Detailed localisation of diet-induced changes in gene expression in the murine small intestine.

Dataset

Description

An increasing amount of evidence suggests that the small intestine may play an important role in the development of metabolic diseases, such as obesity and insulin resistance. The small intestine provides the first barrier between diet and the body. As a result, dysregulation of biological processes and secretion of signal molecules from the small intestine may be of importance in the regulation and dysregulation of whole body metabolic homeostasis. Changes in gene expression of genes involved in lipid metabolism, cell cycle and immune response may contribute to the aetiology of diet-induced obesity and insulin resistance. In the current study we present a detailed investigation on the effects a chow diet, low fat diet and high fat diet on gene expression along the proximal-to-distal axis of the murine small intestine. The reported results provide a knowledge base for upcoming studies on the role of the small intestine in the aetiology of diet-induced diseases.
Date made available9 Feb 2017
PublisherWageningen University

Research Output

Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine

van der Wielen, N., van Avesaat, M., de Wit, N. J. W., Vogels, J., Troost, F., Masclee, A., Koopmans, S. J., van der Meulen, J., Boekschoten, M. V., Müller, M. R., Hendriks, H. F. J., Witkamp, R. F. & Meijerink, J., 2014, In : PLoS ONE. 9, 9, 9 p., e107531.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 25 Citations (Scopus)

    Cite this

    de Wit, N. (Creator), Boekschoten, M. (Creator), Hooiveld, G. (Creator), Muller, M. (Creator) (9 Feb 2017). Detailed localisation of diet-induced changes in gene expression in the murine small intestine. Wageningen University.