Microarray of five Caenorhabiditis elegans genotypes with or without a human alpha-synuclein transgene in the genetic background

Dataset

Description

Previous studies in Caenorhabditis elegans expressing the human alpha-synuclein protein, have shown that protein aggregation and some aetiologies of Parkinsons disease can be recapitulated in this model nematode. However, it is known that the genetic background is important in how the disease progresses in humans. This study sought to address this topic in the model nematode C. elegans. In this study we measured gene expression in C. elegans nematodes with different genetic backgrounds (JU511, JU1926, JU1931, and JU1941) with an introgression of and N2 region with the alpha-synuclein protein in chromosome IV. We measured expression in the wild-type strains and strains with the transgene. Each strain was measured in three biological replica's at an age of 48 hours post synchronization by bleaching.
Date made available11 Feb 2019
PublisherWageningen University & Research

Research Output

Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

Wang, Y. A., Snoek, B. L., Sterken, M. G., Riksen, J. A. G., Stastna, J. J., Kammenga, J. E. & Harvey, S. C., 20 Mar 2019, In : BMC Genomics. 20, 1, 12 p., 232.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 2 Citations (Scopus)

    Cite this

    Sterken, M. G. (Creator) (11 Feb 2019). Microarray of five Caenorhabiditis elegans genotypes with or without a human alpha-synuclein transgene in the genetic background. Wageningen University & Research.