Assessment of Dietary Modulation of Inflammatory Tone (ADMIT)



The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6, 8 and 10 h after consumption of the treatment products. Inflammation (IFN(gamma), IL-1(beta), IL-6, IL-8, IL-10, IL-12p70, TNF-(alpha), CRP, ICAM-1, VCAM-1, SAA, E-selectin, P-selectin, thrombomodulin, leukocytes, neutrophils, lymphocytes) and clinical (e.g. glucose, insulin, triglycerides) markers as well as gene expression in blood cells and plasma oxylipin profiles were measured.
Date made available13 Dec 2012
PublisherWageningen UR

Research Output

Strategies for individual phenotyping of linoleic and arachidonic Acid metabolism using an oral glucose tolerance test

Saccenti, E., van Duynhoven, J. P. M., Jacobs, D. M., Smilde, A. K. & Hoefsloot, H. C., 2015, In : PLoS ONE. 10, 3, 16 p., e0119856.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 6 Citations (Scopus)

    Cite this

    Saccenti, E. (Creator), Ernst, R. (Creator), Coolen, J. (Creator) (13 Dec 2012). Assessment of Dietary Modulation of Inflammatory Tone (ADMIT). Wageningen UR.