TNFalpha and IL-6 induced anorexia: effects on serotonin turnover



Anorexia can occur as a serious complication of chronic disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. We studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after an intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.
Date made available31 May 2016
PublisherWageningen University

Research Output

Increased hypothalamic serotonin turnover in inflammation-induced anorexia

Dwarkasing, J. T., Witkamp, R. F., Boekschoten, M. V., ter Laak, M. C., Heins, M. S. & van Norren, K., 2016, In : BMC Neuroscience. 17, 1, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 15 Citations (Scopus)

    Cite this

    Dwarkasing, J. (Creator), Witkamp, R. (Creator), Boekschoten, M. (Creator), ter Laak, M. C. (Creator), Flik, G. (Creator), van Norren, K. (Creator) (31 May 2016). TNFalpha and IL-6 induced anorexia: effects on serotonin turnover. Wageningen University.