Identification of the core gene-regulatory network that governs the dynamic adaptation of intestinal homeostasis during conventionalization in mice

Dataset

Description

Molecular adaptation of the intestinal mucosa occurs during microbial conventionalization to maintain a balanced immune response. However, the genetic regulation of such adaptation is obscure. Here, combined analysis of germ free and conventionalized mice revealed that the major molecular adaptations were initiated at day 4 of conventionalization with a strong induction of innate immune functions followed by stimulation of adaptive immune functions. We identified central regulatory genes and reconstructed a common regulatory network that appeared to be sufficient to regulate the dynamic adaptation of the intestinal mucosa to the colonizing microbiota. The majority of the genes within this regulatory network play roles in mucosal inflammatory diseases in mouse and human. We propose that the identified central regulatory network may serve as a genetic signature for control of intestinal homeostasis in healthy mice and may help to unravel the genetic basis of pathway dysregulation in human intestinal inflammatory diseases.
Date made available11 Jul 2012
PublisherWageningen University

Research Output

Gut bacteria-host metabolic interplay during conventionalisation of the mouse germfree colon

El Aidy, S., Derrien, M. M. N., Merrifield, C. A., Levenez, F., Dore, J., Boekschoten, M. V., Dekker, J., Holmes, E., Zoetendal, E. G., van Baarlen, P., Claus, S. P. & Kleerebezem, M., 2013, In : ISME Journal. 7, p. 743-755

Research output: Contribution to journalArticleAcademicpeer-review

  • 57 Citations (Scopus)

    The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation

    El Aidy, S., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Holmes, E., Claus, S. P., Reijngoud, D. J. & Kleerebezem, M., 2013, In : Gut. 62, p. 1306-1314

    Research output: Contribution to journalArticleAcademicpeer-review

  • 69 Citations (Scopus)

    Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice

    El Aidy, S., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J., Levenez, F., Dore, J., Dekker, J., Samsom, J. N., Nieuwenhuis, E. E. S. & Kleerebezem, M., 2012, In : Mucosal Immunology. 5, p. 567-579

    Research output: Contribution to journalArticleAcademicpeer-review

  • 120 Citations (Scopus)

    Cite this

    El Aidy, S. (Creator), van Baarlen, P. (Creator), Hooiveld, G. (Creator), Kleerebezem, M. (Creator) (11 Jul 2012). Identification of the core gene-regulatory network that governs the dynamic adaptation of intestinal homeostasis during conventionalization in mice. Wageningen University.