Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

  • Silvie Timmers (Creator)
  • Ellen Konings (Creator)
  • Lena Bilet (Creator)
  • Riekelt H. Houtkooper (Creator)
  • Tineke van de Weijer (Creator)
  • Joris Hoeks (Creator)
  • Sophie van der Krieken (Creator)
  • Dongryeol Ryu (Creator)
  • Sander Kersten (Creator)
  • Esther Moonen-Kornips (Creator)
  • Gijs H. Goossens (Creator)
  • Matthijs K. Hesselink (Creator)
  • Iris Kunz (Creator)
  • Vera B. Schrauwen-Hinderling (Creator)
  • Ellen E. Blaak (Creator)
  • Johan Auwerx (Creator)
  • Patrick Schrauwen (Creator)

Dataset

Description

Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross-over study for 30 days. Resveratrol supplementation significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces profound metabolic changes in obese subjects, mimicking the effects of calorie restriction.
Date made available8 Nov 2011
PublisherWageningen University

Research Output

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, A. H., Moonen-Kornips, E., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V. B., Blaak, E. E., Auwerx, J. & Schrauwen, P., 2011, In : Cell Metabolism. 14, 5, p. 612-622

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 756 Citations (Scopus)

    Cite this

    Timmers, S. (Creator), Konings, E. (Creator), Bilet, L. (Creator), Houtkooper, R. H. (Creator), van de Weijer, T. (Creator), Hoeks, J. (Creator), van der Krieken, S. (Creator), Ryu, D. (Creator), Kersten, S. (Creator), Moonen-Kornips, E. (Creator), Goossens, G. H. (Creator), Hesselink, M. K. (Creator), Kunz, I. (Creator), Schrauwen-Hinderling, V. B. (Creator), Blaak, E. E. (Creator), Auwerx, J. (Creator), Schrauwen, P. (Creator) (8 Nov 2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Wageningen University.