Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

  • Simon Kebede Merid (Creator)
  • Alexei Novoloaca (Creator)
  • Gemma C. Sharp (Creator)
  • Leanne Kupers (Creator)
  • Alvin T. Kho (Creator)
  • Ritu Roy (Creator)
  • Lu Gao (Creator)
  • Isabella Annesi-Maesano (Creator)
  • Pooja Jain (Creator)
  • Michelle Plusquin (Creator)
  • Manolis Kogevinas (Creator)
  • Catherine Allard (Creator)
  • Florianne O. Vehmeijer (Creator)
  • Nabila Kazmi (Creator)
  • Lucas A. Salas (Creator)
  • Faisal I. Rezwan (Creator)
  • Hongmei Zhang (Creator)
  • Sylvain Sebert (Creator)
  • Darina Czamara (Creator)
  • Sheryl L. Rifas-Shiman (Creator)
  • Phillip E. Melton (Creator)
  • Debbie A. Lawlor (Creator)
  • Göran Pershagen (Creator)
  • Carrie V. Breton (Creator)
  • Karen Huen (Creator)
  • Nour Baïz (Creator)
  • Luigi Gagliardi (Creator)
  • Tim S. Nawrot (Creator)
  • Eva Corpeleijn (Creator)
  • Patrice Perron (Creator)
  • Liesbeth Duijts (Creator)
  • Ellen Aagaard Nohr (Creator)
  • Mariona Bustamante (Creator)
  • Susan Ewart (Creator)
  • Wilfried Karmaus (Creator)
  • Shanshan Zhao (Creator)
  • Christian M. Page (Creator)
  • Zdenko Herceg (Creator)
  • Marjo Riitta Jarvelin (Creator)
  • Jari Lahti (Creator)
  • Andrea A. Baccarelli (Creator)
  • Denise Anderson (Creator)
  • Priyadarshini Kachroo (Creator)
  • Caroline L. Relton (Creator)
  • Anna Bergström (Creator)
  • Brenda Eskenazi (Creator)
  • Munawar Hussain Soomro (Creator)
  • Paolo Vineis (Creator)
  • Harold Snieder (Creator)
  • Luigi Bouchard (Creator)
  • Vincent W V Jaddoe (Creator)
  • Thorkild I.A. Sørensen (Creator)
  • Martine Vrijheid (Creator)
  • Syed Hasan Arshad (Creator)
  • John W. Holloway (Creator)
  • Siri E. Håberg (Creator)
  • Per Magnus (Creator)
  • Terence Dwyer (Creator)
  • Elisabeth B. Binder (Creator)
  • Dawn L. DeMeo (Creator)
  • Judith M. Vonk (Creator)
  • John Newnham (Creator)
  • Kelan G. Tantisira (Creator)
  • Inger Kull (Creator)
  • Joseph Wiemels (Creator)
  • Barbara Heude (Creator)
  • Jordi Sunyer (Creator)
  • Wenche Nystad (Creator)
  • Monica C. Munthe-Kaas (Creator)
  • Katri Raïkkönen (Creator)
  • Emily Oken (Creator)
  • Rae Chi Huang (Creator)
  • Scott T. Weiss (Creator)
  • Josep Maria Antó (Creator)
  • Jean Bousquet (Creator)
  • Ashish Kumar (Creator)
  • Cilla Söderhäll (Creator)
  • Catarina Almqvist (Creator)
  • Andres Cardenas (Creator)
  • Olena Gruzieva (Creator)
  • Cheng Jian Xu (Creator)
  • Sarah E. Reese (Creator)
  • Juha Kere (Creator)
  • Petter Brodin (Creator)
  • Olivia Solomon (Creator)
  • Matthias Wielscher (Creator)
  • Nina Holland (Creator)
  • Akram Ghantous (Creator)
  • Marie France Hivert (Creator)
  • Janine F Felix (Creator)
  • Gerard H. Koppelman (Creator)
  • Stephanie J. London (Creator)
  • Erik Melén (Creator)

Dataset

Description

Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P
Date made available2 Mar 2020
PublisherKarolinska Institute
  • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

    Merid, S. K., Novoloaca, A., Sharp, G. C., Küpers, L. K., Kho, A. T., Roy, R., Gao, L., Annesi-Maesano, I., Jain, P., Plusquin, M., Kogevinas, M., Allard, C., Vehmeijer, F. O., Kazmi, N., Salas, L. A., Rezwan, F. I., Zhang, H., Sebert, S., Czamara, D., Rifas-Shiman, S. L. & 73 others, Melton, P. E., Lawlor, D. A., Pershagen, G., Breton, C. V., Huen, K., Baiz, N., Gagliardi, L., Nawrot, T. S., Corpeleijn, E., Perron, P., Duijts, L., Nohr, E. A., Bustamante, M., Ewart, S. L., Karmaus, W., Zhao, S., Page, C. M., Herceg, Z., Jarvelin, M. R., Lahti, J., Baccarelli, A. A., Anderson, D., Kachroo, P., Relton, C. L., Bergström, A., Eskenazi, B., Soomro, M. H., Vineis, P., Snieder, H., Bouchard, L., Jaddoe, V. W., Sørensen, T. I. A., Vrijheid, M., Arshad, S. H., Holloway, J. W., Håberg, S. E., Magnus, P., Dwyer, T., Binder, E. B., Demeo, D. L., Vonk, J. M., Newnham, J., Tantisira, K. G., Kull, I., Wiemels, J. L., Heude, B., Sunyer, J., Nystad, W., Munthe-Kaas, M. C., Raïkkönen, K., Oken, E., Huang, R. C., Weiss, S. T., Antó, J. M., Bousquet, J., Kumar, A., Söderhäll, C., Almqvist, C., Cardenas, A., Gruzieva, O., Xu, C. J., Reese, S. E., Kere, J., Brodin, P., Solomon, O., Wielscher, M., Holland, N., Ghantous, A., Hivert, M. F., Felix, J. F., Koppelman, G. H., London, S. J. & Melén, E., 2 Mar 2020, In: Genome Medicine. 12, 1, 25.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    24 Citations (Scopus)

Cite this