Research Output 2005 2019

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2019
7 Citations (Scopus)

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M., Van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., De Vos, P., Dekker, J. & Wells, J. M., 5 Feb 2019, In : Scientific Reports. 9, 1, 1437.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Mucus
Immunity
Paneth Cells
T-Lymphocytes
3 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mucus
B-Lymphocytes
B-Lymphoid Precursor Cells
Transcriptome
Anti-Inflammatory Agents
Open Access
Attention Deficit Disorder with Hyperactivity
Biomarkers
Diet
Food
Research

Draft Genome Sequence of Streptococcus suis S10, a Virulent Strain Used in Experimental Pig Infections

Gaiser, R. A., Zomer, A. L., Wells, J. M. & van Baarlen, P., 6 Jun 2019, In : Microbiology Resource Announcements. 8, 23, 3 p., e00227-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Streptococcus suis
S 10
Swine
Genome
Prophages
1 Citation (Scopus)

Evaluating single-particle tracking by photo-activation localization microscopy (sptPALM) in Lactococcus lactis

van Beljouw, S. P. B., van der Els, S., Martens, K. J. A., Kleerebezem, M., Bron, P. A. & Hohlbein, J., 8 Mar 2019, In : Physical Biology. 16, 3, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lactococcus lactis
Microscopy
CRISPR-Cas Systems
Fermentation
Lactic Acid
1 Citation (Scopus)

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells

Castro-Bravo, N., Margolles, A., Wells, J. M. & Ruas-Madiedo, P., 1 Apr 2019, In : Anaerobe. 56, p. 98-101 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Toll-Like Receptors
Epithelial Cells
Kidney
Bifidobacterium animalis

High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis

Benis, N., Wells, J. M., Smits, M. A., Kar, S. K., Van Der Hee, B., Martins Dos Santos, V. A. P., Suarez-Diez, M. & Schokker, D., 30 Dec 2019, In : BMC Genomics. 20, 1, 1028.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Homeostasis
Intestinal Mucosa
Organoids
Intestines
Maintenance

Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression

Matualatupauw, J. C., O'Grada, C., Hughes, M. F., Roche, H. M., Afman, L. A. & Bouwman, J., 1 Oct 2019, In : Molecular Nutrition and Food Research. 63, 20, 1900101.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
blood cells
Blood Cells
Fats
Genome
Gene Expression
2 Citations (Scopus)

In vivo transcriptomes of Streptococcus suis reveal genes required for niche-specific adaptation and pathogenesis

Arenas, J., Bossers-de Vries, R., Harders-Westerveen, J., Buys, H., Ruuls-van Stalle, L. M. F., Stockhofe-Zurwieden, N., Zaccaria, E., Tommassen, J., Wells, J. M., Smith, H. E. & de Greeff, A., 7 Apr 2019, In : Virulence. 10, 1, p. 334-351

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Streptococcus suis
Transcriptome
Virulence Factors
Genes
Swine
3 Citations (Scopus)

Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe

Ryan, P. M., Stolte, E. H., London, L. E. E., Wells, J. M., Long, S. L., Joyce, S. A., Gahan, C. G. M., Fitzgerald, G. F., Ross, R. P., Caplice, N. M. & Stanton, C., 8 Feb 2019, In : BMC Microbiology. 19, 1, 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
choloylglycine hydrolase
Lactobacillus
Bile
Mucous Membrane
Lactobacillus reuteri
Open Access
Microbiota
Feces
Fusobacteria
Swine
Bacteroidetes

Microbial communities in a dynamic in vitro model for the human ileum resemble the human ileal microbiota

Stolaki, M., Minekus, M., Venema, K., Lahti, L., Smid, E. J., Kleerebezem, M. & Zoetendal, E. G., 1 Aug 2019, In : FEMS microbiology ecology. 95, 8, fiz096.

Research output: Contribution to journalArticleAcademicpeer-review

Microbiota
Ileum
Ileostomy
microbial community
effluent
Open Access
Streptococcus suis
Wales
Zoonoses
Genetic Markers
England
7 Citations (Scopus)

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation

Koper, J. E. B., Loonen, L. M. P., Wells, J. M., Troise, A. D., Capuano, E. & Fogliano, V., 1 Feb 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800722.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Luteolin
Aryl Hydrocarbon Receptors
Polyphenols
luteolin
Tryptophan
3 Citations (Scopus)

Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

Bron, P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska, L. P., Kuipers, O. P., Kok, J. & Kleerebezem, M., 1 Apr 2019, In : Current Opinion in Biotechnology. 56, p. 61-68 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lactic acid
Lactic Acid
Bacteria
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
Open Access
Volatile Fatty Acids
Microbiota
Oligosaccharides
Human Milk
Prebiotics

