Research output per year
Research output per year
Description
Background: The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA; also known as INT-747 or 6α-ethyl-chenodeoxycholic acid), a promising drug for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes, activates FXR. Mouse studies demonstrated that FXR activation by OCA (INT-747) alters hepatic expression of many genes. However, no data are available on the effects of OCA in human liver. Here, we generated gene expression profiles in human precision-cut liver slices (hPCLS) after treatment with OCA.
| Date made available | 27 Jan 2016 |
|---|---|
| Publisher | Wageningen University |
Keywords
- Mus musculus
Accession numbers
- GSE76162
- PRJNA306504
Research output
- 1 Article
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Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid
IJssennagger, N., Janssen, A. W. F., Milona, A., Ramos Pittol, J. M., Hollman, D. A. A., Mokry, M., Betzel, B., Berends, F. J., Janssen, I. M., van Mil, S. W. C. & Kersten, S., 2016, In: Journal of Hepatology. p. 1158-1166 64.Research output: Contribution to journal › Article › Academic › peer-review
72 Citations (Scopus)
Datasets
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Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid
IJssenagger, N. (Creator), Janssen, A. W. F. (Creator), Kersten, A. H. (Creator) & van Mil, S. W. C. (Creator), Wageningen University, 27 Jan 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76163
Dataset
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Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [human]
IJssennagger, N. (Creator), Janssen, A. (Creator), van Mil, S. (Creator) & Kersten, S. (Creator), Wageningen University, 27 Jan 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76161
Dataset