Research Output 1988 2020

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2020

Chemokine CXCb1 stimulates formation of NETs in trunk kidney neutrophils of common carp

Pijanowski, L., Verburg van Kemenade, L. & Chadzinska, M., 1 Feb 2020, In : Developmental and Comparative Immunology. 103, 103521.

Research output: Contribution to journalArticleAcademicpeer-review

Carps
Chemokines
Neutrophils
Kidney
CXC Chemokines
2019
7 Citations (Scopus)

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M., Van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., De Vos, P., Dekker, J. & Wells, J. M., 5 Feb 2019, In : Scientific Reports. 9, 1, 1437.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Mucus
Immunity
Paneth Cells
T-Lymphocytes
3 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mucus
B-Lymphocytes
B-Lymphoid Precursor Cells
Transcriptome
Anti-Inflammatory Agents

A role for CXC chemokines and their receptors in stress axis regulation of common carp

Pijanowski, L., Verburg-van Kemenade, L. & Chadzinska, M., 1 Sep 2019, In : General and Comparative Endocrinology. 280, p. 194-199

Research output: Contribution to journalArticleAcademicpeer-review

CXCR Receptors
Carps
Chemokine Receptors
chemokines
Cyprinus carpio

Comparative and functional analysis of the digital mucus glands and secretions of tree frogs

Langowski, J. K. A., Singla, S., Nyarko, A., Schipper, H., van den Berg, F. T., Kaur, S., Astley, H. C., Gussekloo, S. W. S., Dhinojwala, A. & Van Leeuwen, J. L., 13 Jun 2019, In : Frontiers in Zoology. 16, 19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
mucus
Hylidae
secretion
frog
chemistry
1 Citation (Scopus)
Open Access
lactoglobulins
immunoglobulin E
Lactoglobulins
Lactose
glycation

Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance

Tadmor-Levi, R., Doron-faigenboim, A., Marcos-hadad, E., Petit, J., Hulata, G., Forlenza, M., Wiegertjes, G. F. & David, L., 26 Dec 2019, In : BMC Genomics. 20, 1, 1019.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Disease Resistance
Carps
Virus Diseases
Fishes
Viruses

Effects of stress and cortisol on the polarization of carp macrophages

Maciuszek, M., Rydz, L., Świtakowska, I., Verburg-van Kemenade, L. & Chadzińska, M., Nov 2019, In : Fish and Shellfish Immunology. 94, p. 27-37 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
carp
cortisol
Hydrocortisone
macrophages

Evidence of trained immunity in a fish: Conserved features in carp macrophages

Petit, J., Embregts, C. W. E., Forlenza, M. & Wiegertjes, G. F., 1 Jul 2019, In : Journal of Immunology. 203, 1, p. 216-224 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carps
Immunity
Fishes
Macrophages
Head Kidney

Genomic regions associated with IgE levels against culicoides spp. Antigens in three horse breeds

François, L., Hoskens, H., Velie, B. D., Stinckens, A., Tinel, S., Lamberigts, C., Peeters, L., Savelkoul, H. F. J., Tijhaar, E., Lindgren, G., Janssens, S., Ducro, B. J., Buys, N. & Schurink, A., 1 Aug 2019, In : Genes. 10, 8, 597.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Ceratopogonidae
Insect Bites and Stings
Immunoglobulin E
Horses
Hypersensitivity
4 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Allergens
Immunoglobulin E
Anacardiaceae
4 Citations (Scopus)

Intra-muscular and oral vaccination using a Koi Herpesvirus ORF25 DNA vaccine does not confer protection in common carp (Cyprinus carpio L.)

Embregts, C. W. E., Tadmor-Levi, R., Veselý, T., Pokorová, D., David, L., Wiegertjes, G. F. & Forlenza, M., Feb 2019, In : Fish and Shellfish Immunology. 85, p. 90-98

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cyprinid herpesvirus 3
oral vaccination
DNA Vaccines
vaccination
vaccine

Leveraging the medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever

Nyagwange, J., Awino, E., Tijhaar, E., Svitek, N., Pelle, R. & Nene, V., 1 Apr 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 9, p. 80-86

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Theileria parva
Theileriasis
Malaria
Theileria annulata
Cattle Diseases
1 Citation (Scopus)

Oxidative stress and immune aberrancies in attention-deficit/hyperactivity disorder (ADHD): a case–control comparison

Verlaet, A. A. J., Breynaert, A., Ceulemans, B., De Bruyne, T., Fransen, E., Pieters, L., Savelkoul, H. F. J. & Hermans, N., 1 May 2019, In : European Child and Adolescent Psychiatry. 28, 5, p. 719-729 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Oxidative Stress
Malondialdehyde
Immunoglobulin E
coenzyme Q10

Paralogs of Common Carp Granulocyte Colony-Stimulating Factor (G-CSF) Have Different Functions Regarding Development, Trafficking and Activation of Neutrophils

Katakura, F., Nishiya, K., Wentzel, A. S., Hino, E., Miyamae, J., Okano, M., Wiegertjes, G. F. & Moritomo, T., 19 Feb 2019, In : Frontiers in Immunology. 10, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neutrophil Activation
Carps
Granulocyte Colony-Stimulating Factor
Neutrophils
Kidney
4 Citations (Scopus)

Pichia pastoris yeast as a vehicle for oral vaccination of larval and adult teleosts

Embregts, C. W. E., Reyes-Lopez, F., Pall, A. C., Stratmann, A., Tort, L., Lorenzen, N., Engell-Sorensen, K., Wiegertjes, G. F., Forlenza, M., Sunyer, J. O. & Parra, D., Feb 2019, In : Fish and Shellfish Immunology. 85, p. 52-60

Research output: Contribution to journalArticleAcademicpeer-review

oral vaccination
Pichia pastoris
vaccination
Green Fluorescent Proteins
teleost

Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women

van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E. & Joost van Neerven, R. J., 12 Dec 2019, In : PLoS ONE. 14, 12, e0225825.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Toll-Like Receptors
Myeloid Cells
dendritic cells
young adults
Dendritic Cells
Open Access
Volatile Fatty Acids
Microbiota
Oligosaccharides
Human Milk
Prebiotics
1 Citation (Scopus)

Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway

Petit, J., Bailey, E. C., Wheeler, R. T., de Oliveira, C. A. F., Forlenza, M. & Wiegertjes, G. F., Feb 2019, In : Frontiers in Immunology. 10, 1 p., 280.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
C-Type Lectins
Glucans
Carps
Macrophages
Genes
8 Citations (Scopus)

Systematic Comparison of Zwitterionic and Non-Zwitterionic Antifouling Polymer Brushes on a Bead-Based Platform

van Andel, E., Lange, S. C., Pujari, S. P., Tijhaar, E. J., Smulders, M. M. J., Savelkoul, H. F. J. & Zuilhof, H., Feb 2019, In : Langmuir. 35, 5, p. 1181–1191

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
antifouling
brushes
Brushes
beads
Polymers
2 Citations (Scopus)

The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE-mediated cow's milk allergy

Ruinemans-Koerts, J., Schmidt-Hieltjes, Y., Jansen, A., Savelkoul, H. F. J., Plaisier, A. & van Setten, P., Mar 2019, In : Clinical and Experimental Allergy. 49, 3, p. 350-356

Research output: Contribution to journalArticleAcademicpeer-review

Milk Hypersensitivity
Basophils
Immunoglobulin E
Food
Placebos
3 Citations (Scopus)

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion

van Golen, R. F., Reiniers, M. J., Marsman, G., Alles, L. K., van Rooyen, D. M., Petri, B., Van der Mark, V. A., van Beek, A. A., Meijer, B., Maas, M. A., Zeerleder, S., Verheij, J., Farrell, G. C., Luken, B. M., Teoh, N. C., van Gulik, T. M., Murphy, M. P. & Heger, M., 1 Jun 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 6, p. 1192-1200

Research output: Contribution to journalArticleAcademicpeer-review

Reperfusion
Ischemia
Liver
Oxidative Stress
Nucleosomes
1 Citation (Scopus)

The impact of pectin supplementation on intestinal barrier function in healthy young adults and healthy elderly

Wilms, E., Jonkers, D. M. A. E., Savelkoul, H. F. J., Elizalde, M., Tischmann, L., de Vos, P., Masclee, A. A. M. & Troost, F. J., 1 Jul 2019, In : Nutrients. 11, 7, 1554.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
young adults
pectins
Young Adult
placebos
Placebos
2 Citations (Scopus)

The kinetics of cellular and humoral immune responses of common carp to presporogonic development of the myxozoan Sphaerospora molnari

Korytář, T., Wiegertjes, G. F., Zusková, E., Tomanová, A., Lisnerová, M., Patra, S., Sieranski, V., Šíma, R., Born-Torrijos, A., Wentzel, A. S., Blasco-Monleon, S., Yanes-Roca, C., Policar, T. & Holzer, A. S., 6 May 2019, In : Parasites & Vectors. 12, 1, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carps
Humoral Immunity
Cellular Immunity
Parasites
Fishes
1 Citation (Scopus)

Toll-like receptor agonists as adjuvants for inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine

