Colonic gene expression upon dietary treatment

  • G.C.H. Rodenburg (Creator)
  • Evelien Kramer (Creator)
  • I. Bovee-Oudenhoven (Creator)
  • Jaap Keijer (Creator)



To increase our knowledge of the effects of Fructo oligosaccharides (FOS) on the intestinal barrier function in rats, a controlled rat infection study was performed. Two groups of rats were adapted to a diet with or without FOS. mRNA was collected from the mucosa of the colon and changes in gene expression were assessed using an agilent rat whole genome microarray (G4131A Agilent Technologies). Results indicate that dietary FOS influences energy metabolism, which will most likely play a role in the effects of FOS on the intestinal barrier.
Date made available1 Dec 2007
PublisherRikilt - Institute of Food Safety

Research Output

A framework to identify physiological responses in microarray based gene expression studies: selection and interpretation of biologically relevant genes

Rodenburg, G. C. H., Heidema, A. G., Boer, J. M. A., Bovee-Oudenhoven, I. M. J., Feskens, E. J. M., Mariman, E. C. M. & Keijer, J., 2008, In : Physiological genomics. 33, p. 78-90

Research output: Contribution to journalArticleAcademicpeer-review

  • 35 Citations (Scopus)

    Cite this

    Rodenburg, G. C. H. (Creator), Kramer, E. (Creator), Bovee-Oudenhoven, I. (Creator), Keijer, J. (Creator) (1 Dec 2007). Colonic gene expression upon dietary treatment. Rikilt - Institute of Food Safety.