Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

  • Rebecca Rogier (Creator)
  • Thomas H.A. Ederveen (Creator)
  • Jos Boekhorst (Creator)
  • H.J. Wopereis (Creator)
  • Jose U. Scher (Creator)
  • Julia Manasson (Creator)
  • Jan Knol (Creator)
  • Johan Garssen (Creator)
  • Peter M. van der Kraan (Creator)
  • Marije I. Koenders (Creator)
  • Wim B. van den Berg (Creator)
  • Sacha A.F.T. van Hijum (Creator)
  • Shahla Abdollahi-Roodsaz (Creator)



The aim of this study was to investigate the role of IL-1 receptor signalling and the involvement of Toll-like receptor (TLR) 2 and TLR4 in defining the intestinal microbiota and the associated mucosal and systemic immune response. Multiplex 454 pyrosequencing of V5 and V6 hyper-variable regions of fecal bacterial 16S rRNA was used to define intestinal microbial communities in BALB/c wild type (WT), IL-1Ra-/- and IL-1Ra/TLR double knock-out (DKO) mice.
Date made available3 Oct 2014
PublisherRadboud University

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