Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

  • Rebecca Rogier (Creator)
  • Thomas H.A. Ederveen (Creator)
  • Jos Boekhorst (Creator)
  • H.J. Wopereis (Creator)
  • Jose U. Scher (Creator)
  • Julia Manasson (Creator)
  • Jan Knol (Creator)
  • Johan Garssen (Creator)
  • Peter M. van der Kraan (Creator)
  • Marije I. Koenders (Creator)
  • Wim B. van den Berg (Creator)
  • Sacha A.F.T. van Hijum (Creator)
  • Shahla Abdollahi-Roodsaz (Creator)

Dataset

Description

The aim of this study was to investigate the role of IL-1 receptor signalling and the involvement of Toll-like receptor (TLR) 2 and TLR4 in defining the intestinal microbiota and the associated mucosal and systemic immune response. Multiplex 454 pyrosequencing of V5 and V6 hyper-variable regions of fecal bacterial 16S rRNA was used to define intestinal microbial communities in BALB/c wild type (WT), IL-1Ra-/- and IL-1Ra/TLR double knock-out (DKO) mice.
Date made available3 Oct 2014
PublisherRadboud University

Research Output

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

Rogier, R., Ederveen, T. H. A., Boekhorst, J., Wopereis, H., Scher, J. U., Manasson, J., Frambach, S. J. C. M., Knol, J., Garssen, J., van der Kraan, P. M., Koenders, M. I., van den Berg, W. B., van Hijum, S. A. F. T. & Abdollahi-Roodsaz, S., 23 Jun 2017, In : Microbiome. 5, 1, p. 63

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 23 Citations (Scopus)

    Cite this

    Rogier, R. (Creator), Ederveen, T. H. A. (Creator), Boekhorst, J. (Creator), Wopereis, H. J. (Creator), Scher, J. U. (Creator), Manasson, J. (Creator), Knol, J. (Creator), Garssen, J. (Creator), van der Kraan, P. M. (Creator), Koenders, M. I. (Creator), van den Berg, W. B. (Creator), van Hijum, S. A. F. T. (Creator), Abdollahi-Roodsaz, S. (Creator) (3 Oct 2014). Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis. Radboud University.