Research Output per year
Transcriptome analysis comparing the gene expression of A. muciniphila grown on mucin or glucose media confirmed the activity of the genes involved in mucin degradation, and revealed most of them to be upregulated in the presence of mucin. A. muciniphila grown on glucose showed a stress response and upregulation of specific genes, such as Amuc_1094 which was identified as a glucokinase induced by glucose. The transcriptional response was confirmed by a proteome analysis, reinforcing the adaptation of A. muciniphila to the mucosal environment. These new findings provide molecular insights into the lifestyle of A. muciniphila, and further confirm its role as a mucin specialist in the gut.
|Date made available||9 May 2017|
Genome-scale model and omics analysis of metabolic capacities of Akkermansia muciniphila reveal a preferential mucin-degrading lifestyleOttman, N., Davids, M., Suarez-Diez, M., Boeren, S., Schaap, P. J., Martins dos Santos, V., Smidt, H., Belzer, C. & de Vos, W. M., 2017, In : Applied and Environmental Microbiology. 83, 18, e01014.
Research output: Contribution to journal › Article › Academic › peer-review
Ottman, N. A. (Creator), Davids, M. (Creator), Suarez Diez, M. (Creator), Boeren, J. A. (Creator), Schaap, P. J. (Creator), Martins dos Santos, V. A. P. (Creator), Smidt, H. (Creator), Belzer, C. (Creator), de Vos, W. M. (Creator) (9 May 2017). Akkermansia transcriptome response to mucin and/or glucose growth medium. Wageningen University.