Data from: Tipping elements in the human intestinal ecosystem



The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify groups of bacteria that exhibit robust bistable abundance distributions. These bacteria are either abundant or nearly absent in most individuals, and exhibit decreased temporal stability at the intermediate abundance range. The abundances of these bimodally distributed bacteria vary independently, and their abundance distributions are not affected by short-term dietary interventions. However, their contrasting alternative states are associated with host factors such as ageing and overweight. We propose that the bistable groups reflect tipping elements of the intestinal microbiota, whose critical transitions may have profound health implications and diagnostic potential.,HITChip phylogenetic microarray data matrixProfiling of 130 genus-like taxa across 1006 western subjects based on the Human Intestinal Tract (HIT)Chip phylogenetic microarray.HITChip.tabMetadataMetadata for the 1172 samples in the HITChip data matrix including age, sex, geographic region, DNA extraction information, projectID, probe-level Shannon diversity, BMI group,subjectID and time point. For units and other details, see the README file.,
Date made available19 May 2015
PublisherWageningen University & Research

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