Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

Haksier Ehedego (Creator)
Mark Boekschoten (Creator)
Wei Hu (Creator)
Carina Doler (Creator)
Johannes Haybaeck (Creator)
Nikolaus Gassler (Creator)
Michael Muller (Creator)
Christian Liedtke (Creator)
Christian Trautwein (Creator)

Dataset

Description

Overexpression of p21 in NEMOΔhepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage.

Date made available	1 Mar 2015
Publisher	Wageningen University

Keywords

Mus musculus

Accession numbers

GSE61100
PRJNA260220

Access Dataset

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61100

1 Article

p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis
Ehedego, H., Boekschoten, M. V., Hu, W., Doler, C., Haybaeck, J., Gassler, N., Muller, M. R., Liedtke, C. & Trautwein, C., 2015, In: Cancer Research. 75, 6, p. 1144-1155 12 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
20 Citations (Scopus)

Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

Description

Keywords

Accession numbers

Access Dataset

Research output

p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis

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