MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

  • David Latrasse (Creator)
  • Teddy Jégu (Creator)
  • Huchen Li (Creator)
  • Axel de Zelicourt (Creator)
  • Cécile Raynaud (Creator)
  • Stéphanie Legras (Creator)
  • Andrea Gust (Creator)
  • Olga Samajova (Creator)
  • Alaguraj Veluchamy (Creator)
  • Naganand Rayapuram (Creator)
  • Juan Sebastian Ramirez-Prado (Creator)
  • Olga Kulikova (Creator)
  • Jean Colcombet (Creator)
  • Baptiste Genot (Creator)
  • Ton Bisseling (Creator)
  • Moussa Benhamed (Creator)
  • Heribert Hirt (Creator)

Dataset

Description

Microbial-associated molecular patterns (MAMPs) activate several MAP Kinases (MAPKs), which are major regulators of the innate immune response in Arabidopsis that induce large-scale changes in gene expression. Here, we determined whether MAMP-triggered gene expression involves chromatin modifications at the chromosomal level. Our results show that histone acetylation and deacetylation are major regulators of MAMP-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defense gene expression and innate immunity. The MAPK MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. By studying a number of gene loci that undergo MAMP-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.
Date made available13 Jun 2017

Research Output

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Latrasse, D., Jégu, T., Li, H., de Zelicourt, A., Raynaud, C., Legras, S., Gust, A., Samajova, O., Veluchamy, A., Rayapuram, N., Ramirez-Prado, J. S., Kulikova, O., Colcombet, J., Bigeard, J., Genot, B., Bisseling, T., Benhamed, M. & Hirt, H., 2017, In : Genome Biology. 18, 1, 131.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 24 Citations (Scopus)

    Cite this

    Latrasse, D. (Creator), Jégu, T. (Creator), Li, H. (Creator), de Zelicourt, A. (Creator), Raynaud, C. (Creator), Legras, S. (Creator), Gust, A. (Creator), Samajova, O. (Creator), Veluchamy, A. (Creator), Rayapuram, N. (Creator), Ramirez-Prado, J. S. (Creator), Kulikova, O. (Creator), Colcombet, J. (Creator), Genot, B. (Creator), Bisseling, A. H. J. (Creator), Benhamed, M. (Creator), Hirt, H. (Creator) (13 Jun 2017). MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity