekker, J., 2016, In : Inflammatory Bowel Diseases. 22, 4, p. 826-840

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Immunomodulatory properties of oat and barley β-glucan populations on bone marrow derived dendritic cells

Rosch, C., Meijerink, M., Delahaije, R. J. B. M., Taverne, N., Gruppen, H., Wells, J. M. & Schols, H. A., 2016, In : Journal of Functional Foods. 26, p. 279-289

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Increased fat and polyunsaturated fatty acid content in sow gestation diet has no effect on gene expression in progeny during the first 7 days of life

de Greeff, A., Bikker, P., Smit-Heinsbroek, A., Bruininx, E., Zwolschen, H., Fijten, H. P. D., Zetteler, P., Vastenhouw, S. A., Smits, M. A. & Rebel, J. M. J., 2016, In : Journal of Animal Physiology and Animal Nutrition. 100, 1, p. 127-135

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Metabolic Context of the Competence-Induced Checkpoint for Cell Replication in Streptococcus suis

Zaccaria, E., Wells, J. M. & van Baarlen, P., 2016, In : PLoS ONE. 11, 5, e0153571.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Nomadic lifestyle of Lactobacillus plantarum revealed by comparative genomics of 54 strains isolated from different habitats

Martino, M. E., Bayjanov, J. R., Caffrey, B. E., Wels, M., Joncour, P., Hughes, S., Gillet, B., Kleerebezem, M., van Hijum, S. A. F. T. & Leulier, F., 2016, In : Environmental Microbiology. 18, 12, p. 4974-4989

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
43 Citations (Scopus)

Plasmid Complement of Lactococcus lactis NCDO712 Reveals a Novel Pilus Gene Cluster

Tarazanova, M., Beerthuyzen, M., Siezen, R., Fernandez Gutierrez, M., de Jong, A., van der Meulen, S., Kok, J. & Bachmann, H., 2016, In : PLoS ONE. 11, 12, e0167970.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Protein, peptide, amino acid composition, and potential functional properties of existing and novel dietary protein sources for monogastrics

Kar, S. K., Jansman, A. J. M., Boeren, S., Kruijt, L. & Smits, M. A., 2016, In : Journal of Animal Science. 94, 7 supplement 3, p. 30-39

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

Velikova, N., Fulle, S., Manso, A. S., Mechkarska, M., Finn, P., Conlon, J. M., Oggioni, M. R., Wells, J. M. & Marina, A., 13 May 2016, In : Scientific Reports. 6, 26085.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Rationale and prospects of targeting bacterial two-component systems for antibacterial treatment of cystic fibrosis patients

Velikova, N. & Wells, J. M., 2016, In : Current Drug Targets. 17, 16

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Strain-specific features of extracellular polysaccharides and their impact on Lactobacillus plantarum-host interactions

Lee, I. C., Caggianiello, G., van Swam, I. I., Taverne, N., Meijerink, M., Bron, P. A., Spano, G. & Kleerebezem, M., 2016, In : Applied and Environmental Microbiology. 82, 13, p. 3959-3970

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
35 Citations (Scopus)

Stress physiology of lactic acid bacteria

Papadimitriou, K., Alegría, Á., Bron, P. A., De Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., Turroni, F., Van Sinderen, D., Varmanen, P., Ventura, M., Zúñiga, M., Tsakalidou, E. & Kok, J., 2016, In : Microbiology and Molecular Biology Reviews. 80, 3, p. 837-890

Research output: Contribution to journalArticleAcademicpeer-review

118 Citations (Scopus)

Temporal regulation of the transformasome and competence development in Streptococcus suis

Zaccaria, E., Wels, M., van Baarlen, P. & Wells, J. M., 2016, In : Frontiers in Microbiology. 7, 12 p., 1922.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

Baldry, M., Kitir, B., Frøkir, H., Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, H., Olsen, C. A., Wells, J. M. & Ingmer, H., 2016, In : PLoS ONE. 11, 1, 17 p., e0145618.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

The response regulator YycF inhibits expression of the fatty acid biosynthesis repressor FabT in Streptococcus pneumoniae

Mohedano, M. L., Amblar, M., De La Fuente, A., Wells, J. M. & López, P., 2016, In : Frontiers in Microbiology. 7, 14 p., 1326.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The Variable Regions of Lactobacillus rhamnosus Genomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires

Ceapa, C. D., Davids, M., Ritari, J., Lambert, J., Wels, M., Douillard, F. P., Smokvina, T., de Vos, W. M., Knol, J. & Kleerebezem, M., 20 May 2016, In : Genome Biology and Evolution. 8, 6, p. 1889-1905

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
19 Citations (Scopus)

Use of propidium monoazide for selective profiling of viable microbial cells during Gouda cheese ripening

Erkus, O., de Jager, V. C. L., Geene, R. T. C. M., van Alen-Boerrigter, I., Hazelwood, L., van Hijum, S. A. F. T., Kleerebezem, M. & Smid, E. J., 2016, In : International Journal of Food Microbiology. 228, p. 1-9

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2015

Activation of the chicken type I IFN response by infectious bronchitis coronavirus

Kint, J., Fernandez Gutierrez, M. M., Maier, H. J., Britton, P., Langereis, M. A., Koumans, J., Wiegertjes, G. F. & Forlenza, M., 2015, In : Journal of Virology. 89, 2, p. 1156-1167

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
41 Citations (Scopus)

Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

Bem, A. E., Velikova, N. R., Pellicer, M. T., van Baarlen, P., Marina, A. & Wells, J. M., 2015, In : Acs Chemical Biology. 10, 1, p. 213-224

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)

Cell-Free Propagation of Coxiella burnetii Does Not Affect Its Relative Virulence

Kuley, R., Smith, H. E., Frangoulidis, D., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : PLoS ONE. 10, 3, 16 p., e0121661.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Construction and validation of a mCherry protein vector for promoter analysis in Lactobacillus acidophilus

Mohedano, M. L., Garcia-Cayuela, T., Perez-Ramos, A., Gaiser, R. A., Requena, T. & Lopez, P., 2015, In : Journal of Industrial Microbiology and Biotechnology. 42, 2, p. 247-253

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Correlation of Lactobacillus rhamnosus genotypes and carbohydrate utilization signatures determined by phenotype profiling

Ceapa, C., Lambert, J., van Limpt, K., Wels, M., Smokvina, T., Knol, J. & Kleerebezem, M., 2015, In : Applied and Environmental Microbiology. 81, 16, p. 5458-5470

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)