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

Rogier, R., Ederveen, T. H. A., Wopereis, H., Hartog, A., Boekhorst, J., Van Hijum, S. A. F. T., Knol, J., Garssen, J., Walgreen, B., Helsen, M. M., Van Der Kraan, P. M., Van Lent, P. L. E. M., Van De Loo, F. A. J., Abdollahi-Roodsaz, S. & Koenders, M. I., 8 Jul 2019, In : PLoS ONE. 14, 7, e0219366.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
galactooligosaccharides
Interleukin-1 Receptors
fructooligosaccharides
interleukin-1
arthritis
8 Citations (Scopus)

Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics

Kleerebezem, M., Binda, S., Bron, P. A., Gross, G., Hill, C., van Hylckama Vlieg, J. E. T., Lebeer, S., Satokari, R. & Ouwehand, A. C., 1 Apr 2019, In : Current Opinion in Biotechnology. 56, p. 55-60

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Probiotics
Insurance Benefits
Pipelines
Health
Clinical Trials
2 Citations (Scopus)

Visualisation of dCas9 target search in vivo using an open-microscopy framework

Martens, K. J. A., van Beljouw, S. P. B., van der Els, S., Vink, J. N. A., Baas, S., Vogelaar, G. A., Brouns, S. J. J., van Baarlen, P., Kleerebezem, M. & Hohlbein, J., 7 Aug 2019, In : Nature Communications. 10, 1, 3552.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Microscopy
Microscopic examination
Screening
Plasmids
2018
1 Citation (Scopus)

An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment

Júnior, N. G. O., Cardoso, M. H., Cândido, E. S., van den Broek, D., de Lange, N., Velikova, N., Kleijn, J. M., Wells, J. M., Rezende, T. M. B., Franco, O. L. & de Vries, R., 24 Jul 2018, In : Scientific Reports. 8, 1, 11127.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Peptides
Membranes
Crotalid Venoms
Acidic Amino Acids
Peptide Fragments
5 Citations (Scopus)

Dietary diversity affects feeding behaviour of suckling piglets

Middelkoop, A., Choudhury, R., Gerrits, W. J. J., Kemp, B., Kleerebezem, M. & Bolhuis, J. E., Aug 2018, In : Applied Animal Behaviour Science. 205, p. 151-158

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Feeding Behavior
Weaning
suckling
feeding behavior
piglets
18 Citations (Scopus)

Interactions of surface exopolysaccharides from bifidobacteriumand lactobacilluswithin the intestinal environment

Castro-Bravo, N., Wells, J. M., Margolles, A. & Ruas-Madiedo, P., 11 Oct 2018, In : Frontiers in Microbiology. 9, OCT, 2426.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Probiotics
Bifidobacterium
Bacteria
Carbohydrates
Lactobacillus
6 Citations (Scopus)

Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

Bron, P. A. & Kleerebezem, M., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUG, 1821.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactic Acid
Bacteria
Health
Lactococcus
Genetic Engineering
1 Citation (Scopus)

Metatranscriptome analysis of the microbial fermentation of dietary milk proteins in the murine gut

Hugenholtz, F., Davids, M., Schwarz, J., Müller, M., Tomé, D., Schaap, P., Hooiveld, G. J. E. J., Smidt, H. & Kleerebezem, M., 1 Apr 2018, In : PLoS ONE. 13, 4, e0194066.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dietary Proteins
Milk Proteins
milk proteins
short chain fatty acids
Fermentation
2 Citations (Scopus)

Microbial metabolic gatekeeping in the jejunum

Kleerebezem, M., 1 Jun 2018, In : Nature Microbiology. 3, 6, p. 650-651

Research output: Contribution to journalArticleAcademicpeer-review

Gatekeeping
Overnutrition
Microbiota
Jejunum
Malnutrition
49 Citations (Scopus)

Mouse models for human intestinal microbiota research: a critical evaluation

Hugenholtz, F. & de Vos, W. M., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 1, p. 149-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Research
Microbiota
Comparative Physiology
Bacterial Genes
Metagenomics
15 Citations (Scopus)
Open Access
Organoids
Swine
Stem Cells
Paneth Cells
Tight Junctions
3 Citations (Scopus)

Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

van Splunter, M., van Hoffen, E., Floris-Vollenbroek, E. G., Timmerman, H., van de Bos, E. L., Meijer, B., Ulfman, L. H., Witteman, B., Wells, J. M., Brugman, S., Savelkoul, H. F. J. & van Neerven, R. J. J., 2018, In : Mucosal Immunology. 11, 4, p. 1254-1264

