Dataset underlying publication: De novo DNA-based catch bonds



All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.
Date made available10 Jul 2023
PublisherWageningen University & Research
Temporal coverage2019 - 2023
Geospatial point51.984, 5.6615Show on map


  • catch bonds
  • DNA nanotechnology
  • Mechanochemistry
  • rolling adhesion
  • supramolecular adhesion

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