Research Output per year
Molecular mechanisms triggered by high dietary beta-carotene (BC) intake in liver are largely unknown. We performed microarray gene expression analysis on liver tissue of BC supplemented beta-carotene 15,150-monooxygenase 1 knockout (Bcmo1-/-) mice, which are—like humans—able to accumulate BC. This was compared with litter mates being wild-type (Bcmo1+/+) mice, and we analysed both males and females, as we previously showed that in lung tissue we observed opposite gene regulation between males and females.
|Date made available||26 Sep 2017|
Gene expression response of mouse lung, liver and white adipose tissue to beta-carotene supplementation, knockout of Bcmo1 and sexHelden, Y. G. J., Godschalk, R. W. L., von Lintig, J. & Keijer, J., 2011, In : Molecular Nutrition & Food Research. 55, 10, p. 1466-1474
Research output: Contribution to journal › Article › Academic › peer-review
Nutritional effects by beta-carotene versus control in lung, inguinal white adipose tissue, and liver in males and females of control wildtype mice versus BCMO/BCO1 knockout mice
van Schothorst, E. (Creator), Wageningen University, 26 Sep 2017
van Schothorst, E. M. (Creator), Helden, Y. G. J. (Creator), Keijer, J. (Creator), Hessel, S. (Creator), Bunschoten, J. E. (Creator), von Lintig, J. (Creator), Lietz, G. (Creator) (26 Sep 2017). Nutritional effects by beta-carotene in liver in males and females of control wildtype mice versus BCMO knockout mice. Wageningen University.