Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [mouse]

Dataset

Description

Background: The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA; also known as INT-747 or 6α-ethyl-chenodeoxycholic acid), a promising drug for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes, activates FXR. Mouse studies demonstrated that FXR activation by OCA (INT-747) alters hepatic expression of many genes. However, no data are available on the effects of OCA in human liver. Here, we generated gene expression profiles in human precision-cut liver slices (hPCLS) after treatment with OCA.
Date made available27 Jan 2016
PublisherWageningen University

Research Output

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

IJssennagger, N., Janssen, A. W. F., Milona, A., Ramos Pittol, J. M., Hollman, D. A. A., Mokry, M., Betzel, B., Berends, F. J., Janssen, I. M., van Mil, S. W. C. & Kersten, S., 2016, In : Journal of Hepatology. p. 1158-1166 64.

Research output: Contribution to journalArticleAcademicpeer-review

  • 36 Citations (Scopus)

    Cite this

    IJssennagger, N. (Creator), Janssen, A. (Creator), Kersten, S. (Creator), van Mil, S. W. C. (Creator) (27 Jan 2016). Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [mouse]. Wageningen University.