Research output: Contribution to journalArticleAcademicpeer-review

Cholera
Large Intestine
Respiratory System
Immunoglobulin A
Vaccination
9 Citations (Scopus)

Perspective: Fundamental limitations of the randomized controlled trial method in nutritional research: The example of probiotics

Zeilstra, D., Younes, J. A., Brummer, R. J. & Kleerebezem, M., Sep 2018, In : Advances in Nutrition. 9, 5, p. 561-571

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Probiotics
probiotics
Randomized Controlled Trials
Research
methodology
6 Citations (Scopus)

Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana

De Vries, S. P. W., Vurayai, M., Holmes, M., Gupta, S., Bateman, M., Goldfarb, D., Maskell, D. J., Matsheka, M. I. & Grant, A. J., 1 Mar 2018, In : PLoS ONE. 13, 3, e0194481.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Botswana
Poultry
Campylobacter
antibiotic resistance
Chickens
3 Citations (Scopus)

Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double-blind, placebo-controlled, crossover trial

Esser, D., Geleijnse, J. M., Matualatupauw, J. C., Dower, J. I., Kromhout, D., Hollman, P. C. H. & Afman, L. A., 19 Apr 2018, In : PLoS ONE. 13, 4, 15 p., e0194229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Catechin
Blood pressure
epicatechin
Transcriptome
Flavonoids
3 Citations (Scopus)

Role of cell surface composition and lysis in static biofilm formation by Lactobacillus plantarum WCFS1

Fernández Ramírez, M. D., Nierop Groot, M. N., Smid, E. J., Hols, P., Kleerebezem, M. & Abee, T., 20 Apr 2018, In : International Journal of Food Microbiology. 271, p. 15-23

Research output: Contribution to journalArticleAcademicpeer-review

Lactobacillus plantarum
Biofilms
biofilm
mutants
Gentian Violet
12 Citations (Scopus)

Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Elderman, M., Hugenholtz, F., Belzer, C., Boekschoten, M., van Beek, A., de Haan, B., Savelkoul, H., de Vos, P. & Faas, M., 18 Jun 2018, In : Biology of Sex Differences. 9, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Allergy and Immunology
Sex Characteristics
Disease
Clostridium
8 Citations (Scopus)

Sex differences in lipid metabolism are affected by presence of the gut microbiota

Baars, A., Oosting, A., Lohuis, M., Koehorst, M., El Aidy, S., Hugenholtz, F., Smidt, H., Mischke, M., Boekschoten, M. V., Verkade, H. J., Garssen, J., van der Beek, E. M., Knol, J., de Vos, P., van Bergenhenegouwen, J. & Fransen, F., 1 Sep 2018, In : Scientific Reports. 8, 1, 13426.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Sex Characteristics
Microbiota
Bile Acids and Salts
Physiological Phenomena
4 Citations (Scopus)

Structure dependent-immunomodulation by sugar beet arabinans via a SYK tyrosine kinase-dependent signaling pathway

Meijerink, M., Rösch, C., Taverne, N., Venema, K., Gruppen, H., Schols, H. A. & Wells, J. M., 12 Oct 2018, In : Frontiers in Immunology. 9, OCT, 1972.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Beta vulgaris
Immunomodulation
Dietary Fiber
Dendritic Cells
Bone Marrow
14 Citations (Scopus)

Versatile Cas9-driven subpopulation selection toolbox for Lactococcus lactis

van der Els, S., James, J. K., Kleerebezem, M. & Bron, P. A., 1 Apr 2018, In : Applied and Environmental Microbiology. 84, 8, e02752-17.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactococcus lactis
subpopulation
chemical derivatives
plasmid
targeting
2017

Amine Metabolism Is Influenced by Dietary Protein Source

Kar, S. K., Jansman, A. J. M., Schokker, D., Kruijt, L., Harms, A. C., Wells, J. M. & Smits, M. A., 1 Sep 2017, In : Frontiers in Nutrition. 4, 41.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
amines
protein sources
dietary protein
blood serum
metabolism
6 Citations (Scopus)

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles

Velikova, N., Mas, N., Miguel-Romero, L., Polo, L., Stolte, E., Zaccaria, E., Cao, R., Taverne, N., Murguía, J. R., Martinez-Manez, R., Marina, A. & Wells, J., 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 569-581

Research output: Contribution to journalArticleAcademicpeer-review

Histidine
Silicon Dioxide
Nanoparticles
Lysine
Phosphotransferases
82 Citations (Scopus)

Can probiotics modulate human disease by impacting intestinal barrier function?

