Gene expression changes in cecum mucosa upon dietary treatment

  • G.C.H. Rodenburg (Creator)
  • Evelien Kramer (Creator)
  • Ingeborg Bovee-Oudenhoven (Creator)
  • Jaap Keijer (Creator)

Dataset

Description

To increase our knowledge of the effects of Fructo oligosaccharides (FOS) on the intestinal barrier function in rats, a controlled rat infection study was performed. Two groups of rats (n=12 per group) were adapted to a diet with or without FOS. mRNA was collected from the mucosa of the cecum and changes in gene expression were assessed using an agilent rat whole genome microarray (G4131A Agilent Technologies). Results indicate that dietary FOS influences immune response and wound healing mechanisms, which will most likely affect the intestinal barrier.
Date made available31 Dec 2007
PublisherRikilt - Institute of Food Safety

Research Output

A framework to identify physiological responses in microarray based gene expression studies: selection and interpretation of biologically relevant genes

Rodenburg, G. C. H., Heidema, A. G., Boer, J. M. A., Bovee-Oudenhoven, I. M. J., Feskens, E. J. M., Mariman, E. C. M. & Keijer, J., 2008, In : Physiological genomics. 33, p. 78-90

Research output: Contribution to journalArticleAcademicpeer-review

  • 35 Citations (Scopus)

    Cite this

    Rodenburg, G. C. H. (Creator), Kramer, E. (Creator), Bovee-Oudenhoven, I. (Creator), Keijer, J. (Creator) (31 Dec 2007). Gene expression changes in cecum mucosa upon dietary treatment . Rikilt - Institute of Food Safety.