Research Output

2020

A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility

Fernandez-Gutierrez, M. M., Imangaliyev, S., Prodan, A., Loos, B. G., Keijser, B. J. F. & Kleerebezem, M., 20 Feb 2020, In : Scientific Reports. 10, 1, 3008.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Identification and characterization of genes contributing to the virulence of the major swine pathogen Streptococcus suis

Gussak, A., Ferrando, M. L., Murray, G., Hossain, M., Weinert, L., van Baarlen, P. & Wells, J. M., 14 Feb 2020, Wias Annual Conference 2020: Frontiers in Animal Sciences. WIAS, p. 52-52

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

Immune regulation by human colonic bacteria and short-chain fatty acids

Winaris, N., 2020, Wageningen: Wageningen University. 211 p.

Research output: Thesisinternal PhD, WU

In-depth cultivation and characterisation of the pig tonsil microbiome: towards targeted approaches for microbiome manipulation

Fernandes de Oliveira, I., Fernandez Gutierrez, M. M., van Baarlen, P. & Wells, J. M., 14 Feb 2020, WIAS Annual Conference 2020: Frontiers in Animal Sciences. WIAS, p. 24-24

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

Organoid Models and Genome Editing to Investigate Fucosylation of Epithelial Receptors and Disease Resistance in Pigs

Ritchie Martinez, A., 24 Feb 2020, Wias Annual Conference 2020: Frontiers in Animal Sciences. WIAS, p. 55-55

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access
Open Access

Tackling the chemical diversity of microbial nonulosonic acids-a universal large-scale survey approach

Kleikamp, H. B. C., Lin, Y. M., McMillan, D. G. G., Geelhoed, J. S., Naus-Wiezer, S. N. H., Van Baarlen, P., Saha, C., Louwen, R., Sorokin, D. Y., Van Loosdrecht, M. C. M. & Pabst, M., 21 Mar 2020, In : Chemical Science. 11, 11, p. 3074-3080 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The gut way to health: In vitro studies on immunomodulatory food compounds

Koper, J., 2020, Wageningen: Wageningen University. 165 p.

Research output: Thesisinternal PhD, WU

Open Access

The tonsillar microbiome of Streptococcus suis diseased piglets

Fredriksen, S., Neila, C., Fernandes de Oliveira, I., Murray, G., Guan, X., Ferrando, M. L., Correa-Fiz, F., van Baarlen, P., Aragon, V. & Wells, J. M., 14 Feb 2020, WIAS Annual Conference 2020: Frontiers in Animal Sciences. WIAS, p. 22-22

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access
2019

0046 - Organoids as models to study probiotics

van der Hee, B., Loonen, L. M. P., Taverne, N., Taverne-Thiele, J. J., Smidt, H. & Wells, J. M., 19 Jun 2019, p. 57. 1 p.

Research output: Contribution to conferenceAbstract

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M., Van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., De Vos, P., Dekker, J. & Wells, J. M., 5 Feb 2019, In : Scientific Reports. 9, 1, 1437.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)
Open Access
1 Citation (Scopus)

Corrigendum: Sialyllactose and Galactooligosaccharides Promote Epithelial Barrier Functioning and Distinctly Modulate Microbiota Composition and Short Chain Fatty Acid Production In Vitro

Perdijk, O., van Baarlen, P., Fernandez-Gutierrez, M. M., van den Brink, E., Schuren, F. H. J., Brugman, S., Savelkoul, H. F. J., Kleerebezem, M. & van Neerven, R. J. J., 10 Apr 2019, In : Frontiers in Immunology. 10, 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access
1 Citation (Scopus)

Draft Genome Sequence of Streptococcus suis S10, a Virulent Strain Used in Experimental Pig Infections

Gaiser, R. A., Zomer, A. L., Wells, J. M. & van Baarlen, P., 6 Jun 2019, In : Microbiology Resource Announcements. 8, 23, 3 p., e00227-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early-life feeding accelerates gut microbiota colonisation patterns in piglets

