Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver

  • Haksier Ehedego (Creator)
  • Mark Boekschoten (Creator)
  • Wei Hu (Creator)
  • Carina Doler (Creator)
  • Johannes Haybaeck (Creator)
  • Nikolaus Gassler (Creator)
  • Michael Muller (Creator)
  • Christian Liedtke (Creator)
  • Christian Trautwein (Creator)

Dataset

Description

Overexpression of p21 in NEMOΔhepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage.
Date made available1 Mar 2015
PublisherWageningen University

Research Output

p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis

Ehedego, H., Boekschoten, M. V., Hu, W., Doler, C., Haybaeck, J., Gassler, N., Muller, M. R., Liedtke, C. & Trautwein, C., 2015, In : Cancer Research. 75, 6, p. 1144-1155 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 13 Citations (Scopus)

    Cite this

    Ehedego, H. (Creator), Boekschoten, M. (Creator), Hu, W. (Creator), Doler, C. (Creator), Haybaeck, J. (Creator), Gaßler, N. (Creator), Muller, M. (Creator), Liedtke, C. (Creator), Trautwein, C. (Creator) (1 Mar 2015). Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver. Wageningen University.