Research Output per year
The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6, 8 and 10 h after consumption of the treatment products. Inflammation (IFN(gamma), IL-1(beta), IL-6, IL-8, IL-10, IL-12p70, TNF-(alpha), CRP, ICAM-1, VCAM-1, SAA, E-selectin, P-selectin, thrombomodulin, leukocytes, neutrophils, lymphocytes) and clinical (e.g. glucose, insulin, triglycerides) markers as well as gene expression in blood cells and plasma oxylipin profiles were measured.
|Date made available||13 Dec 2012|
Strategies for individual phenotyping of linoleic and arachidonic Acid metabolism using an oral glucose tolerance testSaccenti, E., van Duynhoven, J. P. M., Jacobs, D. M., Smilde, A. K. & Hoefsloot, H. C., 2015, In : PLoS ONE. 10, 3, 16 p., e0119856.
Research output: Contribution to journal › Article › Academic › peer-review
Saccenti, E. (Creator), Ernst, R. (Creator), Coolen, J. (Creator) (13 Dec 2012). Assessment of Dietary Modulation of Inflammatory Tone (ADMIT). Wageningen UR.