Choudhury, R., Middelkoop, A., Gerrits, W. J. J., Kemp, B., Bolhuis, J. E. & Kleerebezem, M., 18 Mar 2019, Trade-offs in science – keeping the balance: Abstracts of the WIAS Science Day 2019. Wageningen University & Research, p. 15-15

Research output: Chapter in Book/Report/Conference proceedingAbstract

Evaluating single-particle tracking by photo-activation localization microscopy (sptPALM) in Lactococcus lactis

van Beljouw, S. P. B., van der Els, S., Martens, K. J. A., Kleerebezem, M., Bron, P. A. & Hohlbein, J., 8 Mar 2019, In : Physical Biology. 16, 3, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells

Castro-Bravo, N., Margolles, A., Wells, J. M. & Ruas-Madiedo, P., 1 Apr 2019, In : Anaerobe. 56, p. 98-101 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
Open Access

Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression

Matualatupauw, J. C., O'Grada, C., Hughes, M. F., Roche, H. M., Afman, L. A. & Bouwman, J., 1 Oct 2019, In : Molecular Nutrition and Food Research. 63, 20, 1900101.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vivo transcriptomes of Streptococcus suis reveal genes required for niche-specific adaptation and pathogenesis

Arenas, J., Bossers-de Vries, R., Harders-Westerveen, J., Buys, H., Ruuls-van Stalle, L. M. F., Stockhofe-Zurwieden, N., Zaccaria, E., Tommassen, J., Wells, J. M., Smith, H. E. & de Greeff, A., 7 Apr 2019, In : Virulence. 10, 1, p. 334-351

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe

Ryan, P. M., Stolte, E. H., London, L. E. E., Wells, J. M., Long, S. L., Joyce, S. A., Gahan, C. G. M., Fitzgerald, G. F., Ross, R. P., Caplice, N. M. & Stanton, C., 8 Feb 2019, In : BMC Microbiology. 19, 1, 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)
Open Access

Microbial communities in a dynamic in vitro model for the human ileum resemble the human ileal microbiota

Stolaki, M., Minekus, M., Venema, K., Lahti, L., Smid, E. J., Kleerebezem, M. & Zoetendal, E. G., 1 Aug 2019, In : FEMS microbiology ecology. 95, 8, fiz096.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

PathwayLevelDataIntegration

Benis, N., Sep 2019

Research output: Non-textual formSoftwareOther research output

Open Access

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation

Koper, J. E. B., Loonen, L. M. P., Wells, J. M., Troise, A. D., Capuano, E. & Fogliano, V., 1 Feb 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800722.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)
Open Access

Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

Bron, P. A., Marcelli, B., Mulder, J., van der Els, S., Morawska, L. P., Kuipers, O. P., Kok, J. & Kleerebezem, M., 1 Apr 2019, In : Current Opinion in Biotechnology. 56, p. 61-68 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
Open Access
6 Citations (Scopus)

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice

Rogier, R., Ederveen, T. H. A., Wopereis, H., Hartog, A., Boekhorst, J., Van Hijum, S. A. F. T., Knol, J., Garssen, J., Walgreen, B., Helsen, M. M., Van Der Kraan, P. M., Van Lent, P. L. E. M., Van De Loo, F. A. J., Abdollahi-Roodsaz, S. & Koenders, M. I., 8 Jul 2019, In : PLoS ONE. 14, 7, e0219366.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The role of protein fermentation metabolites in post-weaning diarrhoea in piglets

Gilbert, M. S., van der Hee, B. & Gerrits, W. J. J., 2019, Energy and protein metabolism and nutrition. Chizzotti, M. L. (ed.). Wageningen Academic Publishers, Vol. 138. p. 361-362 (EAAP Publication; no. 138).

