Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

  • Haksier Ehedego (Creator)
  • Mark Boekschoten (Creator)
  • Wei Hu (Creator)
  • Carina Doler (Creator)
  • Johannes Haybaeck (Creator)
  • Nikolaus Gassler (Creator)
  • Michael Muller (Creator)
  • Christian Liedtke (Creator)
  • Christian Trautwein (Creator)



Overexpression of p21 in NEMOΔhepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage.
Date made available1 Mar 2015
PublisherWageningen University

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