Vreman, S., McCaffrey, J., Popma-de Graaf, D. J., Nauwynck, H., Savelkoul, H. F. J., Moore, A., Rebel, J. M. J. & Stockhofe-Zurwieden, N., 1 Jun 2019, In : Veterinary Immunology and Immunopathology. 212, p. 27-37 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Porcine respiratory and reproductive syndrome virus
Porcine reproductive and respiratory syndrome virus
Toll-Like Receptors
agonists
adjuvants

Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol®

Verlaet, A., van der Bolt, N., Meijer, B., Breynaert, A., Naessens, T., Konstanti, P., Smidt, H., Hermans, N., Savelkoul, H. F. J. & Teodorowicz, M., 22 Jan 2019, In : Nutrients. 11, 2

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Toll-Like Receptors
agonists
interleukin-10
microorganisms
metabolism
9 Citations (Scopus)

Vaccination of carp against SVCV with an oral DNA vaccine or an insect cells-based subunit vaccine

Embregts, C. W. E., Rigaudeau, D., Tacchi, L., Pijlman, G. P., Kampers, L., Veselý, T., Pokorová, D., Boudinot, P., Wiegertjes, G. F. & Forlenza, M., Feb 2019, In : Fish and Shellfish Immunology. 85, p. 66-77

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Subunit Vaccines
DNA Vaccines
vaccination
subunit vaccines
vaccine

Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms

Dóró, É., Jacobs, S. H., Hammond, F. R., Schipper, H., Pieters, R. P. M., Carrington, M., Wiegertjes, G. F. & Forlenza, M., 24 Sep 2019, In : eLife. 8, e48388.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Trypanosomiasis
Vertebrates
Zebrafish
Barreling
Trypanosoma

Water flow in soils with heterogeneous macropore geometries

Faúndez Urbina, C. A., van Dam, J. C., Hendriks, R. F. A., van den Berg, F., Gooren, H. P. A. & Ritsema, C. J., 22 Aug 2019, In : Vadose Zone Journal. 18, 1, 190015.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
macropores
macropore
water flow
outflow
geometry
2018

Adherence to home fortification with micronutrient powders in Kenyan pre-school children: Self-reporting and sachet counts compared to an electronic monitoring device

Teshome, E. M., Oriaro, V. S., Andango, P. E. A., Prentice, A. M. & Verhoef, J. C. M., 1 Feb 2018, In : BMC Public Health. 18, 205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Micronutrients
Powders
Equipment and Supplies
Hemoglobins
Iron

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

Van Beek, A. A., Fransen, F., Meijer, B., de Vos, P., Knol, E. F. & Savelkoul, H. F. J., 29 Nov 2018, In : Immunity and Ageing. 15, 1, 32.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Basophils
Microbiota
Bone Marrow
Phenotype
Spleen

Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro

Nyagwange, J., Nene, V., Mwalimu, S., Henson, S., Steinaa, L., Nzau, B., Tijhaar, E. & Pelle, R., 1 May 2018, In : Veterinary Immunology and Immunopathology. 199, p. 8-14

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Theileria parva
Sporozoites
sporozoites
Computer Simulation
Theileriasis
9 Citations (Scopus)

Antimicrobial peptides within the Yellowtail Kingfish (Seriola lalandi)

Muncaster, S., Kraakman, K., Gibbons, O., Mensink, K., Forlenza, M., Jacobson, G. & Bird, S., Mar 2018, In : Developmental and Comparative Immunology. 80, p. 67-80

Research output: Contribution to journalArticleAcademicpeer-review

Hepcidins
Fishes
Peptides
Genes
Complementary DNA
3 Citations (Scopus)

BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells

den Hartog, C. G., van Osch, T. L. J., Vos, M., Meijer, B., Savelkoul, H. F. J., van Neerven, R. J. J. & Brugman, S., 9 Feb 2018, In : European journal of immunology. 48, 2, p. 283-292

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Interleukin-10
Immunoglobulin A
Blood Cells
B-Lymphocytes
Virus Diseases
2 Citations (Scopus)

Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: Results from a nutritional intervention study with bovine lactoferrin, GOS and Vitamin D

van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E. & van Neerven, R. J. J., 20 Nov 2018, In : Frontiers in Immunology. 9, 2677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactoferrin
Vitamin D
Dendritic Cells
Toll-Like Receptors
Placebos
3 Citations (Scopus)

Bovine lactoferrin modulates dendritic cell differentiation and function

Perdijk, O., van Neerven, R. J. J., van den Brink, E., Savelkoul, H. F. J. & Brugman, S., 29 Jun 2018, In : Nutrients. 10, 7, 848.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactoferrin
lactoferrin
dendritic cells
cell differentiation
Dendritic Cells
4 Citations (Scopus)