Research output: Chapter in Book/Report/Conference proceedingAbstract

Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics

Kleerebezem, M., Binda, S., Bron, P. A., Gross, G., Hill, C., van Hylckama Vlieg, J. E. T., Lebeer, S., Satokari, R. & Ouwehand, A. C., 1 Apr 2019, In : Current Opinion in Biotechnology. 56, p. 55-60

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Visualisation of dCas9 target search in vivo using an open-microscopy framework

Martens, K. J. A., van Beljouw, S. P. B., van der Els, S., Vink, J. N. A., Baas, S., Vogelaar, G. A., Brouns, S. J. J., van Baarlen, P., Kleerebezem, M. & Hohlbein, J., 7 Aug 2019, In : Nature Communications. 10, 1, 3552.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)
2018

A computational approach to study the transcriptional response of enterocytes exposed to luminal factors

Venkatasubramanian, P. B., 2018, Wageningen: Wageningen University. 214 p.

Research output: Thesisinternal PhD, WU

An acidic model pro-peptide affects the secondary structure, membrane interactions and antimicrobial activity of a crotalicidin fragment

Júnior, N. G. O., Cardoso, M. H., Cândido, E. S., van den Broek, D., de Lange, N., Velikova, N., Kleijn, J. M., Wells, J. M., Rezende, T. M. B., Franco, O. L. & de Vries, R., 24 Jul 2018, In : Scientific Reports. 8, 1, 11127.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Dietary diversity affects feeding behaviour of suckling piglets

Middelkoop, A., Choudhury, R., Gerrits, W. J. J., Kemp, B., Kleerebezem, M. & Bolhuis, J. E., Aug 2018, In : Applied Animal Behaviour Science. 205, p. 151-158

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Interactions of surface exopolysaccharides from bifidobacteriumand lactobacilluswithin the intestinal environment

Castro-Bravo, N., Wells, J. M., Margolles, A. & Ruas-Madiedo, P., 11 Oct 2018, In : Frontiers in Microbiology. 9, OCT, 2426.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Intestinal stem-cell organoids as experimental models to investigate feed efficiency

Ellen, E. D., Taverne, N., Taverne-Thiele, J. J., Madsen, O., Woelders, H., Bergsma, R., Knol, E. F., Kar, S. K., de Haas, Y., Groenen, M. & Wells, J. M., 28 Aug 2018, Book of Abstracts of the 69th Annual Meeting of the European Federation of Animal Science. Wageningen Academic Publishers, p. 478-478 (Book of Abstracts; vol. 24).

Research output: Chapter in Book/Report/Conference proceedingAbstract

KREAP: An automated Galaxy platform to quantify in vitro re-epithelialization kinetics

Fernandez-Gutierrez, M. M., van Zessen, D. B. H., van Baarlen, P., Kleerebezem, M. & Stubbs, A. P., 1 Jul 2018, In : GigaScience. 7, 7, giy078.

Research output: Contribution to journalLetterAcademicpeer-review

Open Access
1 Citation (Scopus)

Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

Bron, P. A. & Kleerebezem, M., 3 Aug 2018, In : Frontiers in Microbiology. 9, AUG, 1821.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Metatranscriptome analysis of the microbial fermentation of dietary milk proteins in the murine gut

Hugenholtz, F., Davids, M., Schwarz, J., Müller, M., Tomé, D., Schaap, P., Hooiveld, G. J. E. J., Smidt, H. & Kleerebezem, M., 1 Apr 2018, In : PLoS ONE. 13, 4, e0194066.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Microbial metabolic gatekeeping in the jejunum

Kleerebezem, M., 1 Jun 2018, In : Nature Microbiology. 3, 6, p. 650-651

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Mouse models for human intestinal microbiota research: a critical evaluation

Hugenholtz, F. & de Vos, W. M., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 1, p. 149-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
67 Citations (Scopus)
Open Access
20 Citations (Scopus)