Bron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L. & Wells, J. M., 2017, In : British Journal of Nutrition. 117, 1, p. 93-107

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Intestinal Diseases
Probiotics
Gastrointestinal Diseases
Homeostasis
Necrotizing Enterocolitis
13 Citations (Scopus)

Cathelicidins inhibit Escherichia coli-induced TLR2 and TLR4 activation in a viability-dependent manner

Coorens, M., Schneider, V. A. F., De Groot, A. M., Van Dijk, A. I. J. M., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A. & Haagsman, H. P., 2017, In : The Journal of Immunology. 199, 4, p. 1418-1428

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cathelicidins
Escherichia coli
Inflammation
Bacteria
Immune System
6 Citations (Scopus)

Dietary medium-chain saturated fatty acids induce gene expression of energy metabolism-related pathways in adipose tissue of abdominally obese subjects

Matualatupauw, J. C., Bohl, M., Gregersen, S., Hermansen, K. & Afman, L. A., 2017, In : International Journal of Obesity. 41, 9, p. 1348-1354

Research output: Contribution to journalArticleAcademicpeer-review

Energy Metabolism
Adipose Tissue
Fatty Acids
Gene Expression
Caseins
6 Citations (Scopus)

Dietary protein sources differentially affect microbiota, mTOR activity and transcription of mTOR signaling pathways in the small intestine

Kar, S. K., Jansman, A. J. M., Benis, N., Ramiro-Garcia, J., Schokker, D., Kruijt, L., Stolte, E. H., Taverne-Thiele, J. J., Smits, M. A. & Wells, J. M., 1 Nov 2017, In : PLoS ONE. 12, 11, e0188282.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dietary Proteins
Microbiota
Sirolimus
Transcription
Nutrition
Open Access
Peptide Synthases
Valinomycin
Ionophores
Swine
Genome
20 Citations (Scopus)

Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet

Shi, W., Hegeman, M. A., van Dartel, D. A. M., Tang, J., Suarez, M., Swarts, H., van der Hee, B., Arola, L. & Keijer, J., 2017, In : Molecular Nutrition & Food Research. 61, 8, 1600878.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
White Adipose Tissue
nicotinamide
white adipose tissue
beta oxidation
Diet
1 Citation (Scopus)
Beta vulgaris
Glucans
glucans
Hordeum
dendritic cells
9 Citations (Scopus)

Encapsulation of the therapeutic microbe Akkermansia muciniphila in a double emulsion enhances survival in simulated gastric conditions

van der Ark, K. C. H., Nugroho, A. D. W., Berton-Carabin, C., Wang, C., Belzer, C., de Vos, W. M. & Schroen, K., Dec 2017, In : Food Research International. 102, p. 372-379

Research output: Contribution to journalArticleAcademicpeer-review

encapsulation
Emulsions
emulsions
Stomach
stomach
3 Citations (Scopus)

Feasibility of Metatranscriptome Analysis from Infant Gut Microbiota: Adaptation to Solid Foods Results in Increased Activity of Firmicutes at Six Months

Hugenholtz, F., Ritari, J., Nylund, L., Davids, M., Satokari, R. & De Vos, W. M., 2017, In : International Journal of Microbiology. 2017, 9547063.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactobacillus rhamnosus
Bifidobacterium
Actinobacteria
Food
Messenger RNA
5 Citations (Scopus)

Genome plasticity and polymorphisms in critical genes correlate with increased virulence of Dutch outbreak-related Coxiella burnetii strains

Kuley, R., Kuijt, E., Smits, M. A., Roest, H. I. J., Smith, H. E. & Bossers, A., 10 Aug 2017, In : Frontiers in Microbiology. 8, 1526.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Coxiella burnetii
Disease Outbreaks
Virulence
Genome
Genotype
34 Citations (Scopus)

High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., Derrien, M., Hugenholtz, F., Tang, L., Li, J., Zhang, J., Liu, C., Hao, Q., Vogel, U. B., Mortensen, A., Kleerebezem, M. & 8 others, Licht, T. R., Yang, H., Wang, J., Li, Y., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K., 2017, In : Microbiome. 5, p. 43

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Obesity
Fats
High Fat Diet
Butyrates
Obese Mice
73 Citations (Scopus)

Homeostasis of the gut barrier and potential biomarkers

Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F., Cani, P. D., Theodorou, V., Dekker, J., Méheust, A., De Vos, W. M., Mercenier, A., Nauta, A. & Garcia-Rodenas, C. L., 2017, In : American Journal of Physiology. Gastrointestinal and Liver Physiology. 312, 3, p. G171-G193

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Secretory Immunoglobulin A
Microbiota
Mucus
proctolin
Mast Cells