The host response of IBS patients to allogenic and autologous faecal microbiota transfer

  • Savanne Holster (Creator)
  • Guido Hooiveld (Creator)
  • Robert-Jan Brummer (Creator)
  • Julia König (Creator)

Dataset

Description

In this randomised placebo-controlled trial, irritable bowel syndrome (IBS) patients were treated with faecal material from a healthy donor (n=8, allogenic FMT) or with their own faecal microbiota (n=8, autologous FMT). The faecal transplant was administered by whole colonoscopy into the caecum (30 g of stool in 150 ml sterile saline). Two weeks before the FMT (baseline) as well as two and eight weeks after the FMT, the participants underwent a sigmoidoscopy, and biopsies were collected at a standardised location (20-25 cm from the anal verge at the crossing with the arteria iliaca communis) from an uncleansed sigmoid. In patients treated with allogenic FMT, predominantly immune response-related genes sets were induced, with the strongest response two weeks after FMT. In patients treated with autologous FMT, predominantly metabolism-related gene sets were affected.
Date made available14 Oct 2019
PublisherWageningen University

Research Output

Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome

Holster, S., Hooiveld, G. J., Repsilber, D., de Vos, W. M., Brummer, R. J. & König, J., 8 Oct 2019, In : Biomolecules. 9, 10, 586.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • Cite this

    Holster, S. (Creator), Hooiveld, G. J. E. J. (Creator), Brummer, R. (Creator), König, J. (Creator) (14 Oct 2019). The host response of IBS patients to allogenic and autologous faecal microbiota transfer. Wageningen University.