Microarray experiment comparing gene expression in the bar-1 mutant EW15 with wild-type strain N2 in Caenorhabditis elegans

Dataset

Description

The Wnt-pathway is a key-signalling pathway in metazoans. The beta-catenins, which include bar-1, have a function in gene expression regulation in Wnt-signalling. In this study, the effect of a loss-of-function mutation (bar-1(ga80) in the strain EW15) on gene-expression was tested. To this end age-synchronized populations of both N2 (wild-type) and EW15 were grown for 48 hours at 20 degrees Celsius, after which populations were collected and total RNA was isolated. For each genotype six replicates were collected in three batches of two replicates.
Date made available12 Jul 2019
PublisherWageningen University & Research

Research Output

Loss-of-function of b-catenin bar-1 slows development and activates the Wnt pathway in Caenorhabditis elegans

van der Bent, M. L., Sterken, M. G., Volkers, J. M., Riksen, J. A. G., Schmid, T., Hajnal, A., Kammenga, J. E. & Snoek, L. B., 2014, In : Scientific Reports. 4, 7 p., 4926.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 10 Citations (Scopus)

    Cite this

    Sterken, M. G. (Creator) (12 Jul 2019). Microarray experiment comparing gene expression in the bar-1 mutant EW15 with wild-type strain N2 in Caenorhabditis elegans. Wageningen University & Research.