Characterization of the Theileria parva sporozoite proteome

Nyagwange, J., Tijhaar, E., Ternette, N., Mobegi, F., Tretina, K., Silva, J. C., Pelle, R. & Nene, V., Mar 2018, In : International Journal for Parasitology. 48, 3-4, p. 265-273

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Theileria parva
Sporozoites
Proteome
Theileriasis
Proteins

Comparative review on microbiota manipulation: lessons from fish, plants, livestock and human research

Brugman, S., Ikeda-Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J. & Bakker, P. A. H. M., 5 Sep 2018, In : Frontiers in Nutrition. 5, 15 p., 80.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Dysbiosis
Livestock
Fishes
livestock
9 Citations (Scopus)

Cow's milk and immune function in the respiratory tract: Potential mechanisms

Perdijk, O., van Splunter, M., Savelkoul, H. F. J., Brugman, S. & van Neerven, J., 12 Feb 2018, In : Frontiers in Immunology. 9, FEB, 143.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Respiratory System
Milk
Respiratory Tract Infections
Asthma
Allergens

Effects of bovine immunoglobulin on immune function, allergy and infection

Ulfman, L. H., Leusen, J. H. W., Savelkoul, H. F. J., Warner, J. O. & van Neerven, R. J. J., 22 Jun 2018, In : Frontiers in Nutrition. 5, 20 p., 52.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Immunoglobulins
Hypersensitivity
Immunoglobulin G
Infection
Colostrum
Open Access
Saponins
Immersion
Zebrafish
Larva
Anti-Bacterial Agents

How can we define "optimal microbiota?": a comparative review of structure and functions of microbiota of animals, fish and plants in agriculture

Ikeda-Ohtsubo, W., Brugman, S., Warden, C. H., Rebel, A., Folkerts, G. & Pieterse, C. M. J., 28 Nov 2018, In : Frontiers in Nutrition. 5, 113, 18 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Agriculture
Fishes
agriculture
fish
21 Citations (Scopus)

Immunological effects of human milk oligosaccharides

Triantis, V., Bode, L. & van Neerven, J. R. J., 2 Jul 2018, In : Frontiers in Pediatrics. 6, 190.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
Oligosaccharides
Microbiota
Immune System Diseases
Cell Surface Receptors
1 Citation (Scopus)
Open Access
Maillard Reaction
Advanced Glycosylation End Products
Immunomodulation
Livestock
Pets
7 Citations (Scopus)

Induction of human tolerogenic dendritic cells by 3′-sialyllactose via TLR4 is explained by LPS contamination

Perdijk, O., Joost Van Neerven, R. J., Meijer, B., Savelkoul, H. F. J. & Brugman, S., 1 Mar 2018, In : Glycobiology. 28, 3, p. 126-130

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dendritic Cells
Contamination
3'-sialyllactose
Toll-Like Receptor 4
Toll-Like Receptors
1 Citation (Scopus)

Induction of trained innate immunity in human monocytes by bovine milk and milk-derived immunoglobulin G

van Splunter, M., van Osch, T. L. J., Brugman, S., Savelkoul, H. F. J., Joosten, L. A. B., Netea, M. G. & van Neerven, R. J. J., 27 Sep 2018, In : Nutrients. 10, 10, 1378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
immunoglobulin G
Innate Immunity
monocytes
Monocytes
Milk
4 Citations (Scopus)

Neonatal porcine blood derived dendritic cell subsets show activation after TLR2 or TLR9 stimulation

Vreman, S., Auray, G., Savelkoul, H. F. J., Rebel, A., Summerfield, A. & Stockhofe-Zurwieden, N., Jul 2018, In : Developmental and Comparative Immunology. 84, p. 361-370

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dendritic Cells
Swine
Ligands
Toll-Like Receptor 2
Antigen-Presenting Cells

Onderzoek naar het ontstaan van darmontstekingen: het zebravismodel

Brugman, S., Forlenza, M. & Wiegertjes, G., 2018, In : Biotechniek. 57, 1, p. 9-14

Research output: Contribution to journalArticleProfessional

Open Access
3 Citations (Scopus)

Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

van Splunter, M., van Hoffen, E., Floris-Vollenbroek, E. G., Timmerman, H., van de Bos, E. L., Meijer, B., Ulfman, L. H., Witteman, B., Wells, J. M., Brugman, S., Savelkoul, H. F. J. & van Neerven, R. J. J., 2018, In : Mucosal Immunology. 11, 4, p. 1254-1264

Research output: Contribution to journalArticleAcademicpeer-review

Cholera
Large Intestine
Respiratory System
Immunoglobulin A
Vaccination
1 Citation (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Nuts
Anas