Transcription profiling of rat colonic mucosa at different time points following Salmonella infection

  • G.C.H. Rodenburg (Creator)
  • Evelien Kramer (Creator)
  • I. Bovee-Oudenhoven (Creator)
  • Jaap Keijer (Creator)

Dataset

Description

Salmonella enteritidis is suggested to translocate in the small intestine. Previously we identified that prebiotics, fermented in the colon, increased Salmonella translocation in rats, suggesting involvement of the colon in translocation. Effects of Salmonella on colonic gene expression in vivo are largely unknown. The aim of this study was to characterize time dependent Salmonella induced changes of colonic mucosal gene expression in rats using whole genome microarrays. Rats were orally infected with Salmonella enteritidis to mimic a foodbore infection and colonic gene expression was determined at day 1, 3 and 6 post-infection (n=8 per timepoint). Agilent rat whole genome microarray (G4131A Agilent Technologies) were used. Results indicate that colon is clearly a target tissue for Salmonella considering the abundant changes in mucosal gene expression observed.
Date made available18 Oct 2007
PublisherRikilt - Institute of Food Safety

Research Output

Salmonella induces prominent gene expression in rat colon, which is affected by dietary fructo-oligosaccharides

Rodenburg, G. C. H., Keijer, J., Kramer, E. H. M., Roosing, S., Vink, C., Katan, M. B., van der Meer, R. & Bovee-Oudenhoven, I. M. J., 2007, In : BMC Microbiology. 7, 36 p., 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 27 Citations (Scopus)

    Cite this

    Rodenburg, G. C. H. (Creator), Kramer, E. (Creator), Bovee-Oudenhoven, I. (Creator), Keijer, J. (Creator) (18 Oct 2007). Transcription profiling of rat colonic mucosa at different time points following Salmonella infection. Rikilt - Institute of Food Safety.