Effects of digested onion extracts on intestinal gene expression using rat intestine slices

  • P.J.M. Hendriksen (Creator)

Dataset

Description

Rat small intestine precision cut slices were exposed for 6 hours to in vitro digested yellow (YOd) or white onion extracts (WOd) that was followed by transcriptomics analysis. The digestion was performed to mimic the digestion that in vivo takes place in the saliva, stomach and small intestine. A main question was to which extent the outcome of the biological interpretation of the transcription analysis (pathway analysis) depend on the model used. One outcome was that mainly processes related to oxidative stress, and especially the Keap1-Nrf2 pathway, were affected by onions in all three models.
Date made available29 Sep 2016
PublisherWageningen University & Research

Research Output

Effects of digested onion extracts on intestinal gene expression: an interspecies comparison using different intestine models

de Wit, N. J. W., Hulst, M. M., Govers, C. C. F. M., van der Meulen, J., van Hoef, A. M. A., Stoopen, G. M., Hamers, A. R. M., Hoekman, A. J. W., de Vos, C. H., Bovee, T. F. H., Smits, M. A., Mes, J. J. & Hendriksen, P. J. M., 15 Sep 2016, In : PLoS ONE. 11, 9, 18 p., e0160719.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 4 Citations (Scopus)

    Datasets

    Effects of digested onion extracts on intestinal gene expression using rat intestine slices

    de Wit, N. (Creator), Hulst, M. (Creator), Govers, C. (Creator), van der Meulen, J. (Creator), van Hoef, A. M. A. (Creator), Stoopen, G. (Creator), Hamers, A. (Creator), Hoekman, A. J. W. (Creator), de Vos, R. (Creator), Bovee, T. (Creator), Smits, M. A. (Creator), Mes, J. (Creator) & Hendriksen, P. J. M. (Creator), Wageningen University & Research, 10 Jul 2016

    Dataset

    Cite this

    Hendriksen, P. J. M. (Creator) (29 Sep 2016). Effects of digested onion extracts on intestinal gene expression using rat intestine slices. Wageningen University & Research.